Protein Alignment EPHB1 and InR

DIOPT Version :10

• Sequence 1: NP_004432.1
• Gene: EPHB1 / 2047
• HGNCID: 3392
• Length: 984
• Species: Homo sapiens
• Sequence 2: NP_524436.2
• Gene: InR / 42549
• FlyBaseID: FBgn0283499
• Length: 2144
• Species: Drosophila melanogaster
• Alignment Length: 1169
• Identity: 250/1169 - (21%)
• Similarity: 407/1169 - (34%)
• Gaps: 383/1169 - (32%)

Human    46 SGYDENLNTIRTYQVCNVF---EPNQNNWLLTTFINRRGAHRIYTEMRF---------------- 91
            ||..::|...|.:..|.:.   ||      ||..|.|.....:..|:::
  Fly   649 SGLIDSLERAREFHGCTIITGTEP------LTISIKRESGAHVMDELKYGLAAVHKIQSSLMVHL 707

Human    92 -----TVRDCSSLPNVPGS---CKETFNLYYYE----------TDSVIATKKSAFWSEAPYLKVD 138
                 :::...||..:.|.   ..:.:.||..:          ..:|...|...|:...|.|.|.
  Fly   708 TYGLKSLKFFQSLTEISGDPPMDADKYALYVLDNRDLDELWGPNQTVFIRKGGVFFHFNPKLCVS 772

Human   139 TI--------AADESFSQVDFG-------------------------GRLMKVNTEVRSFGPLTR 170
            ||        :..:.|.:.|.|                         ..::.|.|:|....|...
  Fly   773 TINQLLPMLASKPKFFEKSDVGADSNGNRGSCGTAVLNVTLQSVGANSAMLNVTTKVEIGEPQKP 837

Human   171 NGFYLAFQD---------------YG--------AC-------------MSLLSVRVFFKKCPSI 199
            :...:.|:|               ||        .|             :.:||..:.:......
  Fly   838 SNATIVFKDPRAFIGFVFYHMIDPYGNSTKSSDDPCDDRWKVSSPEKSGVMVLSNLIPYTNYSYY 902

Human   200 VQNFAVFPETMTGAES---------------TSLV------------------------------ 219
            |:..|:..| :|.|||               |.:|
  Fly   903 VRTMAISSE-LTNAESDVKNFRTNPGRPSKVTEVVATAISDSKINVTWSYLDKPYGVLTRYFIKA 966

Human   220 --IARGTCIPNAEEVDVPIKLYCNGDGEWMVP--------IGRCTC-----------------KP 257
              |.|.|...|.:....|:......|.....|        .|.|.|                 :.
  Fly   967 KLINRPTRNNNRDYCTEPLVKAMENDLPATTPTKKISDPLAGDCKCVEGSKKTSSQEYDDRKVQA 1031

Human   258 GYEPENSVA-------CKACPAGTFKASQEAEGC-----------SHCPSNSRSPAEASPICTCR 304
            |.|.||::.       .:....|:...|..|||.           :..||..|......|
  Fly  1032 GMEFENALQNFIFVPNIRKSKNGSSDKSDGAEGAALDSNAIPNGGATNPSRRRRDVALEP----- 1091

Human   305 TGYYRADFDPPEVACTSVPSGPRNVISIVNETSIILEWHPPRETGGRDDVT-----YNIICKKCR 364
                  :.|..|.:...     |:|.||.::|....|..........:|::     |.:..|:..
  Fly  1092 ------ELDDVEGSVLL-----RHVRSITDDTDAFFEKDDENTYKDEEDLSSNKQFYEVFAKELP 1145

Human   365 ADRRSCSRCDDNVEFVPRQLG--------LTECRVSISSLWAHTPYTFDIQAINGVSSKSPFPPQ 421
            .::         ..||..:|.        :..||..|.|           :.:...|.|......
  Fly  1146 PNQ---------THFVFEKLRHFTRYAIFVVACREEIPS-----------EKLRDTSFKKSLCSD 1190

Human   422 HVSVNITTNQAAPSTVPI-----MHQVSATMRSITLSWPQPEQPNGIILDYEIRYYEKEHNEFNS 481
            :.:|..||.:...:.:.:     :...:.|...:.:.|..|..|||.|:.||:.|..::.::...
  Fly  1191 YDTVFQTTKRKKFADIVMDLKVDLEHANNTESPVRVRWTPPVDPNGEIVTYEVAYKLQKPDQVEE 1255

Human   482 SMARSQTNTARIDG----LRPGMVYVVQVRARTVAGYGKFS-------------GKMCFQTLTDD 529
            .......:..:..|    |..|: |..:|||.::||||.|:             .|:.|..|
  Fly  1256 KKCIPAADFNQTAGYLIKLNEGL-YSFRVRANSIAGYGDFTEVEHIKVEPPPSYAKVFFWLL--- 1316

Human   530 DYKSELREQLPLIAGSAAAGVVF-VVSLVAISIVCSRKRAYSKEAVYSDKLQHYSTGRGSPGMKI 593
                             ..|:.| :|||  ...||    ...|..|.|:.|.          |..
  Fly  1317 -----------------GIGLAFLIVSL--FGYVC----YLHKRKVPSNDLH----------MNT 1348

Human   594 YIDPF-----TYEDPNEAVREFAKEIDVSFVKIEEVIGAGEFGEVYKGRLKL--PGKREIYVAIK 651
            .::||     ...|..|.:||       :.:::.. :|.|.||.||:|.||.  |...:...|||
  Fly  1349 EVNPFYASMQYIPDDWEVLRE-------NIIQLAP-LGQGSFGMVYEGILKSFPPNGVDRECAIK 1405

Human   652 TLKAGYSEKQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIITEFMENGALDSFLR------ 710
            |:....::::|.:||||||:|.:||..:::||.||.::.:|.:::.|.|:.|.|.|:||
  Fly  1406 TVNENATDRERTNFLSEASVMKEFDTYHVVRLLGVCSRGQPALVVMELMKKGDLKSYLRAHRPEE 1470

Human   711 QNDGQFTVIQLVG---------------MLRGIAAGMKYLAEMNYVHRDLAARNILVNSNLVCKV 760
            :::...|.:..:|               |...||.||.|||...:|||||||||.:|..:|..|:
  Fly  1471 RDEAMMTYLNRIGVTGNVQPPTYGRIYQMAIEIADGMAYLAAKKFVHRDLAARNCMVADDLTVKI 1535

Human   761 SDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSFGERPY 825
            .|||::|   |......|.....|.:||||..||::....::|||||:|:|:|:||:.:...:||
  Fly  1536 GDFGMTR---DIYETDYYRKGTKGLLPVRWMPPESLRDGVYSSASDVFSFGVVLWEMATLAAQPY 1597

Human   826 WDMSNQDVINAIEQDYRLPPPMDCPAALHQLMLDCWQKDRNSRPRFAEIVNTLDKMIRNPASLKT 890
            ..:||:.|:..:.....:..|.:||..||:||..||....::||.|.:|:..|:....| :..|.
  Fly  1598 QGLSNEQVLRYVIDGGVMERPENCPDFLHKLMQRCWHHRSSARPSFLDIIAYLEPQCPN-SQFKE 1661

Human   891 VA----------------------TITAVP-SQPLLDRSIPDFTAFTTVDDWLSAIKMVQYRDS 931
            |:                      ...||| .|.|.||.        ..:|..:.::|..|:.:
  Fly  1662 VSFYHSEAGLQHREKERKERNQLDAFAAVPLDQDLQDRE--------QQEDATTPLRMGDYQQN 1717

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EPHB1	NP_004432.1	EphR_LBD_B1	20..195	CDD:198444	39/254 (15%)
		fn3	326..412	CDD:394996	16/98 (16%)
		fn3	435..518	CDD:394996	21/91 (23%)
		EphA2_TM	542..616	CDD:464211	18/79 (23%)
		PTKc_EphR_B	614..882	CDD:173638	100/290 (34%)
		SAM_EPH-B1	908..975	CDD:188950	3/24 (13%)
		PDZ-binding. /evidence=ECO:0000255	982..984
InR	NP_524436.2	Recep_L_domain	356..465	CDD:460032
		Furin-like	510..645	CDD:395614
		Recep_L_domain	663..781	CDD:460032	21/123 (17%)
		FN3	791..>964	CDD:442628	22/173 (13%)
		FN3	1224..1302	CDD:238020	21/78 (27%)
		PTKc_InsR_like	1364..1652	CDD:173625	103/298 (35%)