Protein Alignment EPHB2 and CG3277

DIOPT Version :10

• Sequence 1: NP_001296122.1
• Gene: EPHB2 / 2048
• HGNCID: 3393
• Length: 1055
• Species: Homo sapiens
• Sequence 2: NP_608762.3
• Gene: CG3277 / 33543
• FlyBaseID: FBgn0031518
• Length: 789
• Species: Drosophila melanogaster
• Alignment Length: 732
• Identity: 160/732 - (21%)
• Similarity: 283/732 - (38%)
• Gaps: 196/732 - (26%)

Human   315 DPLDM-PCTTI---PSAPQAVISSVNETSLMLEWTPPRDSGGREDL----VYNIICKSCGSGR-- 369
            :|:.| |.|.:   |:....:.......:|.:|..|......:::|    .||::..:..:.|
  Fly    62 EPIAMEPLTRMRLNPNPDGEITELTTNVTLYMEKIPRLQVRWQDNLPQGTSYNVLVSAVNNSRCP 126

Human   370 -GACTRCG---DNVQYAPRQLGL-TEPRIYISDL----LAHTQYTFEIQAVNGVTDQS------- 418
             ..|:..|   .|.......:.| ..|.:.:..:    :...||...::..|.:..:|
  Fly   127 DAPCSEYGIKEKNASAETHSVNLPVNPNLNVESVDCNYMFGCQYQVIVETSNAMVRRSARVYIPQ 191

Human   419 -----------PFSPQFASV-NITTNQAAPSAVSI-------------MHQVSRTVDSITLSWSQ 458
                       |..|:..:| .:.:|:.....:||             :|:..||. .:.|..::
  Fly   192 CLEGKCSCQLAPTPPKVLAVAKMLSNETISINLSILASELLRKEQDSHLHETLRTY-KMQLKINE 255

Human   459 PDQPN----GVILDYELQYYEKELSEYNATAIKSPTNTVTVQGLKAGAIYVFQVRARTVAGYGRY 519
            ...|:    ||:.....:.|  :|||.|..|  :|.....|..|..|.    |::.:
  Fly   256 ETNPSLPWGGVLKHLMTRVY--KLSELNFRA--TPKGFEGVMKLGLGT----QLKEK-------- 304

Human   520 SGKMYFQTM----TEAEYQTSIQEKLP-------LIIGSSAAGLVFLIAVVVIAIVCN------- 566
             ..:..|.:    |..|...|: .|:|       |..|.|.:..:.:::.::|||:..
  Fly   305 -ASLSLQAVIIDPTGCEGPRSV-TKVPVPANPVLLTEGDSVSNSIIVMSAMLIAIILAGLIMLLL 367

Human   567 RRGFERADSEYTDKLQHYTSGHMTPGMKI-----YIDPFTYEDPNEAVREFAKEIDISCVKIEQV 626
            ||...|..::...:.|.|.....|..:::     |:|.:..:.....:.:.. |:..|.::|.::
  Fly   368 RRRRARTTAKLRKQEQIYIQTFATSAIEMEDNVNYVDKYVEKSQVLGLADIF-EVPHSAIQIGRM 431

Human   627 IGAGEFGEVCSGH----LKLPGKR-EIFVAIKTLKSGYTEKQRRDFLSEASIM-GQFDHPNVIHL 685
            :|.|.||:|   |    :.|...| ...||:|.||......:..::|:|..:: |...|.||:..
  Fly   432 LGEGAFGQV---HEATAINLRRMRGTTIVAVKQLKPNPKADEVAEYLAEIEMLKGVGTHHNVVSF 493

Human   686 EGVVTKSTPVMIITEFMENGSLDSFLR-------------------------------------- 712
            .|..|...|.::|.|::..|:|.|:||
  Fly   494 LGCCTIKPPYLMIMEYVNKGNLLSYLRTVRKEASKLRNRNANYTSCRPIMTRTNSTSSPKSQSVN 558

Human   713 --------------QNDG-----------------QFTVI-------------QLVGMLRGIAAG 733
                          |.|.                 .:|::             :|......||.|
  Fly   559 YIELKASSQTIEMPQEDSTAHMNGIRQPHPSFAETTYTIVEDEDAFEYILDNKELHNFALQIANG 623

Human   734 MKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAI 798
            |::|.:....||||||||:|::||...|:|||||||       ...||:....|:|:||.:.|||
  Fly   624 MRFLEEQEITHRDLAARNVLIDSNKTLKISDFGLSR-------HGIYTNTRTRKLPLRWLSIEAI 681

Human   799 QYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSALHQLMLDCW 863
            :...::|.||:|:||:|:||:.:.|..||..::|.::|..:....||..|..|...::.:||.||
  Fly   682 RENVYSSKSDIWAYGVVLWEIGTLGASPYPTISNDELIPFLMAGNRLERPEICTPQVYTIMLQCW 746

Human   864 QKDRNHRPKFGQIVNTL 880
            .::...||.|..:...|
  Fly   747 LEEPEERPTFDALYKVL 763

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EPHB2	NP_001296122.1	EphR_LBD_B2	19..196	CDD:198445
		fn3	326..421	CDD:394996	17/127 (13%)
		fn3	437..520	CDD:394996	20/99 (20%)
		EphA2_TM	544..617	CDD:464211	14/84 (17%)
		PTKc_EphR_B	616..884	CDD:173638	94/353 (27%)
		SAM_EPH-B2	910..980	CDD:188951
		PDZ-binding (in isoform 2). /evidence=ECO:0000255	984..986
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	990..1055
CG3277	NP_608762.3	PTKc	430..763	CDD:270623	91/342 (27%)