Protein Alignment EPHB1 and Alk

DIOPT Version :10

• Sequence 1: NP_004432.1
• Gene: EPHB1 / 2047
• HGNCID: 3392
• Length: 984
• Species: Homo sapiens
• Sequence 2: NP_652600.1
• Gene: Alk / 53425
• FlyBaseID: FBgn0040505
• Length: 1701
• Species: Drosophila melanogaster
• Alignment Length: 525
• Identity: 143/525 - (27%)
• Similarity: 236/525 - (44%)
• Gaps: 116/525 - (22%)

Human   471 YYEKEHNEFNSSMARSQTNTARIDGLR------PGMVYVVQVRARTVAGYG---------KFSGK 520
            |..:.:.|..||......:...|..:.      ||.:.::.    .:.|.|         :|..|
  Fly  1012 YLTESNGEGGSSYISPSRSLREISEIHAGASSGPGAIIIIP----AIEGCGCDYRCVALDEFRSK 1072

Human   521 M-CF----QTLTDDDYKS-ELREQLPLIAGSAAAGVVFVVSLVAISI----VC------------ 563
            : |.    .:|..|::.: |:||:    ||.::  ..::||::.||:    :|
  Fly  1073 VRCICPDGWSLKRDNHTACEIREE----AGKSS--FQYLVSILMISLAVLFICIAALIFMLYNRY 1131

Human   564 -----SRKRAYSKEAVYSD-------------KLQHYSTGRGSPG-MKIYIDPFTYEDPNEAVRE 609
                 |:||  .|..|..|             .|.:::...|..| :..:||.       .::.:
  Fly  1132 QRKKQSKKR--HKMLVEQDLQLTRLRNNIDDSNLNNFNPNYGCDGILNGHIDV-------NSLPQ 1187

Human   610 FAKEIDVSFVKIEEVIGAGEFGEVYKG--RLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIM 672
            .|::    .:::...:|.|.|||||..  |.:.....|:.||:|||:.....::..|||.||:||
  Fly  1188 VARD----SLQLVNALGKGAFGEVYMALYRHRDGDAVEMGVAVKTLREDPKREKEEDFLKEAAIM 1248

Human   673 GQFDHPNIIRLEGVVTKSRPVMIITEFMENGALDSFLRQN------DGQFTVIQLVGMLRGIAAG 731
            .:|:|||::.|.||....:|..|:.|.:..|.|..|||:|      ....|:..|:.....:|.|
  Fly  1249 AKFNHPNMVHLIGVCFDRQPYYIVLELLAGGDLQKFLRENRNTPERPSLLTMKDLLFCALDVAKG 1313

Human   732 MKYLAEMNYVHRDLAARNILVNS---NLVCKVSDFGLSRYLQDDTSDPTYTSSL---GGK--IPV 788
            .:|:....::|||:||||.|::|   ..|.|::|||:||.:        |.|..   |||  :|:
  Fly  1314 CRYMESKRFIHRDIAARNCLLSSKGPGRVVKIADFGMSRDI--------YRSDYYRKGGKAMLPI 1370

Human   789 RWTAPEAIAYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPMDCPAAL 853
            :|..|||.....|||.:||||:||::|||.|.|..||....|..|:..:.:..||..|.:||.::
  Fly  1371 KWMPPEAFLDGIFTSKTDVWSFGILLWEVFSLGRSPYPGQHNTQVMELVVRGGRLGSPTECPVSI 1435

Human   854 HQLMLDCWQKDRNSRPRFAEIVN-----TLDKMIRN--------PASLKTVATITAVPSQPLLDR 905
            :::|.|||......||.|..::.     |.|..|.|        |.:.:...|:...|:......
  Fly  1436 YKVMADCWNPTPEDRPTFITLLEHLTACTQDASIMNAPLPNILGPTASERDDTVIRPPNGEEFCL 1500

Human   906 SIPDF 910
            ::||:
  Fly  1501 AVPDY 1505

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EPHB1	NP_004432.1	EphR_LBD_B1	20..195	CDD:198444
		fn3	326..412	CDD:394996
		fn3	435..518	CDD:394996	9/61 (15%)
		EphA2_TM	542..616	CDD:464211	19/108 (18%)
		PTKc_EphR_B	614..882	CDD:173638	100/288 (35%)
		SAM_EPH-B1	908..975	CDD:188950	2/3 (67%)
		PDZ-binding. /evidence=ECO:0000255	982..984
Alk	NP_652600.1	MAM	288..447	CDD:99706
		MAM	505..689	CDD:99706
		PTKc_ALK_LTK	1186..1462	CDD:270632	99/287 (34%)