DRSC/TRiP Functional Genomics Resources

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Protein Alignment EPHA8 and dnt

DIOPT Version :10

Sequence 1:NP_065387.1 Gene:EPHA8 / 2046 HGNCID:3391 Length:1005 Species:Homo sapiens
Sequence 2:NP_477341.2 Gene:dnt / 35207 FlyBaseID:FBgn0024245 Length:584 Species:Drosophila melanogaster


Alignment Length:627 Identity:155/627 - (24%)
Similarity:235/627 - (37%) Gaps:151/627 - (24%)


- Green bases have known domain annotations that are detailed below.


Human   356 GRSDITYNAVCR--RCPWALSRCEACGSGTRFVPQQTSLVQASLLV---ANLLAHMN-YSFWIEA 414
            |:|..|.|...:  |..|.||                .|..|:|.:   :.:.||:| :...:|.
  Fly     8 GKSASTRNCTVKMSRKMWVLS----------------LLALAALQLHSGSEVAAHLNVFLNPVEV 56

Human   415 VN--GVSDLSPEPRRAAVVNITTNQAAPSQVVVIRQERAGQTSVSLLWQEPEQPNGIILEYEIKY 477
            :.  |||......|...:.|...|...|..        |....:|..||...   |..|.|.|..
  Fly    57 MRLLGVSAEVYYVREGHINNYALNFIVPVP--------ANVKDISFTWQSLA---GRGLPYSINV 110

Human   478 YEKDKE------------------MQSYST------LKAVTTRATVS-------GLKPGTRYVFQ 511
            ...|:|                  :|::|.      |||.....|||       .|...|..|| 
  Fly   111 VSSDQEVLPRPAINVSHSGEIPTTIQTWSIALKCSGLKAAEVDVTVSLEVVLNRSLNNVTHLVF- 174

Human   512 VRARTSAGCGRFSQAMEVETGKPRPRYDTRTIVWI---CLTLITGLVV-------LLLLLICKKR 566
               |....|.....|.::......|:. ..|::..   .:||:.|:.|       ||::..|.| 
  Fly   175 ---RRKKICLMNDSAEDLSEDVDDPQL-LETVMLPPTGLITLVVGVSVAMGSVCLLLMIAYCVK- 234

Human   567 HCGYSKAFQDSDEEKMHYQNGQAP--------------------------PPVFLPLHHP--PGK 603
                     .:..::.|:|:|..|                          |.:..|:|..  |.|
  Fly   235 ---------GAANKRQHHQHGGQPMRTSSFQRLNTHPPCQSSMGSAAYMTPSIIAPIHGSSLPRK 290

Human   604 LP---EPQFYAEPHTYEEPGRAGRSFTREIEASRIHIEKIIGSGDSGEVCYGRLRVPGQRDVPVA 665
            :|   |.|...|.|.        |.....:|..|:.:..::..|..|.|..|...  ..:|  |.
  Fly   291 VPVSVEQQHPEELHR--------RISELTVERCRVRLSSLLQEGTFGRVYRGTYN--DTQD--VL 343

Human   666 IKALKAGYTERQRRDFLSEASIMGQFDHPNIIRLEGVVTRGRLAMIVTEYMENG--SLDTFL--- 725
            :|.:....::.|....|.|..::....||.|:.:.||.........|.....|.  :|..||   
  Fly   344 VKTVAQHASQMQVLLLLQEGMLLYGASHPGILSVLGVSIEDHTTPFVLYPALNNTRNLKQFLLDP 408

Human   726 ---RTHDGQFTIMQLVGMLRGVGAGMRYLSDLGYVHRDLAARNVLVDSNLVCKVSDFGLSRVLED 787
               ||    .|.:|:|.|...:...:.:|...|.||:|:|.||.::|..|..|:||..|||   |
  Fly   409 ACART----VTTIQIVMMASQLSMALDHLHSHGVVHKDIATRNCVIDDQLRVKLSDSSLSR---D 466

Human   788 DPDAAYTTTGG--KIPIRWTAPEAIAFRTFSSASDVWSFGVVMWEVLAYGERPYWNMTNRDVISS 850
            ...:.|...|.  ..|::|.:.||:..:.||.|||.|:|||:|||:....::||..:...::...
  Fly   467 LFPSDYNCLGDSENRPVKWMSLEALQHKQFSEASDSWAFGVLMWELCTSAKQPYAEVDPFEMEHY 531

Human   851 VEEGYRLPAPMGCPHALHQLMLDCWHKDRAQRPRFSQIVSVL 892
            :::||||..|..||..|..:|..||....|:||.|:|:.|.|
  Fly   532 LKDGYRLAQPFNCPDELFTIMAYCWALLPAERPTFAQLQSCL 573

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EPHA8NP_065387.1 EphR_LBD 31..203 CDD:470656
FN3 <326..>519 CDD:442628 45/201 (22%)
fn3 439..524 CDD:394996 25/115 (22%)
EphA2_TM <562..632 CDD:464211 17/100 (17%)
Mediates interaction with ANKS1A and ANKS1B. /evidence=ECO:0000250 564..570 1/5 (20%)
Mediates interaction with PIK3CG and required for endocytosis. /evidence=ECO:0000250 589..644 14/85 (16%)
PTKc_EphR_A 630..896 CDD:270651 83/273 (30%)
SAM_EPH-A8 933..995 CDD:188949
PDZ-binding. /evidence=ECO:0000255 1003..1005
dntNP_477341.2 WIF 46..182 CDD:128745 34/150 (23%)
Protein Kinases, catalytic domain 310..580 CDD:473864 83/275 (30%)
Blue background indicates that the domain is not in the aligned region.

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