DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment EPHB1 and YPL150W

DIOPT Version :9

Sequence 1:	NP_004432.1	Gene:	EPHB1 / 2047	HGNCID:	3392	Length:	984	Species:	Homo sapiens
Sequence 2:	NP_015175.1	Gene:	YPL150W / 855953	SGDID:	S000006071	Length:	901	Species:	Saccharomyces cerevisiae

Alignment Length:	357	Identity:	93/357 - (26%)
Similarity:	154/357 - (43%)	Gaps:	66/357 - (18%)

- Green bases have known domain annotations that are detailed below.

Human   574 VYSDKLQHYSTGR--GSPGMKIYIDPFTYEDPNEAVREFAKEIDVSFVKIEEVIGAGEFGEVYKG 636
            |.|.||:..:...  ||...::| ..||.::..|          |...||.:.||.|.||:||..
Yeast     5 VGSSKLEQNNIKSIIGSSYNRLY-SQFTSDELTE----------VGNYKILKQIGEGSFGKVYLA 58

Human   637 RLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNIIRL-EGVVTKSRPVMIITEFM 700
             |..|..|:  |.:||     |:|...:.:.|.....|||.|.|.:| |.:||:|: |.:..|:.
Yeast    59 -LHRPTHRK--VCLKT-----SDKNDPNIVREVFYHRQFDFPYITKLYEVIVTESK-VWMALEYC 114

Human   701 ENGAL-DSFLRQNDGQFTVIQLVGMLRGIAAGMKYLAEMNYVHRDLAARNILVNSNLVCKVSDFG 764
            ....| |..|...  :.::::...:...|:..:.|...|:.|||||...|||::.|...|::|||
Yeast   115 PGKELYDHLLSLR--RISLLECGELFAQISGAVYYAHSMHCVHRDLKLENILLDKNGNAKLTDFG 177

Human   765 LSRYLQDDTSDPTYTSSLGGKIPVRWTAPEAIAYRKFTSAS-DVWSYGIVMWEVMSFGERPY--- 825
            .:|.....|   |..:..|..:   :.|||.|..|.:.... |:||.|::::.::: |..|:
Yeast   178 FTRECMTKT---TLETVCGTTV---YMAPELIERRTYDGFKIDIWSLGVILYTLIT-GYLPFDDD 235

Human   826 ------WDMSNQDVINAIEQDYRLPPPMDC---PAALHQLMLDCWQKDRNSRPRFAEIVNTLDKM 881
                  |.:.|::            |..|.   |.....|:.....|:...||       :|.::
Yeast   236 DEAKTKWKIVNEE------------PKYDAKVIPDDARDLISRLLAKNPGERP-------SLSQV 281

Human   882 IRNPASLKTVATITAVPSQPLLDRSIPDFTAF 913
            :|:| .|:...::....:|.:|.|.....|.|
Yeast   282 LRHP-FLQPYGSVVLDQTQKILCRQRSGGTQF 312

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EPHB1	NP_004432.1	EphR_LBD_B1	20..195	CDD:198444
		FN3	323..429	CDD:238020
		fn3	435..518	CDD:278470
		EphA2_TM	546..614	CDD:291255	10/41 (24%)
		PTKc_EphR_B	614..882	CDD:173638	75/282 (27%)
		Pkinase_Tyr	619..878	CDD:285015	73/273 (27%)
		SAM_EPH-B1	908..975	CDD:188950	2/6 (33%)
		SAM	908..973	CDD:197735	2/6 (33%)
		PDZ-binding. /evidence=ECO:0000255	982..984
YPL150W	NP_015175.1	STKc_AMPK-like	40..286	CDD:270905	76/283 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910