DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment HIPK1 and Dyrk2

DIOPT Version :10

Sequence 1:NP_938009.1 Gene:HIPK1 / 204851 HGNCID:19006 Length:1210 Species:Homo sapiens
Sequence 2:NP_001260456.1 Gene:Dyrk2 / 34831 FlyBaseID:FBgn0016930 Length:757 Species:Drosophila melanogaster


Alignment Length:512 Identity:153/512 - (29%)
Similarity:256/512 - (50%) Gaps:60/512 - (11%)


- Green bases have known domain annotations that are detailed below.


Human    87 TAADSSGSAATSTFQSS-QTLTHRSNVSLLEPYQKCGLKRKSEEVDSNGSVQIIEEHPPLMLQNR 150
            :.:.|||::|:||.... :..|..:...|::.::......:.||:.....|....:|..   :|.
  Fly   139 SGSGSSGNSASSTGSGELKCNTPMTPSELVKKFRNYLTDLEFEELKVYKEVWYFGQHAS---KNY 200

Human   151 TVVGAAATTTTVTTKSSSSSGEGDYQLVQHEILCSMTNSYEVLEFLGRGTFGQVAKCWKRSTKEI 215
            ......|.||.:    ......|:|::::|:   .:...||:||.:|:|:||||.:.....|...
  Fly   201 NKPAPTANTTNL----GYDDDNGNYKIIEHD---HIAFRYEILEVIGKGSFGQVIRALDHKTNTH 258

Human   216 VAIKILKNHPSYARQGQIEVSILSRLSSENAD-EYNFVRSYECFQHKNHTCLVFEMLEQNLYDFL 279
            |||||::|...:..|..:|::||..|..::|| .:|.:...:....:.|.|:.||::..|||:.:
  Fly   259 VAIKIIRNKKRFLNQAVVELNILDELREKDADGSHNVIHMLDYTYFRKHLCITFELMSLNLYELI 323

Human   280 KQNKFSPLPLKYIRPILQQVATALMKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHV 344
            |:|.::...:..||.....:...|..|....:||.|||||||:|..  |....:|||||||:.:|
  Fly   324 KKNNYNGFSMSLIRRFCNSIVKCLRLLYKENIIHCDLKPENILLKQ--RGSSSIKVIDFGSSCYV 386

Human   345 SKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQG 409
            .:.: .||:|||:||:||:||||.:..|||||||||::|||:.|:||:||.:|.:|:..|.:..|
  Fly   387 DRKI-YTYIQSRFYRSPEVILGLQYGTAIDMWSLGCILAELYTGFPLFPGENEVEQLACIMEVLG 450

Human   410 LPAEYLLSAGTKTTRFF-NRD-PNLGYPLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNM 472
            ||.:.|:|...:...|| :|| |..      :...:..:...|.||   ..:|.:|.|       
  Fly   451 LPPKVLISVARRRRLFFDSRDAPRC------ITNTKGRKRSPGSKS---LAHILHCQD------- 499

Human   473 STDLEGTDMLAEKADRREYIDLLKKMLTIDADKRITPLKTLNHQFVTMTHLLDFPHSNHVKSCFQ 537
                            |.:||.|::.|..|..:|:||.:..:|:|     |.....|.| :||..
  Fly   500 ----------------RYFIDFLQRCLEWDPAERMTPDEAAHHEF-----LQPSASSRH-RSCRM 542

Human   538 NMEICKRRVHMYDTVSQIKSPFT-THVAPNTSTNLTMSFSNQLNTVHNQASVLASSS 593
            :.......:   ::|||..|.:: :.::|.|:..:..|.:: ...|||.|....:.|
  Fly   543 SSSSSSSGL---NSVSQKSSCYSFSEISPGTNGPVVASITS-TTAVHNAAIATTTKS 595

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HIPK1NP_938009.1 STKc_HIPK1 174..528 CDD:271130 120/356 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 835..856
Nuclear localization signal 1 (NLS1). /evidence=ECO:0000250 844..847
Interaction with TP53. /evidence=ECO:0000269|PubMed:12702766 885..1093
Required for localization to nuclear speckles. /evidence=ECO:0000250 891..998
SUMO interaction motifs (SIM), required for nuclear localization and kinase activity. /evidence=ECO:0000250 902..926
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 909..974
Atrophin-1 1028..>1183 CDD:460830
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1046..1069
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1084..1103
Dyrk2NP_001260456.1 PKc_DYRK4 186..529 CDD:271127 126/392 (32%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.