DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment EPHB1 and ephb1

DIOPT Version :9

Sequence 1:	NP_004432.1	Gene:	EPHB1 / 2047	HGNCID:	3392	Length:	984	Species:	Homo sapiens
Sequence 2:	XP_017207747.1	Gene:	ephb1 / 100333537	-ID:	-	Length:	1011	Species:	Danio rerio

Alignment Length:	1005	Identity:	850/1005 - (84%)
Similarity:	916/1005 - (91%)	Gaps:	21/1005 - (2%)

- Green bases have known domain annotations that are detailed below.

Human     1 MALDYLLLLLLASAVAAMEETLMDTRTATAELGWTANPASGWEEVSGYDENLNTIRTYQVCNVFE 65
            |.:..:.:|...:||.||||||||||||||||||||.|:||||||||||||||||||||||||||
Zfish     5 MTVGLITILSAVTAVYAMEETLMDTRTATAELGWTAYPSSGWEEVSGYDENLNTIRTYQVCNVFE 69

Human    66 PNQNNWLLTTFINRRGAHRIYTEMRFTVRDCSSLPNVPGSCKETFNLYYYETDSVIATKKSAFWS 130
            .|||||||||||.||||.|||.|||||||||||:|.|||||||||||||||||||||||.:|||.
Zfish    70 SNQNNWLLTTFIARRGAQRIYVEMRFTVRDCSSIPRVPGSCKETFNLYYYETDSVIATKGTAFWM 134

Human   131 EAPYLKVDTIAADESFSQVDFGGRLMKVNTEVRSFGPLTRNGFYLAFQDYGACMSLLSVRVFFKK 195
            ||||||||||||||||||||||||||||||||||||||::||||||||||||||||||||||:||
Zfish   135 EAPYLKVDTIAADESFSQVDFGGRLMKVNTEVRSFGPLSKNGFYLAFQDYGACMSLLSVRVFYKK 199

Human   196 CPSIVQNFAVFPETMTGAESTSLVIARGTCIPNAEEVDVPIKLYCNGDGEWMVPIGRCTCKPGYE 260
            |||:|||||:||||||||||||||||||.||||:|||||||||||||||:||||||.||||.|:|
Zfish   200 CPSVVQNFAIFPETMTGAESTSLVIARGMCIPNSEEVDVPIKLYCNGDGDWMVPIGSCTCKAGFE 264

Human   261 PENSVACKACPAGTFKASQEAEGCSHCPSNSRSPAEASPICTCRTGYYRADFDPPEVACTSVPSG 325
            |:|...|:|||.|||||||....||.||:||||.:||:.||.||.||||||.:.|::.|||||||
Zfish   265 PDNGNICRACPPGTFKASQGPGLCSQCPANSRSTSEAATICVCRNGYYRADGEQPDMPCTSVPSG 329

Human   326 PRNVISIVNETSIILEWHPPRETGGRDDVTYNIICKKCRADRRSCSRCDDNVEFVPRQLGLTECR 390
            ||||||||||||:.||||.|||||||:||||||:||||:|||||||.|||||||.||||||||.|
Zfish   330 PRNVISIVNETSVTLEWHSPRETGGREDVTYNIVCKKCQADRRSCSHCDDNVEFQPRQLGLTESR 394

Human   391 VSISSLWAHTPYTFDIQAINGVSSKSPFPPQHVSVNITTNQAAPSTVPIMHQVSATMRSITLSWP 455
            |.||:|.|||.|||:|||:||||:|||:|.||||::|||||||||.||||||||:||:|||||||
Zfish   395 VFISNLLAHTLYTFEIQAVNGVSNKSPYPAQHVSIDITTNQAAPSIVPIMHQVSSTMKSITLSWP 459

Human   456 QPEQPNGIILDYEIRYYEKEHNEFNSSMARSQTNTARIDGLRPGMVYVVQVRARTVAGYGKFSGK 520
            |||||||||||||:||||||.:|.||:..||||||||:||||||.:||:|||||||||:||:|.|
Zfish   460 QPEQPNGIILDYELRYYEKELSEVNSTQMRSQTNTARVDGLRPGTMYVMQVRARTVAGFGKYSSK 524

Human   521 MCFQTLTDDDYKSELREQLPLIAGSAAAGVVFVVSLVAISIVCSRKRAYSKEAVYSDKLQHYSTG 585
            ||||||||||||||||||||||||||||||||:||||||||||.|||||:|||||||||||||||
Zfish   525 MCFQTLTDDDYKSELREQLPLIAGSAAAGVVFIVSLVAISIVCRRKRAYNKEAVYSDKLQHYSTG 589

Human   586 R---------------------GSPGMKIYIDPFTYEDPNEAVREFAKEIDVSFVKIEEVIGAGE 629
            |                     |||||||||||||||||||||||||||||||.|||||||||||
Zfish   590 RELTLRPDLSNCHTPMGCPTLPGSPGMKIYIDPFTYEDPNEAVREFAKEIDVSTVKIEEVIGAGE 654

Human   630 FGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVM 694
            ||||||||||||||||:||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   655 FGEVYKGRLKLPGKRELYVAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVM 719

Human   695 IITEFMENGALDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLAEMNYVHRDLAARNILVNSNLVCK 759
            |:|||||||||||||||||||||||||||||||||||||||:|||||||||||||||||||||||
Zfish   720 IVTEFMENGALDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCK 784

Human   760 VSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSFGERP 824
            |||||||||||:||||||||||||||||||||:||||||||||||||||||||||||||||||||
Zfish   785 VSDFGLSRYLQEDTSDPTYTSSLGGKIPVRWTSPEAIAYRKFTSASDVWSYGIVMWEVMSFGERP 849

Human   825 YWDMSNQDVINAIEQDYRLPPPMDCPAALHQLMLDCWQKDRNSRPRFAEIVNTLDKMIRNPASLK 889
            ||||||||||||||||||||||||||.|||||||||||||||:||||.:|||||||:||||.|||
Zfish   850 YWDMSNQDVINAIEQDYRLPPPMDCPTALHQLMLDCWQKDRNARPRFTDIVNTLDKLIRNPTSLK 914

Human   890 TVATITAVPSQPLLDRSIPDFTAFTTVDDWLSAIKMVQYRDSFLTAGFTSLQLVTQMTSEDLLRI 954
            .||:|..:||||||||||||||.|::|:|||:|:||.||||:||.:|||||||||||||||||||
Zfish   915 AVASIPTIPSQPLLDRSIPDFTTFSSVEDWLAAVKMSQYRDNFLNSGFTSLQLVTQMTSEDLLRI 979

Human   955 GITLAGHQKKILNSIHSMRVQISQSPTAMA 984
            |:|||||||||||||.||.:|:||..|..|
Zfish   980 GVTLAGHQKKILNSIQSMHLQMSQCQTGTA 1009

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EPHB1	NP_004432.1	EphR_LBD_B1	20..195	CDD:198444	160/174 (92%)
		FN3	323..429	CDD:238020	85/105 (81%)
		fn3	435..518	CDD:278470	67/82 (82%)
		EphA2_TM	546..614	CDD:291255	64/88 (73%)
		PTKc_EphR_B	614..882	CDD:173638	257/267 (96%)
		Pkinase_Tyr	619..878	CDD:285015	249/258 (97%)
		SAM_EPH-B1	908..975	CDD:188950	53/66 (80%)
		SAM	908..973	CDD:197735	52/64 (81%)
		PDZ-binding. /evidence=ECO:0000255	982..984		0/1 (0%)
ephb1	XP_017207747.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	516	1.000	Domainoid score	I2534
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H20936
Inparanoid	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG45908
OrthoDB	1	1.010	-	-		D397694at33208
OrthoFinder	1	1.000	-	-		FOG0000086
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100189
Panther	1	1.100	-	-	LDO	PTHR24416
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8646
SonicParanoid	1	1.000	-	-		X82
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.960