Protein Alignment EPHB1 and Pvr

DIOPT Version :10

• Sequence 1: NP_004432.1
• Gene: EPHB1 / 2047
• HGNCID: 3392
• Length: 984
• Species: Homo sapiens
• Sequence 2: NP_001162911.1
• Gene: Pvr / 34127
• FlyBaseID: FBgn0032006
• Length: 1577
• Species: Drosophila melanogaster
• Alignment Length: 1185
• Identity: 244/1185 - (20%)
• Similarity: 397/1185 - (33%)
• Gaps: 435/1185 - (36%)

Human    26 RTATAELGWTANPASGWEEVSGYDENLNTIRTYQVCNVF-------------------------- 64
            ||.|..:.:|..|.     |:..|:.:.|:......|:.
  Fly   256 RTQTTNMVYTYAPG-----VTDGDDEVLTVTNQSTGNLALIRGGDGTLSRERARRSPARLAPMNA 315

Human    65 ----EPNQNNWLLTTFINRRGA-HRIYTEMRFTVRDCSSLPNVPGSCKETFNLYYY----ETDSV 120
                .|.|:...|...:.|... |.::|:..||: ||.....|    :..:.:.::    :.:.:
  Fly   316 SPSPRPGQDGKPLPKPVIRSSVEHHVFTDTNFTL-DCEQSAYV----ESVYGMEWFTPSRDENRI 375

Human   121 IA--------TKKSAFWSEAPYLKV------DT-----IAADESFSQVDFGGRLMKVNTEVRSFG 166
            .|        |:.|...:....|.|      ||     :..|.|...|......:||
  Fly   376 FASQSRTDPKTRNSTHQTGRSTLTVLNAQPSDTGLYKCVTTDNSNQNVQRATYRIKV-------- 432

Human   167 PLTRNGFYLAFQDYGACMSLLSVRVFFKKCPSIVQNFAVFPETMTGAESTSLVIARGTCIPNAE- 230
             |.:|..||   :.|......:|:.:..:...:..||..||     ..|.|.....||.:..:|
  Fly   433 -LKQNESYL---NVGEPSGHYNVQEYANRTIQMTANFEGFP-----TPSFSWFKPDGTEVRQSEN 488

Human   231 -------EVDVPIKL-----------YCNGDGEWMVPIGRCTCKPGYEPENSVACKACPAGTFKA 277
                   |:...:::           ...|...:.|          .:.|.:|:....||  .|.
  Fly   489 NFKILSTELSTMLQVLNAQLQDSGTYVLRGSNSFGV----------VQREYNVSVMDAPA--LKM 541

Human   278 SQEAEGCSHCPSNSRSPAEASPICTCR-------TGYYR-ADFDPPEVACT------SVPS---- 324
            |.     ::....|.:..|    ||.|       |.::| ...:|....|:      |:||
  Fly   542 SD-----AYVQVGSVARLE----CTVRSYPPAIVTFFFRPCSLEPQWPTCSVLNQNFSLPSEQEK 597

Human   325 -----GPR-NVISI--VNETSIILEWHPPRETGGRDDVTYNIICKKCRADRRSCSRC-------- 373
                 .|| ..:|:  :.|.|.:     |.|.|....:..|||..|   :||:.::.
  Fly   598 YQFQTRPRPGKLSVERIYEVSFL-----PTEPGILTCIAQNIIDGK---ERRTLTKAHVLLGNIS 654

Human   374 ----------------DDNVEFVPRQLGLTECRVSISSLWAHTPYTFDIQA---INGVSSKSPFP 419
                            :|||.|....|.                |.||...   |||...|
  Fly   655 ENMTIYGFDKDHKIAKEDNVNFTCEALA----------------YHFDGNLKWFINGEDLK---- 699

Human   420 PQHVSVNITTNQAAPSTVPIMHQVSATMRSITLSWPQPEQPNGIILDYEIRYYEKEHN------- 477
             :..||:|.|:..       .:...:|:...|:|    ::..|   .||.|.|..:.:
  Fly   700 -ESDSVHIETSHT-------KYSYKSTVHITTIS----DRDRG---TYECRAYHNDKDAVYSSRE 749

Human   478 ------------------EFNSSMARSQTNTARIDGLRPGMVYVV--------QVRARTVAGYGK 516
                              |.:|.:.|..:.|..::.....:...:        :|....:....:
  Fly   750 IDLYVHDPSAPQWTNGGQEGHSKIKRKLSQTLELECASTAVPVAIVRWFKDDKEVTESKLRHIIE 814

Human   517 FSGKMCFQTLTDDD---YKSELREQLPLIAGSAAA---------------GVVFVVSLVAISIVC 563
            ...|:....|...|   ||..:..:|..|..|...               ||:..:.|:.:.:..
  Fly   815 KESKLLITHLYPGDEGVYKCVVENRLDRIERSFTVVISDLPGISMAWVWFGVILFLILIGLCVFL 879

Human   564 SRKRAYSKE-----AVYSDKLQHYSTGRGSPGMKIYIDP-FTYEDPNEAV---REFAKEIDVSFV 619
            :.:  |.||     |:.:..|.::.  .|:.|   :|:| .|.::..|.:   |||  |.....:
  Fly   880 AVR--YQKEHKRHLALKAAGLANFE--EGAVG---HINPDLTLDEQAELLPYNREF--EFPRENL 935

Human   620 KIEEVIGAGEFGEVYKGRLKLPGKRE--IYVAIKTLKAGYSEKQRRDFLSEASIM---GQFDHPN 679
            |:.:.:|||.||.|.||..|...:.|  ..||:|.:||....:..|..:||..||   ||  |.|
  Fly   936 KLGKQLGAGAFGVVLKGEAKGIRREEPTTTVAVKMVKATADNEVVRALVSELKIMVHLGQ--HLN 998

Human   680 IIRLEGVVTKS---RPVMIITEFMENGALDSFLRQN----------------------------- 712
            ::.|.|.|||:   |.:|:|.|:...|.:.:||.:|
  Fly   999 VVNLLGAVTKNIAKRELMVIVEYCRFGNIQNFLLRNRKCFINQINPDTDHIDPSIMTQRMSDNYE 1063

Human   713 ----------------------------------------------------------------- 712
                                                                             
  Fly  1064 LHRDTNGGGLKYANVGFPIHSYINEPHNNNTQPPTHRRNSDNDPRSGTRAGRTGSGTATYSYDRQ 1128

Human   713 -------------DGQF------------------------TVIQLVGMLRGIAAGMKYLAEMNY 740
                         |.|.                        |.:.|:.....:|.||.||:....
  Fly  1129 MDTCATVMTTVPEDDQIMSNNSVQPAWRSNYKTDSTEAMTVTTVDLISWAFQVARGMDYLSSKKV 1193

Human   741 VHRDLAARNILVNSNLVCKVSDFGLSR--YLQDDTSDPTYTSSLGGKIPVRWTAPEAIAYRKFTS 803
            :|.||||||||:..:.|.|:.||||:|  |..|:     |..|..||:|::|.|.|:::...|::
  Fly  1194 LHGDLAARNILLCEDNVVKICDFGLARSMYRGDN-----YKKSENGKLPIKWLALESLSDHVFST 1253

Human   804 ASDVWSYGIVMWEVMSFGERPYWDMS-NQDVINAIEQDYRLPPPMDCPAALHQLMLDCWQKDRNS 867
            .|||||||||:||:.|..:.||..:. ||::.|.:...||:..|......|:::||:||:|:..|
  Fly  1254 YSDVWSYGIVLWEMFSLAKVPYPGIDPNQELFNKLNDGYRMEKPKFANQELYEIMLECWRKNPES 1318

Human   868 RPRFAEIVNTLDKMI 882
            ||.|||:......|:
  Fly  1319 RPLFAELEKRFANML 1333

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EPHB1	NP_004432.1	EphR_LBD_B1	20..195	CDD:198444	38/222 (17%)
		fn3	326..412	CDD:394996	24/115 (21%)
		fn3	435..518	CDD:394996	13/115 (11%)
		EphA2_TM	542..616	CDD:464211	20/97 (21%)
		PTKc_EphR_B	614..882	CDD:173638	106/409 (26%)
		SAM_EPH-B1	908..975	CDD:188950
		PDZ-binding. /evidence=ECO:0000255	982..984
Pvr	NP_001162911.1	IG_like	346..432	CDD:214653	15/90 (17%)
		Ig strand C	363..366	CDD:409353	0/2 (0%)
		Ig strand E	396..400	CDD:409353	1/3 (33%)
		Ig strand F	410..415	CDD:409353	0/4 (0%)
		Ig strand G	425..428	CDD:409353	0/2 (0%)
		Ig	458..533	CDD:472250	14/89 (16%)
		Ig strand B	459..463	CDD:409353	0/3 (0%)
		Ig strand C	472..476	CDD:409353	2/3 (67%)
		Ig strand E	497..503	CDD:409353	0/5 (0%)
		Ig strand F	513..518	CDD:409353	0/4 (0%)
		Ig	671..>742	CDD:472250	24/105 (23%)
		Ig strand B	674..678	CDD:409353	2/3 (67%)
		Ig strand C	687..691	CDD:409353	0/3 (0%)
		Ig strand E	717..721	CDD:409353	1/3 (33%)
		Ig strand F	731..736	CDD:409353	2/4 (50%)
		Ig	779..851	CDD:472250	10/71 (14%)
		Ig strand B	781..785	CDD:409570	0/3 (0%)
		Ig strand C	794..798	CDD:409570	0/3 (0%)
		Ig strand E	816..821	CDD:409570	1/4 (25%)
		Ig strand F	831..836	CDD:409570	2/4 (50%)
		Ig strand G	844..847	CDD:409570	0/2 (0%)
		Protein Kinases, catalytic domain	927..1332	CDD:473864	109/413 (26%)