DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment EPHB1 and ephb1

DIOPT Version :9

Sequence 1:	NP_004432.1	Gene:	EPHB1 / 2047	HGNCID:	3392	Length:	984	Species:	Homo sapiens
Sequence 2:	XP_002935121.2	Gene:	ephb1 / 493336	XenbaseID:	XB-GENE-488626	Length:	987	Species:	Xenopus tropicalis

Alignment Length:	987	Identity:	898/987 - (90%)
Similarity:	937/987 - (94%)	Gaps:	3/987 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MALDYLLLLLL---ASAVAAMEETLMDTRTATAELGWTANPASGWEEVSGYDENLNTIRTYQVCN 62
            |.|:.||||||   .|.|.|:||||||||||||||||||||:|||||||||||||||||||||||
Frog     1 MELNVLLLLLLCSIGSQVGAVEETLMDTRTATAELGWTANPSSGWEEVSGYDENLNTIRTYQVCN 65

Human    63 VFEPNQNNWLLTTFINRRGAHRIYTEMRFTVRDCSSLPNVPGSCKETFNLYYYETDSVIATKKSA 127
            ||.|:||||||||||.||||||:|.||||||||||||||||||||||||||||||||.|..|.|.
Frog    66 VFGPSQNNWLLTTFIPRRGAHRVYVEMRFTVRDCSSLPNVPGSCKETFNLYYYETDSNIDNKIST 130

Human   128 FWSEAPYLKVDTIAADESFSQVDFGGRLMKVNTEVRSFGPLTRNGFYLAFQDYGACMSLLSVRVF 192
            ||:|:||||||||||||||||||||||||||||||||||||||:|||||||||||||||||||||
Frog   131 FWNESPYLKVDTIAADESFSQVDFGGRLMKVNTEVRSFGPLTRSGFYLAFQDYGACMSLLSVRVF 195

Human   193 FKKCPSIVQNFAVFPETMTGAESTSLVIARGTCIPNAEEVDVPIKLYCNGDGEWMVPIGRCTCKP 257
            ||||||:||||||||||||||||||||||||||||||||||||||||||||||||||||:||||.
Frog   196 FKKCPSVVQNFAVFPETMTGAESTSLVIARGTCIPNAEEVDVPIKLYCNGDGEWMVPIGKCTCKA 260

Human   258 GYEPENSVACKACPAGTFKASQEAEGCSHCPSNSRSPAEASPICTCRTGYYRADFDPPEVACTSV 322
            ||||||.|.||||||..|||:|....|:.||:||||.:||||||.||.||||||||.||..||||
Frog   261 GYEPENHVVCKACPAAMFKANQGMGVCAPCPANSRSTSEASPICICRNGYYRADFDTPEAPCTSV 325

Human   323 PSGPRNVISIVNETSIILEWHPPRETGGRDDVTYNIICKKCRADRRSCSRCDDNVEFVPRQLGLT 387
            ||||||||||||||:|.||||||||||||||||||||||||::|||.||||||||||||||:|||
Frog   326 PSGPRNVISIVNETAITLEWHPPRETGGRDDVTYNIICKKCQSDRRGCSRCDDNVEFVPRQMGLT 390

Human   388 ECRVSISSLWAHTPYTFDIQAINGVSSKSPFPPQHVSVNITTNQAAPSTVPIMHQVSATMRSITL 452
            :.||.||:|||||||||:|||||||::|||||||||||||||||||||:|||||||.|||:||||
Frog   391 DTRVFISNLWAHTPYTFEIQAINGVTNKSPFPPQHVSVNITTNQAAPSSVPIMHQVKATMKSITL 455

Human   453 SWPQPEQPNGIILDYEIRYYEKEHNEFNSSMARSQTNTARIDGLRPGMVYVVQVRARTVAGYGKF 517
            ||||||||||||||||||||||:|:|||||:||||||||.|:|||||:|||||||||||||||||
Frog   456 SWPQPEQPNGIILDYEIRYYEKDHHEFNSSLARSQTNTASIEGLRPGVVYVVQVRARTVAGYGKF 520

Human   518 SGKMCFQTLTDDDYKSELREQLPLIAGSAAAGVVFVVSLVAISIVCSRKRAYSKEAVYSDKLQHY 582
            |.||||||||.:|||||||||||||||||||||||:||||||||||||||.||||||||||||||
Frog   521 SSKMCFQTLTAEDYKSELREQLPLIAGSAAAGVVFIVSLVAISIVCSRKRTYSKEAVYSDKLQHY 585

Human   583 STGRGSPGMKIYIDPFTYEDPNEAVREFAKEIDVSFVKIEEVIGAGEFGEVYKGRLKLPGKREIY 647
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.|||||
Frog   586 STGRGSPGMKIYIDPFTYEDPNEAVREFAKEIDVSFVKIEEVIGAGEFGEVYKGRLKLPSKREIY 650

Human   648 VAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIITEFMENGALDSFLRQN 712
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Frog   651 VAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIITEFMENGALDSFLRQN 715

Human   713 DGQFTVIQLVGMLRGIAAGMKYLAEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPT 777
            |||||||||||||||||||||||:|||||||||||||||||||||||||||||||||||||||||
Frog   716 DGQFTVIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPT 780

Human   778 YTSSLGGKIPVRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYR 842
            ||||||||||||||||||||||||||||||||||||||||||:||||||||||||||||||||||
Frog   781 YTSSLGGKIPVRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAIEQDYR 845

Human   843 LPPPMDCPAALHQLMLDCWQKDRNSRPRFAEIVNTLDKMIRNPASLKTVATITAVPSQPLLDRSI 907
            |||||||||||||||||||||||||||||.||||||||||||||||||||||.|||||||||.||
Frog   846 LPPPMDCPAALHQLMLDCWQKDRNSRPRFGEIVNTLDKMIRNPASLKTVATIPAVPSQPLLDHSI 910

Human   908 PDFTAFTTVDDWLSAIKMVQYRDSFLTAGFTSLQLVTQMTSEDLLRIGITLAGHQKKILNSIHSM 972
            ||.||||:||||||||||.||||.||::||||||||.|||||||||||||||||||||||||.||
Frog   911 PDITAFTSVDDWLSAIKMGQYRDIFLSSGFTSLQLVAQMTSEDLLRIGITLAGHQKKILNSIQSM 975

Human   973 RVQISQSPTAMA 984
            |||||||||::|
Frog   976 RVQISQSPTSIA 987

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EPHB1	NP_004432.1	EphR_LBD_B1	20..195	CDD:198444	160/174 (92%)
		FN3	323..429	CDD:238020	92/105 (88%)
		fn3	435..518	CDD:278470	73/82 (89%)
		EphA2_TM	546..614	CDD:291255	65/67 (97%)
		PTKc_EphR_B	614..882	CDD:173638	263/267 (99%)
		Pkinase_Tyr	619..878	CDD:285015	254/258 (98%)
		SAM_EPH-B1	908..975	CDD:188950	58/66 (88%)
		SAM	908..973	CDD:197735	56/64 (88%)
		PDZ-binding. /evidence=ECO:0000255	982..984		0/1 (0%)
ephb1	XP_002935121.2	EphR_LBD_B1	23..198	CDD:198444	160/174 (92%)
		FN3	326..432	CDD:238020	92/105 (88%)
		FN3	420..528	CDD:238020	97/107 (91%)
		EphA2_TM	549..617	CDD:373140	65/67 (97%)
		PTKc_EphR_B	617..885	CDD:173638	263/267 (99%)
		SAM_EPH-B1	911..978	CDD:188950	58/66 (88%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	520	1.000	Domainoid score	I3426
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H20936
Inparanoid	1	1.050	1829	1.000	Inparanoid score	I867
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D33462at32523
OrthoFinder	1	1.000	-	-		FOG0000086
OrthoInspector	1	1.000	-	-		oto150081
Panther	1	1.100	-	-	LDO	PTHR24416
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X82
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	10.160