Protein Alignment EPHB1 and Ddr

DIOPT Version :10

• Sequence 1: NP_004432.1
• Gene: EPHB1 / 2047
• HGNCID: 3392
• Length: 984
• Species: Homo sapiens
• Sequence 2: NP_001014474.3
• Gene: Ddr / 3346209
• FlyBaseID: FBgn0053531
• Length: 1054
• Species: Drosophila melanogaster
• Alignment Length: 794
• Identity: 186/794 - (23%)
• Similarity: 297/794 - (37%)
• Gaps: 242/794 - (30%)

Human   117 TDSVIATKKSAFWSEAPYLKVDTIAADESFSQVDFGGRLMKVNTEVRSFGPLTRNGFYLAFQDYG 181
            ||.:...:|.:..||.|      :..||....:..||...:..|:|.|..|:.......:|  .|
  Fly   447 TDELANGEKQSVTSEYP------LQRDEVGRAISSGGERSQHTTQVISPKPIDHQEPETSF--VG 503

Human   182 ACMSLLSVRVFFKKCPSIVQNFAVFPETMTGAESTSLVIARGTCIPNAEE-VDV------PIKLY 239
            ..:::|.         :|:.....|         ..|::||...:.:.|. :|.      |..|
  Fly   504 VIITVLG---------TIIMLLVAF---------ILLIVARNKHVRSRENGLDAFQHNFSPDTL- 549

Human   240 CNGDGEWMVPIGRCTCKPGYEPENSVACKACPAGTFKASQEAEGCSHCPSNSRSPAEASPICTCR 304
             ||:|...|    .|...  :.|:|:...:.....|.|:......|.||.|.......||..|
  Fly   550 -NGNGVLKV----VTTMD--DNESSIDKNSLYHEPFNANMYTSAASACPMNDLQRQHVSPDYT-- 605

Human   305 TGYYRADFDPPEVACT--SVPSGPRNVISIVNETSIILEWHPPRETGGRDDVTYNIICKKCRADR 367
                    |.|::.|.  :||           ....:|...||..:|             |....
  Fly   606 --------DVPDIVCQDYAVP-----------HMQQLLPNAPPCGSG-------------CGTGT 638

Human   368 RSCSRCDDNVEFVPRQLGLTECRVSISSLWAHTPYTFDIQAINGVSSKSPFPPQHVSVNITTNQA 432
            .:......:.|||     :...:|:.|:.          .::|..:...|.||
  Fly   639 GTGPGRGSSPEFV-----VATGKVTASAR----------NSLNAATLPLPSPP------------ 676

Human   433 APSTVPIMHQVSATMRSITLSWPQPEQPNGIILDYEIRYYEKEHNEFNSSMARSQTNTARIDGLR 497
            .|.  |:....:||..|   |.|.|..|.|                ..||.:.|.:.||
  Fly   677 VPP--PLEKYYAATPVS---SKPMPVAPPG----------------SQSSGSLSSSTTA------ 714

Human   498 PGMVYVVQVRARTVAGYGKFSGKMCFQTLTDDDYKSELREQLPLIAGSAAAGVVFVVSLVAISIV 562
                                                         |.:..:|||.|
  Fly   715 ---------------------------------------------ATTPTSGVVGV--------- 725

Human   563 CSRKRAYSKEAVYSDKLQHYSTGRGSPGMKIYIDPFTYEDPNE-----AVREFAKEIDVSFVKIE 622
                          .|..||:....:          .:.|.||     .|:||.::   |.|.:|
  Fly   726 --------------GKPHHYNLDMSA----------NFADINEERANCQVQEFPRQ---SLVIVE 763

Human   623 EVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNIIRLEGVV 687
            : :|:|.|||::.....:  .....||:.||:.|.::..|::|.|:|..:.|...||:.||.|..
  Fly   764 K-LGSGVFGELHLCETNV--LNATLVAVATLRPGANDHLRKEFRSKAKQLAQLSDPNVARLVGAC 825

Human   688 TKSRPVMIITEFME-NGALDSFLRQNDGQFTVIQ---------LVGMLRGIAAGMKYLAEMNYVH 742
            .:..|:.|:.::.. .|.|:.||:::..:.:.:.         ||.:...||:|||:|.:||:||
  Fly   826 LRDEPICIVQDYSHCLGDLNQFLQEHVAETSGLMAKKSLSFGCLVYIATQIASGMKHLEQMNFVH 890

Human   743 RDLAARNILVNSNLVCKVSDFGL----SRYLQDDTSDPTYTSSLGGKIPVRWTAPEAIAYRKFTS 803
            ||||.|:.::...|..||...|.    |.|..|......:|......:|:||.|.|::...|||:
  Fly   891 RDLATRSCIIGPELCVKVCSIGTVINRSAYASDYCQLEGFTGRQSQPMPIRWMAWESVLLGKFTT 955

Human   804 ASDVWSYGIVMWEVMSFG-ERPYWDMSNQDV---INAIEQDYR----LPPPMDCPAALHQLMLDC 860
            .|||||:.:.:||:::|. |:||..:|::.|   |..|.:||:    ||.|.:||..::.||.:|
  Fly   956 KSDVWSFAVALWEILTFAREQPYEHLSDKSVIENIGLIYRDYKMHELLPMPPNCPREIYDLMCEC 1020

Human   861 WQKDRNSRPRFAEI 874
            ||:|.:|||.|.||
  Fly  1021 WQRDESSRPSFREI 1034

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EPHB1	NP_004432.1	EphR_LBD_B1	20..195	CDD:198444	17/77 (22%)
		fn3	326..412	CDD:394996	11/85 (13%)
		fn3	435..518	CDD:394996	14/82 (17%)
		EphA2_TM	542..616	CDD:464211	14/78 (18%)
		PTKc_EphR_B	614..882	CDD:173638	96/283 (34%)
		SAM_EPH-B1	908..975	CDD:188950
		PDZ-binding. /evidence=ECO:0000255	982..984
Ddr	NP_001014474.3	FA58C	109..261	CDD:238014
		PTKc_DDR	753..1040	CDD:270644	98/288 (34%)