DRSC/TRiP Functional Genomics Resources

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Protein Alignment EPHA8 and btl

DIOPT Version :10

Sequence 1:NP_065387.1 Gene:EPHA8 / 2046 HGNCID:3391 Length:1005 Species:Homo sapiens
Sequence 2:NP_729956.1 Gene:btl / 39564 FlyBaseID:FBgn0285896 Length:1052 Species:Drosophila melanogaster


Alignment Length:767 Identity:178/767 - (23%)
Similarity:295/767 - (38%) Gaps:202/767 - (26%)


- Green bases have known domain annotations that are detailed below.


Human   247 CSAEGEWLVPIGKCVCSAGYEERRDACVACELGFYKSAPGDQLCARCPPHSHSAAPAAQAC---- 307
            |.||.:    :|:.| :|.|           :..|  :|.|....|....:..|:|...|.    
  Fly   329 CIAENQ----VGRTV-AASY-----------VDLY--SPSDTTTVRTTTTTTVASPIPTASTGED 375

Human   308 HCDLSYYRAALDPPSSACTRPPSAPV------NLISSVNGTSVTLEWAPPLDPGGRSDITYN--- 363
            :.|      .::.|::..:.....||      .|..|::|.:|.|  |.|:  .|:::||:.   
  Fly   376 NDD------DVENPAAEASGGVGPPVFRKELKRLQHSLSGNTVNL--ACPV--YGKANITWTKDK 430

Human   364 -------AVCRRCPWALSRCEACGSGTRFVPQQTSLVQASLLVANLLAHMNYSFWIEAVNGVSDL 421
                   .|..:..|.|...||       ..:.:.|....  |.|....:.:.|.::        
  Fly   431 KPLNRELGVYVQKNWTLRFVEA-------TSEDSGLYNCK--VCNAWGCIQFDFSVQ-------- 478

Human   422 SPEPRRAAVVNITTNQAAPSQVVVIRQERAGQTSVSLLWQEPEQPNGIILEYEIKYYEKDKEMQS 486
                     :|..| ::||  ::|:.|.:..:.:.||:                      .:...
  Fly   479 ---------INDRT-RSAP--IIVVPQNQTVKVNGSLV----------------------MKCTV 509

Human   487 YSTL-------KAVTTRATVSGLK-----------PGTRYVFQVRART-----------SAGCGR 522
            ||.|       :.|...|::.|||           .....|..:|..|           |:|.||
  Fly   510 YSDLHPTVSWKRVVLKNASLDGLKSVEIQNLNFTVTNDSVVLTLRNVTFDQEGWYTCLASSGLGR 574

Human   523 FSQAMEVETGKPRPRYDTRTIVW---ICLTLITGLVVLLLLL----------------ICKKR-- 566
            .:.::.:....|.|..:...::.   :..||....:|.|.||                :.|.|  
  Fly   575 SNSSVYLRVVSPLPPLEIYALLHAHPLGFTLAAITIVALFLLGSAFITFMLRRLRREKLLKLRIE 639

Human   567 --HCGYSKA--FQDSDEEKMHYQNGQAPPPVF--------LPLHHPPGKLPEPQFYAEPHTYEEP 619
              |....|.  ::...||.....:|....||.        :......|..|...|    :.||.|
  Fly   640 TVHQWTKKVIIYRPGGEEGSGCSSGDLQMPVIRIEKQRTTVSTTGTGGTDPAQGF----NEYEFP 700

Human   620 GRAGRSFTREIEASRIHIEKIIGSGDSGEV----CYGRLRVPGQRDVPVAIKALKAGYTERQRRD 680
                .....||...::.:..|:|.|..|.|    ..|..|.|...:..||:|.:|..:|:.....
  Fly   701 ----LDSNWEIPRQQLSLGSILGEGAFGRVVMAEAEGLPRSPQLAETIVAVKMVKEEHTDTDMAS 761

Human   681 FLSEASIMGQF-DHPNIIRLEGVVTRGRLAMIVTEYMENGSLDTFLRTH-----------DGQFT 733
            .:.|..:|... .|.|||.|.|..::|....::.||..:|:|..||:.:           ||...
  Fly   762 LVREMEVMKMIGKHINIINLLGCCSQGGPLWVIVEYAPHGNLKDFLKQNRPGAPQRRSDSDGYLD 826

Human   734 IMQLVGMLR-----------GVGAGMRYLSDLGYVHRDLAARNVLVDSNLVCKVSDFGLSRVLED 787
            ...|:....           .:..||.||:....:|||||||||||....|.|::||||:|   |
  Fly   827 DKPLISTQHLGEKELTKFAFQIARGMEYLASRRCIHRDLAARNVLVSDGYVMKIADFGLAR---D 888

Human   788 DPDAAY--TTTGGKIPIRWTAPEAIAFRTFSSASDVWSFGVVMWEVLAYGERPYWN-MTNRDVIS 849
            ..|..|  ..|.|::||:|.|||::..:.:.|.|||||:||::||::.||::||.: ::..::.|
  Fly   889 IQDTEYYRKNTNGRLPIKWMAPESLQEKKYDSQSDVWSYGVLLWEIMTYGDQPYPHILSAEELYS 953

Human   850 SVEEGYRLPAPMGCPHALHQLMLDCWHKDRAQRPRFSQIVSVLDALIRSPES 901
            .:..|.|:..|..|...::.:|..|||.:...||.|:::|...|.:::...|
  Fly   954 YLITGQRMEKPAKCSLNIYVVMRQCWHFESCARPTFAELVESFDGILQQASS 1005

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EPHA8NP_065387.1 EphR_LBD 31..203 CDD:470656
FN3 <326..>519 CDD:442628 41/237 (17%)
fn3 439..524 CDD:394996 21/113 (19%)
EphA2_TM <562..632 CDD:464211 17/83 (20%)
Mediates interaction with ANKS1A and ANKS1B. /evidence=ECO:0000250 564..570 3/9 (33%)
Mediates interaction with PIK3CG and required for endocytosis. /evidence=ECO:0000250 589..644 12/62 (19%)
PTKc_EphR_A 630..896 CDD:270651 93/295 (32%)
SAM_EPH-A8 933..995 CDD:188949
PDZ-binding. /evidence=ECO:0000255 1003..1005
btlNP_729956.1 Ig 143..215 CDD:472250
Ig strand B 160..164 CDD:409570
Ig strand C 175..179 CDD:409570
Ig strand E 197..201 CDD:409570
Ig strand F 211..215 CDD:409570
Ig_3 247..333 CDD:464046 2/3 (67%)
Ig 398..479 CDD:472250 19/110 (17%)
Ig strand B 412..416 CDD:409393 2/5 (40%)
Ig strand C 423..427 CDD:409393 2/3 (67%)
Ig strand E 445..449 CDD:409393 2/3 (67%)
Ig strand F 459..464 CDD:409393 1/6 (17%)
Ig strand G 472..475 CDD:409393 0/2 (0%)
IG_like 492..583 CDD:214653 18/112 (16%)
Ig strand B 503..507 CDD:409444 1/25 (4%)
Ig strand C 516..520 CDD:409444 0/3 (0%)
Ig strand E 549..553 CDD:409444 1/3 (33%)
Ig strand F 563..568 CDD:409444 0/4 (0%)
Ig strand G 576..579 CDD:409444 0/2 (0%)
Protein Kinases, catalytic domain 700..1000 CDD:473864 95/306 (31%)
Blue background indicates that the domain is not in the aligned region.

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