Protein Alignment EPHB1 and dnt

DIOPT Version :10

• Sequence 1: NP_004432.1
• Gene: EPHB1 / 2047
• HGNCID: 3392
• Length: 984
• Species: Homo sapiens
• Sequence 2: NP_477341.2
• Gene: dnt / 35207
• FlyBaseID: FBgn0024245
• Length: 584
• Species: Drosophila melanogaster
• Alignment Length: 612
• Identity: 146/612 - (23%)
• Similarity: 255/612 - (41%)
• Gaps: 135/612 - (22%)

Human   362 KC--RADRRSCSRCDDNVEFVPRQLGLTECRV-SISSLWAH-----TPYTFDIQAINGVSSKSPF 418
            ||  .|..|:|:.......:|...|.|...:: |.|.:.||     .|  .::..:.|||::..:
  Fly     6 KCGKSASTRNCTVKMSRKMWVLSLLALAALQLHSGSEVAAHLNVFLNP--VEVMRLLGVSAEVYY 68

Human   419 PPQ-HVSVNITTNQAAPSTVPIMHQVSATMRSITLSWPQ------PEQPNGIILDYEI---RYYE 473
            ..: |::     |.|....||    |.|.::.|:.:|..      |...|.:..|.|:   ....
  Fly    69 VREGHIN-----NYALNFIVP----VPANVKDISFTWQSLAGRGLPYSINVVSSDQEVLPRPAIN 124

Human   474 KEHNEFNSSMARSQTNTARIDGLRPGMV------YVVQVRARTVAGYGKF-SGKMCF-----QTL 526
            ..|:....:..::.:...:..||:...|      .||..|:.....:..| ..|:|.     :.|
  Fly   125 VSHSGEIPTTIQTWSIALKCSGLKAAEVDVTVSLEVVLNRSLNNVTHLVFRRKKICLMNDSAEDL 189

Human   527 TDDDYKSELRE--QLP------LIAG-SAAAGVVFVVSLVAISIVCSRKRAYSKEAVYSDKLQHY 582
            ::|....:|.|  .||      |:.| |.|.|.|.::.::|..:         |.|  ::|.||:
  Fly   190 SEDVDDPQLLETVMLPPTGLITLVVGVSVAMGSVCLLLMIAYCV---------KGA--ANKRQHH 243

Human   583 STG------------------RGSPGMKIYIDP------------------FTYEDPNEAVREFA 611
            ..|                  :.|.|...|:.|                  ...:.|.|..|..:
  Fly   244 QHGGQPMRTSSFQRLNTHPPCQSSMGSAAYMTPSIIAPIHGSSLPRKVPVSVEQQHPEELHRRIS 308

Human   612 K-EIDVSFVKIEEVIGAGEFGEVYKGRLKLPGKREIY-----VAIKTLKAGYSEKQRRDFLSEAS 670
            : .::...|::..::..|.||.||:|         .|     |.:||:....|:.|....|.|..
  Fly   309 ELTVERCRVRLSSLLQEGTFGRVYRG---------TYNDTQDVLVKTVAQHASQMQVLLLLQEGM 364

Human   671 IMGQFDHPNIIRLEGVVTKSRPVMIITEFMENGALDSFLRQNDGQF----------TVIQLVGML 725
            ::....||.|:.:.||..:..    .|.|:...||::  .:|..||          |.||:|.|.
  Fly   365 LLYGASHPGILSVLGVSIEDH----TTPFVLYPALNN--TRNLKQFLLDPACARTVTTIQIVMMA 423

Human   726 RGIAAGMKYLAEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGG--KIPV 788
            ..::..:.:|.....||:|:|.||.:::..|..|:||..|||.|     .|:..:.||.  ..||
  Fly   424 SQLSMALDHLHSHGVVHKDIATRNCVIDDQLRVKLSDSSLSRDL-----FPSDYNCLGDSENRPV 483

Human   789 RWTAPEAIAYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPMDCPAAL 853
            :|.:.||:.:::|:.|||.|::|::|||:.:..::||.::...::.:.::..|||..|.:||..|
  Fly   484 KWMSLEALQHKQFSEASDSWAFGVLMWELCTSAKQPYAEVDPFEMEHYLKDGYRLAQPFNCPDEL 548

Human   854 HQLMLDCWQKDRNSRPRFAEIVNTLDK 880
            ..:|..||......||.||::.:.|.:
  Fly   549 FTIMAYCWALLPAERPTFAQLQSCLSE 575

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EPHB1	NP_004432.1	EphR_LBD_B1	20..195	CDD:198444
		fn3	326..412	CDD:394996	13/57 (23%)
		fn3	435..518	CDD:394996	18/98 (18%)
		EphA2_TM	542..616	CDD:464211	19/111 (17%)
		PTKc_EphR_B	614..882	CDD:173638	81/284 (29%)
		SAM_EPH-B1	908..975	CDD:188950
		PDZ-binding. /evidence=ECO:0000255	982..984
dnt	NP_477341.2	WIF	46..182	CDD:128745	28/146 (19%)
		Protein Kinases, catalytic domain	310..580	CDD:473864	81/286 (28%)