DRSC/TRiP Functional Genomics Resources

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Protein Alignment EPHB2 and dnt

DIOPT Version :10

Sequence 1:NP_001296122.1 Gene:EPHB2 / 2048 HGNCID:3393 Length:1055 Species:Homo sapiens
Sequence 2:NP_477341.2 Gene:dnt / 35207 FlyBaseID:FBgn0024245 Length:584 Species:Drosophila melanogaster


Alignment Length:375 Identity:97/375 - (25%)
Similarity:177/375 - (47%) Gaps:42/375 - (11%)


- Green bases have known domain annotations that are detailed below.


Human   541 LPLIIGSSAA-GLVFLIAVVVIAI--VCNRR-------------GFERADSEYTDKLQHYTSGHM 589
            :.|::|.|.| |.|.|:.::...:  ..|:|             .|:|.::....:....::.:|
  Fly   210 ITLVVGVSVAMGSVCLLLMIAYCVKGAANKRQHHQHGGQPMRTSSFQRLNTHPPCQSSMGSAAYM 274

Human   590 TPGMKIYID--------PFTYED--PNEAVREFAKEIDISC-VKIEQVIGAGEFGEVCSGHLKLP 643
            ||.:...|.        |.:.|.  |.|..|..::.....| |::..::..|.||.|..|...  
  Fly   275 TPSIIAPIHGSSLPRKVPVSVEQQHPEELHRRISELTVERCRVRLSSLLQEGTFGRVYRGTYN-- 337

Human   644 GKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTK--STPVMIITEFMENGS 706
            ..:::.|  ||:....::.|....|.|..::....||.::.:.||..:  :||.::........:
  Fly   338 DTQDVLV--KTVAQHASQMQVLLLLQEGMLLYGASHPGILSVLGVSIEDHTTPFVLYPALNNTRN 400

Human   707 LDSFLRQNDGQFTV--IQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSR 769
            |..||.......||  ||:|.|...::..:.:|.....||:|:|.||.:::..|..|:||..|||
  Fly   401 LKQFLLDPACARTVTTIQIVMMASQLSMALDHLHSHGVVHKDIATRNCVIDDQLRVKLSDSSLSR 465

Human   770 FLEDDTSDPTYTSALGG--KIPIRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTN 832
            .|     .|:..:.||.  ..|::|.:.||:|:::|:.|||.|::|::|||:.:..::||.::..
  Fly   466 DL-----FPSDYNCLGDSENRPVKWMSLEALQHKQFSEASDSWAFGVLMWELCTSAKQPYAEVDP 525

Human   833 QDVINAIEQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTLDK 882
            .::.:.::..|||..|.:||..|..:|..||......||.|.|:.:.|.:
  Fly   526 FEMEHYLKDGYRLAQPFNCPDELFTIMAYCWALLPAERPTFAQLQSCLSE 575

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EPHB2NP_001296122.1 EphR_LBD_B2 19..196 CDD:198445
fn3 326..421 CDD:394996
fn3 437..520 CDD:394996
EphA2_TM 544..617 CDD:464211 19/98 (19%)
PTKc_EphR_B 616..884 CDD:173638 77/274 (28%)
SAM_EPH-B2 910..980 CDD:188951
PDZ-binding (in isoform 2). /evidence=ECO:0000255 984..986
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 990..1055
dntNP_477341.2 WIF 46..182 CDD:128745
Protein Kinases, catalytic domain 310..580 CDD:473864 77/275 (28%)
Blue background indicates that the domain is not in the aligned region.

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