Protein Alignment EPHA8 and drl

DIOPT Version :10

• Sequence 1: NP_065387.1
• Gene: EPHA8 / 2046
• HGNCID: 3391
• Length: 1005
• Species: Homo sapiens
• Sequence 2: NP_001260566.1
• Gene: drl / 44355
• FlyBaseID: FBgn0015380
• Length: 645
• Species: Drosophila melanogaster
• Alignment Length: 610
• Identity: 142/610 - (23%)
• Similarity: 245/610 - (40%)
• Gaps: 135/610 - (22%)

Human   346 LEWAPPLDPGGRSDITY---NAVCRRCPWALSRCEACGSGTRFVPQQTSLVQASLLVANLLAHMN 407
            |.:|.|: |...||:|:   :.|....|::::   ...|.|..:|:.
  Fly    54 LNFAVPV-PANISDVTFTWQSLVDHPLPYSIN---IATSDTEVLPRP------------------ 96

Human   408 YSFWIEAVNGVSDLSPEPR-----------RAAVVNITTNQAAPSQVVVIRQERAGQTSVSLLWQ 461
                |..::.:.|:..||:           |.|.|.:|.|       |.:..:||...:.:|:::
  Fly    97 ----ILNISRIGDVPVEPQTWGIALKCSGTRNAEVTVTIN-------VEVILDRATNNNTNLIFK 150

Human   462 EP-----EQPNGIILEY-----------------EIKYYEKDKE------MQSYSTLKAVTTRAT 498
            ..     |:.:....||                 :|.|.:::.|      .|:....:.|.|.:.
  Fly   151 RKKICLREEQDSAHEEYDDDDLDLLQTARKGHGGDIHYVDRNDEHVVANGHQAPEKQRPVVTESP 215

Human   499 VS-GLKPGTRYVFQVRARTSAGCGRFSQAMEVETGKPRPRYDTRTIVWICLTLITGLVV------ 556
            |. |...|::..|....|        ...:...:|              .:|||.|.::
  Fly   216 VGRGNSGGSKRDFDPMLR--------ENLVPPASG--------------LVTLIVGGILALVLVS 258

Human   557 -LLLLLICKKRHCGYSKAFQDSDEEKMHYQNGQAPPPVFLPLHH-----PPGKLPEPQFYAEP-- 613
             |:|:..|.|   |.||....:....:...:.|..|.:....|:     |....|.......|
  Fly   259 TLILIAYCAK---GPSKRHPSNGVHLIKTSSFQRLPTISSTAHNSIYVCPSTITPTYATLTRPFR 320

Human   614 ---HTYEEPGRAGRSFTREIEASRIHIEKIIGSGDSGEVCYGRLRVPGQRDVPVAIKALKAGYTE 675
               |..||..|..:..|  ::..|:.:..::..|:.|.:..|......:    |.:|.:....::
  Fly   321 EYEHEPEEFNRRLQELT--VQKCRVRLSCLVQEGNFGRIYRGTYNDCQE----VLVKTVAQHASQ 379

Human   676 RQRRDFLSEASIMGQFDHPNIIRLEGVVTRGRLAMIVTEYMENGS---LDTFLR--THDGQFTIM 735
            .|....|.|:.::.:..|||::.:.|:.........|. |...||   |.:||:  ::....|.:
  Fly   380 LQVNLLLQESMMLYEASHPNVLSVLGISIEDYATPFVL-YAATGSVRNLKSFLQDPSYARSVTTI 443

Human   736 QLVGMLRGVGAGMRYLSDLGYVHRDLAARNVLVDSNLVCKVSDFGLSRVLEDDPDAAYTTTG-GK 799
            |.|.|...:...|.:|.:.|.:|:|:||||.::|..|..|::|..|||   |.....|.:.| |:
  Fly   444 QTVLMGSQLAMAMEHLHNHGVIHKDIAARNCVIDDQLRVKLTDSALSR---DLFPGDYNSLGDGE 505

Human   800 I-PIRWTAPEAIAFRTFSSASDVWSFGVVMWEVLAYGERPYWNMTNRDVISSVEEGYRLPAPMGC 863
            . ||:|.:.||:....::..||||||||:|||:...|:.||..:...::...:::||||..|..|
  Fly   506 YRPIKWLSLEALQKSHYNEGSDVWSFGVLMWEMCTLGKLPYAEIDPYEMEHYLKDGYRLAQPFNC 570

Human   864 PHALHQLMLDCWHKDRAQRPRFSQI 888
            |..|..:|..||....|:||.|||:
  Fly   571 PDELFTIMAYCWASMPAERPSFSQL 595

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EPHA8	NP_065387.1	EphR_LBD	31..203	CDD:470656
		FN3	<326..>519	CDD:442628	39/215 (18%)
		fn3	439..524	CDD:394996	18/113 (16%)
		EphA2_TM	<562..632	CDD:464211	16/79 (20%)
		Mediates interaction with ANKS1A and ANKS1B. /evidence=ECO:0000250	564..570		1/5 (20%)
		Mediates interaction with PIK3CG and required for endocytosis. /evidence=ECO:0000250	589..644		11/64 (17%)
		PTKc_EphR_A	630..896	CDD:270651	80/266 (30%)
		SAM_EPH-A8	933..995	CDD:188949
		PDZ-binding. /evidence=ECO:0000255	1003..1005
drl	NP_001260566.1	WIF	21..157	CDD:128745	25/135 (19%)
		PTK_Ryk	336..606	CDD:270639	81/270 (30%)