DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HIPK1 and hipk1

DIOPT Version :9

Sequence 1:	NP_001356735.1	Gene:	HIPK1 / 204851	HGNCID:	19006	Length:	1210	Species:	Homo sapiens
Sequence 2:	XP_012819927.1	Gene:	hipk1 / 734033	XenbaseID:	XB-GENE-987412	Length:	1218	Species:	Xenopus tropicalis

Alignment Length:	1224	Identity:	1031/1224 - (84%)
Similarity:	1105/1224 - (90%)	Gaps:	20/1224 - (1%)

- Green bases have known domain annotations that are detailed below.

Human     1 MASQLQVFSPPSVSSSAFCSAKKLKIEPSGWDVSGQSSNDKYYTHSKTLPATQGQANSSHQVANF 65
            ||||||||||.||||||||||||||:|||||||:||.|::|||||:|.||..||.|:||||||.|
Frog     1 MASQLQVFSPSSVSSSAFCSAKKLKVEPSGWDVTGQGSSNKYYTHTKNLPVAQGHASSSHQVAGF 65

Human    66 NIPAYDQGLLLPAPAVEHIVVTAADSSGSAATSTFQSSQTLTHRSNVSLLEPYQKCGLKRKSEEV 130
            ::|||:..||:||.|.||||||||||:.|..|::||:||.|||||||.||:||||||||||||||
Frog    66 SLPAYEPNLLIPAAAAEHIVVTAADSTDSGPTTSFQNSQILTHRSNVPLLDPYQKCGLKRKSEEV 130

Human   131 DSNGSVQIIEEHPPLMLQNRTVVGAAATTTTVTTKSSSSSGEGDYQLVQHEILCSMTNSYEVLEF 195
            |||||||||:|.|||||||||||||||||||||||||||:|||||||||||||||||||||||||
Frog   131 DSNGSVQIIDERPPLMLQNRTVVGAAATTTTVTTKSSSSNGEGDYQLVQHEILCSMTNSYEVLEF 195

Human   196 LGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSRLSSENADEYNFVRSYECFQH 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Frog   196 LGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSRLSSENADEYNFVRSYECFQH 260

Human   261 KNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATALMKLKSLGLIHADLKPENIMLVD 325
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Frog   261 KNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATALMKLKSLGLIHADLKPENIMLVD 325

Human   326 PVRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWP 390
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Frog   326 PVRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWP 390

Human   391 LYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKE 455
            ||||||||||||||||||||||||||||||||:|||||||:|||||||||.|:|||:||||||||
Frog   391 LYPGASEYDQIRYISQTQGLPAEYLLSAGTKTSRFFNRDPDLGYPLWRLKAPDEHEMETGIKSKE 455

Human   456 ARKYIFNCLDDMAQVNMSTDLEGTDMLAEKADRREYIDLLKKMLTIDADKRITPLKTLNHQFVTM 520
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.||||
Frog   456 ARKYIFNCLDDMAQVNMSTDLEGTDMLAEKADRREYIDLLKKMLTIDADKRITPLKTLNHPFVTM 520

Human   521 THLLDFPHSNHVKSCFQNMEICKRRVHMYDTVSQIKSPFTTHVAPNTSTNLTMSFSNQLNTVHNQ 585
            |||||||||||||||||||||||||.:|||||:||||||||||||||||||||||:||||:||||
Frog   521 THLLDFPHSNHVKSCFQNMEICKRRSNMYDTVNQIKSPFTTHVAPNTSTNLTMSFNNQLNSVHNQ 585

Human   586 ASVLASSSTAAAATLSLANSDVSLLNYQSALYPSSAAPVPGVAQQGVSLQPGTTQICTQTDPFQQ 650
            ||||||||| |||||||||||||||||||||||.:|.||.||.||.|||||||||:|||||||||
Frog   586 ASVLASSST-AAATLSLANSDVSLLNYQSALYPPAAGPVTGVTQQSVSLQPGTTQLCTQTDPFQQ 649

Human   651 TFIVCPPAFQ-TGLQATTKHSGFPVRMDNAVPIVPQAPAAQPLQIQSGVLTQGSCTPLMVATLHP 714
            |||||||||| .|||||||||||||||||:|||||||||||||||||||||||||||||||||||
Frog   650 TFIVCPPAFQAAGLQATTKHSGFPVRMDNSVPIVPQAPAAQPLQIQSGVLTQGSCTPLMVATLHP 714

Human   715 QVATITPQYAVPFTLSCAAGRPALVEQTAAVLQAWPGGTQQILLPSTWQQLPGVALHNSVQPTAM 779
            .||||||||||||||:|||||||||||||||||||||||||||||||||||||||||||||||||
Frog   715 HVATITPQYAVPFTLNCAAGRPALVEQTAAVLQAWPGGTQQILLPSTWQQLPGVALHNSVQPTAM 779

Human   780 IPEAMGSGQQLADWRNAHSHGNQYSTIMQQPSLLTNHVTLATAQPLNVGVAHVVRQQQSSSLPSK 844
            |||.:|:.|||.||||||||||||||:|||||||.||||||.||||||||||||||||:|:..:|
Frog   780 IPETIGNNQQLTDWRNAHSHGNQYSTLMQQPSLLANHVTLAAAQPLNVGVAHVVRQQQNSNTSTK 844

Human   845 KNKQSAPVSSK---SSLDVLPSQVYSLVGSSPLRTTSSYNSLVPVQDQHQPIIIPDTPSPPVSVI 906
            ||||.|..||.   |||||:|||||||||||||:.:||||.|:|:|:|.|||:||||||||||||
Frog   845 KNKQQASQSSSKALSSLDVIPSQVYSLVGSSPLQASSSYNPLLPLQEQRQPIVIPDTPSPPVSVI 909

Human   907 TIRSDTDEEEDNKYKPSSSGLKPRSNVISYVTVNDSPDSDSSLSSPYSTDTLSALRGNSGSVLEG 971
            |||||||||||:||||::||:|.|||||||||||||||||||:||||..|..:::.|.:|.....
Frog   910 TIRSDTDEEEDSKYKPTNSGMKLRSNVISYVTVNDSPDSDSSVSSPYLADRHTSVNGVTGVFDMS 974

Human   972 PGRVV-ADGTGTRTIIVPPLKTQLGDCTVATQASGLLSNK---TKPVASVSGQSSGCCITPTGYR 1032
            ..|.. :....:|||||||||:|:.||.:.||.:|:||..   ||...:.:||||. |||.||.|
Frog   975 NSRTAHSQSLNSRTIIVPPLKSQMNDCPLDTQLTGVLSGAAKITKSCTATNGQSSS-CITQTGCR 1038

Human  1033 AQRGGTSAAQPLNLSQNQQSSAAPTSQERSSNPAPRRQQAFVAPL---SQAPYTFQHGSPLHSTG 1094
            :.| ..:..|||||||||||:...| ||||.||..|||||:||||   ||||:||||.||||||.
Frog  1039 SHR-MLNGVQPLNLSQNQQSAMMGT-QERSMNPGSRRQQAYVAPLPSISQAPFTFQHSSPLHSTV 1101

Human  1095 HPHL---APAPAHLPSQAHLYTYAAPTSAAALGSTSSIAHLFSPQGSSRHAAAYTTHPSTLVHQV 1156
            ||||   |.|.:||.||.|:||| |||:||:||||:|||||||||||||| ..:.||||||||||
Frog  1102 HPHLAAAATATSHLTSQPHMYTY-APTTAASLGSTTSIAHLFSPQGSSRH-TTFATHPSTLVHQV 1164

Human  1157 PVSVGPSLLTSASVAPAQYQHQFATQSYIGSSRGSTIYTGYPLSPTKISQYSYL 1210
            ||||||||||||:||.|||.||||.|||||:||||.||||||||||.|:|||||
Frog  1165 PVSVGPSLLTSANVASAQYPHQFAAQSYIGASRGSAIYTGYPLSPTNINQYSYL 1218

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HIPK1	NP_001356735.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1084..1103		15/21 (71%)
		STKc_HIPK1	174..528	CDD:271130	347/353 (98%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	835..856		12/23 (52%)
		Nuclear localization signal 1 (NLS1). /evidence=ECO:0000250	844..847		2/2 (100%)
		Interaction with TP53. /evidence=ECO:0000269\|PubMed:12702766	885..1093		132/214 (62%)
		Required for localization to nuclear speckles. /evidence=ECO:0000250	891..998		71/107 (66%)
		SUMO interaction motifs (SIM), required for nuclear localization and kinase activity. /evidence=ECO:0000250	902..926		20/23 (87%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	909..974		42/64 (66%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1046..1069		14/22 (64%)
hipk1	XP_012819927.1	STKc_HIPK1	174..528	CDD:271130	347/353 (98%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	1042	1.000	Domainoid score	I582
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56483
Inparanoid	1	1.050	2006	1.000	Inparanoid score	I672
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG37617
OrthoDB	1	1.010	-	-		D28823at32523
OrthoFinder	1	1.000	-	-		FOG0002956
OrthoInspector	1	1.000	-	-		oto157413
Panther	1	1.100	-	-	LDO	PTHR24058
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R968
SonicParanoid	1	1.000	-	-		X805
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	13.110