DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment EPHB1 and KIN4

DIOPT Version :9

Sequence 1:	NP_004432.1	Gene:	EPHB1 / 2047	HGNCID:	3392	Length:	984	Species:	Homo sapiens
Sequence 2:	NP_014876.1	Gene:	KIN4 / 854408	SGDID:	S000005759	Length:	800	Species:	Saccharomyces cerevisiae

Alignment Length:	372	Identity:	91/372 - (24%)
Similarity:	148/372 - (39%)	Gaps:	103/372 - (27%)

- Green bases have known domain annotations that are detailed below.

Human   621 IEEVIGAGEFGEVYKGRLKLPGKREI--YVAIKTLKAGYSEKQRRDFLS-----------EASIM 672
            |...:|.||||:|..|..|.....|:  .||||.:        |||.:.           |.:.:
Yeast    48 IGSTLGEGEFGKVKLGWTKASSSNEVPKQVAIKLI--------RRDTIKKDADKEIKIYREINAL 104

Human   673 GQFDHPNIIRLEGVVTKSRPVMIITEFMENGALDSF------LRQNDGQFTVIQLVGMLRGIAAG 731
            ....|||||.||.|:..|:.:.|:.||:..|....:      |:::.......||:       :|
Yeast   105 KHLTHPNIIYLEEVLQNSKYIGIVLEFVSGGEFYKYIQRKRRLKESSACRLFAQLI-------SG 162

Human   732 MKYLAEMNYVHRDLAARNILV--NSNLVCKVSDFG-LSRYLQDDTSDPTYTSSLGGKIPVRWTAP 793
            :.|:.....|||||...|:|:  :.|||  ::||| ::.:.:|:....|...|     |. :.||
Yeast   163 VNYMHYKGLVHRDLKLENLLLDKHENLV--ITDFGFVNEFFEDNELMKTSCGS-----PC-YAAP 219

Human   794 EAIAYRKFTSA--SDVWSYGIVMWEVMSFGERPYWDMSNQD--------VINAIEQ------DYR 842
            |.:...|...|  :||||.|::::.::: |..| ||..:::        :...|.|      :|.
Yeast   220 ELVVSTKAYEARKADVWSCGVILYAMLA-GYLP-WDDDHENPTGDDIARLYKYITQTPLKFPEYI 282

Human   843 LPPPMDCPAAL----------------------HQLML----DCW----QKDRNSRPR------- 870
            .|.|.|....:                      |:..|    :.|    ||:|...|.
Yeast   283 TPIPRDLLRRILVPNPRRRINLQTIKRHVWLKPHEAFLSIQPNYWDEHLQKERPKPPNKGDVGRH 347

Human   871 --FAEIVNTLDKMIRNPASLKTVATITAVPSQPLLDRSIPDFTAFTT 915
              ::...::..|. |:..||...:|:......|.|..|.|....|:|
Yeast   348 STYSSSASSYSKS-RDRNSLIIESTLEQHRMSPQLATSRPASPTFST 393

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EPHB1	NP_004432.1	EphR_LBD_B1	20..195	CDD:198444
		FN3	323..429	CDD:238020
		fn3	435..518	CDD:278470
		EphA2_TM	546..614	CDD:291255
		PTKc_EphR_B	614..882	CDD:173638	81/337 (24%)
		Pkinase_Tyr	619..878	CDD:285015	80/333 (24%)
		SAM_EPH-B1	908..975	CDD:188950	3/8 (38%)
		SAM	908..973	CDD:197735	3/8 (38%)
		PDZ-binding. /evidence=ECO:0000255	982..984
KIN4	NP_014876.1	STKc_Kin4	44..313	CDD:270978	73/289 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910