DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HIPK1 and Hipk1

DIOPT Version :9

Sequence 1:	NP_001356735.1	Gene:	HIPK1 / 204851	HGNCID:	19006	Length:	1210	Species:	Homo sapiens
Sequence 2:	NP_001288233.1	Gene:	Hipk1 / 15257	MGIID:	1314873	Length:	1210	Species:	Mus musculus

Alignment Length:	1210	Identity:	1182/1210 - (97%)
Similarity:	1196/1210 - (98%)	Gaps:	0/1210 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MASQLQVFSPPSVSSSAFCSAKKLKIEPSGWDVSGQSSNDKYYTHSKTLPATQGQANSSHQVANF 65
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||:||||||||
Mouse     1 MASQLQVFSPPSVSSSAFCSAKKLKIEPSGWDVSGQSSNDKYYTHSKTLPATQGQASSSHQVANF 65

Human    66 NIPAYDQGLLLPAPAVEHIVVTAADSSGSAATSTFQSSQTLTHRSNVSLLEPYQKCGLKRKSEEV 130
            |:||||||||||||||||||||||||||||||:||||||||||||||||||||||||||||||||
Mouse    66 NLPAYDQGLLLPAPAVEHIVVTAADSSGSAATATFQSSQTLTHRSNVSLLEPYQKCGLKRKSEEV 130

Human   131 DSNGSVQIIEEHPPLMLQNRTVVGAAATTTTVTTKSSSSSGEGDYQLVQHEILCSMTNSYEVLEF 195
            :||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   131 ESNGSVQIIEEHPPLMLQNRTVVGAAATTTTVTTKSSSSSGEGDYQLVQHEILCSMTNSYEVLEF 195

Human   196 LGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSRLSSENADEYNFVRSYECFQH 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   196 LGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSRLSSENADEYNFVRSYECFQH 260

Human   261 KNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATALMKLKSLGLIHADLKPENIMLVD 325
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   261 KNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATALMKLKSLGLIHADLKPENIMLVD 325

Human   326 PVRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWP 390
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   326 PVRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWP 390

Human   391 LYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKE 455
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   391 LYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKE 455

Human   456 ARKYIFNCLDDMAQVNMSTDLEGTDMLAEKADRREYIDLLKKMLTIDADKRITPLKTLNHQFVTM 520
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   456 ARKYIFNCLDDMAQVNMSTDLEGTDMLAEKADRREYIDLLKKMLTIDADKRITPLKTLNHQFVTM 520

Human   521 THLLDFPHSNHVKSCFQNMEICKRRVHMYDTVSQIKSPFTTHVAPNTSTNLTMSFSNQLNTVHNQ 585
            :||||||||:|||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   521 SHLLDFPHSSHVKSCFQNMEICKRRVHMYDTVSQIKSPFTTHVAPNTSTNLTMSFSNQLNTVHNQ 585

Human   586 ASVLASSSTAAAATLSLANSDVSLLNYQSALYPSSAAPVPGVAQQGVSLQPGTTQICTQTDPFQQ 650
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   586 ASVLASSSTAAAATLSLANSDVSLLNYQSALYPSSAAPVPGVAQQGVSLQPGTTQICTQTDPFQQ 650

Human   651 TFIVCPPAFQTGLQATTKHSGFPVRMDNAVPIVPQAPAAQPLQIQSGVLTQGSCTPLMVATLHPQ 715
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   651 TFIVCPPAFQTGLQATTKHSGFPVRMDNAVPIVPQAPAAQPLQIQSGVLTQGSCTPLMVATLHPQ 715

Human   716 VATITPQYAVPFTLSCAAGRPALVEQTAAVLQAWPGGTQQILLPSTWQQLPGVALHNSVQPTAMI 780
            |||||||||||||||||||||||||||||||||||||||||||||.|||||||||||||||.|:|
Mouse   716 VATITPQYAVPFTLSCAAGRPALVEQTAAVLQAWPGGTQQILLPSAWQQLPGVALHNSVQPAAVI 780

Human   781 PEAMGSGQQLADWRNAHSHGNQYSTIMQQPSLLTNHVTLATAQPLNVGVAHVVRQQQSSSLPSKK 845
            ||||||.||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   781 PEAMGSSQQLADWRNAHSHGNQYSTIMQQPSLLTNHVTLATAQPLNVGVAHVVRQQQSSSLPSKK 845

Human   846 NKQSAPVSSKSSLDVLPSQVYSLVGSSPLRTTSSYNSLVPVQDQHQPIIIPDTPSPPVSVITIRS 910
            |||||||||||||:|||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   846 NKQSAPVSSKSSLEVLPSQVYSLVGSSPLRTTSSYNSLVPVQDQHQPIIIPDTPSPPVSVITIRS 910

Human   911 DTDEEEDNKYKPSSSGLKPRSNVISYVTVNDSPDSDSSLSSPYSTDTLSALRGNSGSVLEGPGRV 975
            ||||||||||||:||.||.|||||||||||||||||||||||:.||||||||||||::||||||.
Mouse   911 DTDEEEDNKYKPNSSSLKARSNVISYVTVNDSPDSDSSLSSPHPTDTLSALRGNSGTLLEGPGRP 975

Human   976 VADGTGTRTIIVPPLKTQLGDCTVATQASGLLSNKTKPVASVSGQSSGCCITPTGYRAQRGGTSA 1040
            .|||.||||||||||||||||||||||||||||:||||||||||||||||||||||||||||.||
Mouse   976 AADGIGTRTIIVPPLKTQLGDCTVATQASGLLSSKTKPVASVSGQSSGCCITPTGYRAQRGGASA 1040

Human  1041 AQPLNLSQNQQSSAAPTSQERSSNPAPRRQQAFVAPLSQAPYTFQHGSPLHSTGHPHLAPAPAHL 1105
            .||||||||||||:|.||||||||||||||||||||||||||.||||||||||||||||||||||
Mouse  1041 VQPLNLSQNQQSSSASTSQERSSNPAPRRQQAFVAPLSQAPYAFQHGSPLHSTGHPHLAPAPAHL 1105

Human  1106 PSQAHLYTYAAPTSAAALGSTSSIAHLFSPQGSSRHAAAYTTHPSTLVHQVPVSVGPSLLTSASV 1170
            |||.|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse  1106 PSQPHLYTYAAPTSAAALGSTSSIAHLFSPQGSSRHAAAYTTHPSTLVHQVPVSVGPSLLTSASV 1170

Human  1171 APAQYQHQFATQSYIGSSRGSTIYTGYPLSPTKISQYSYL 1210
            ||||||||||||||||||||||||||||||||||||||||
Mouse  1171 APAQYQHQFATQSYIGSSRGSTIYTGYPLSPTKISQYSYL 1210

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HIPK1	NP_001356735.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1084..1103		18/18 (100%)
		STKc_HIPK1	174..528	CDD:271130	352/353 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	835..856		20/20 (100%)
		Nuclear localization signal 1 (NLS1). /evidence=ECO:0000250	844..847		2/2 (100%)
		Interaction with TP53. /evidence=ECO:0000269\|PubMed:12702766	885..1093		191/207 (92%)
		Required for localization to nuclear speckles. /evidence=ECO:0000250	891..998		96/106 (91%)
		SUMO interaction motifs (SIM), required for nuclear localization and kinase activity. /evidence=ECO:0000250	902..926		22/23 (96%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	909..974		57/64 (89%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1046..1069		20/22 (91%)
Hipk1	NP_001288233.1	STKc_HIPK1	174..528	CDD:271130	352/353 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	835..856		20/20 (100%)
		Nuclear localization signal 1 (NLS1). /evidence=ECO:0000250	844..847		2/2 (100%)
		Interaction with TP53. /evidence=ECO:0000269\|PubMed:12702766	885..1093		191/207 (92%)
		Required for localization to nuclear speckles. /evidence=ECO:0000250	891..998		96/106 (91%)
		SUMO interaction motifs (SIM), required for nuclear localization and kinase activity. /evidence=ECO:0000250	902..926		22/23 (96%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	938..981		36/42 (86%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1046..1069		20/22 (91%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1084..1104		19/19 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83974151
Domainoid	1	1.000	1330	1.000	Domainoid score	I865
eggNOG	1	0.900	-	-		E1_KOG0667
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56483
Inparanoid	1	1.050	2355	1.000	Inparanoid score	I1055
Isobase	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG37617
OrthoDB	1	1.010	-	-		D38932at33208
OrthoFinder	1	1.000	-	-		FOG0002956
OrthoInspector	1	1.000	-	-		oto125155
orthoMCL	1	0.900	-	-		OOG6_103159
Panther	1	1.100	-	-	LDO	PTHR24058
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R968
SonicParanoid	1	1.000	-	-		X805
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	18	18.340