DRSC/TRiP Functional Genomics Resources

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Protein Alignment EPHA8 and Alk

DIOPT Version :10

Sequence 1:NP_065387.1 Gene:EPHA8 / 2046 HGNCID:3391 Length:1005 Species:Homo sapiens
Sequence 2:NP_652600.1 Gene:Alk / 53425 FlyBaseID:FBgn0040505 Length:1701 Species:Drosophila melanogaster


Alignment Length:466 Identity:135/466 - (28%)
Similarity:205/466 - (43%) Gaps:69/466 - (14%)


- Green bases have known domain annotations that are detailed below.


Human   526 AMEV--ETGKPRPRYDTRTIVWICLTLITGLVVLLLLLI---------CKKRHCGYSKAFQDSDE 579
            |.|:  |.||...:| ..:|:.|.|.::...:..|:.::         .||||    |...:.|.
  Fly  1090 ACEIREEAGKSSFQY-LVSILMISLAVLFICIAALIFMLYNRYQRKKQSKKRH----KMLVEQDL 1149

Human   580 EKMHYQNGQAPPPV--FLPLHHPPGKLPEPQFYAEPHTYEEPGRAGRSFTREIEASRIHIEKIIG 642
            :....:|......:  |.|.:...|.|              .|....:...::....:.:...:|
  Fly  1150 QLTRLRNNIDDSNLNNFNPNYGCDGIL--------------NGHIDVNSLPQVARDSLQLVNALG 1200

Human   643 SGDSGEVCYGRLRVPGQRD-----VPVAIKALKAGYTERQRRDFLSEASIMGQFDHPNIIRLEGV 702
            .|..|||.....|   .||     :.||:|.|:......:..|||.||:||.:|:|||::.|.||
  Fly  1201 KGAFGEVYMALYR---HRDGDAVEMGVAVKTLREDPKREKEEDFLKEAAIMAKFNHPNMVHLIGV 1262

Human   703 VTRGRLAMIVTEYMENGSLDTFLRTH------DGQFTIMQLVGMLRGVGAGMRYLSDLGYVHRDL 761
            ....:...||.|.:..|.|..|||.:      ....|:..|:.....|..|.||:....::|||:
  Fly  1263 CFDRQPYYIVLELLAGGDLQKFLRENRNTPERPSLLTMKDLLFCALDVAKGCRYMESKRFIHRDI 1327

Human   762 AARNVLVDS---NLVCKVSDFGLSR-VLEDDPDAAYTTTGGK--IPIRWTAPEAIAFRTFSSASD 820
            ||||.|:.|   ..|.|::|||:|| :...|    |...|||  :||:|..|||.....|:|.:|
  Fly  1328 AARNCLLSSKGPGRVVKIADFGMSRDIYRSD----YYRKGGKAMLPIKWMPPEAFLDGIFTSKTD 1388

Human   821 VWSFGVVMWEVLAYGERPYWNMTNRDVISSVEEGYRLPAPMGCPHALHQLMLDCWHKDRAQRPRF 885
            |||||:::|||.:.|..||....|..|:..|..|.||.:|..||.:::::|.|||:.....||.|
  Fly  1389 VWSFGILLWEVFSLGRSPYPGQHNTQVMELVVRGGRLGSPTECPVSIYKVMADCWNPTPEDRPTF 1453

Human   886 SQIVSVLDALIRSPESLRATATVSRCP------PPAFVRSCFDLRGGSGGGGGLTVGDWLDSIRM 944
            ..::..|.|..:.       |::...|      |.|..|....:|..:|....|.|.|:|..:..
  Fly  1454 ITLLEHLTACTQD-------ASIMNAPLPNILGPTASERDDTVIRPPNGEEFCLAVPDYLVPLPP 1511

Human   945 GRYRDHFAAGG 955
            |...:...|.|
  Fly  1512 GGSNNPSMASG 1522

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EPHA8NP_065387.1 EphR_LBD 31..203 CDD:470656
FN3 <326..>519 CDD:442628
fn3 439..524 CDD:394996
EphA2_TM <562..632 CDD:464211 12/80 (15%)
Mediates interaction with ANKS1A and ANKS1B. /evidence=ECO:0000250 564..570 4/5 (80%)
Mediates interaction with PIK3CG and required for endocytosis. /evidence=ECO:0000250 589..644 6/56 (11%)
PTKc_EphR_A 630..896 CDD:270651 99/282 (35%)
SAM_EPH-A8 933..995 CDD:188949 7/23 (30%)
PDZ-binding. /evidence=ECO:0000255 1003..1005
AlkNP_652600.1 MAM 288..447 CDD:99706
MAM 505..689 CDD:99706
PTKc_ALK_LTK 1186..1462 CDD:270632 98/282 (35%)
Blue background indicates that the domain is not in the aligned region.

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