Protein Alignment EPHA8 and Ror

DIOPT Version :10

• Sequence 1: NP_065387.1
• Gene: EPHA8 / 2046
• HGNCID: 3391
• Length: 1005
• Species: Homo sapiens
• Sequence 2: NP_476962.1
• Gene: Ror / 34367
• FlyBaseID: FBgn0010407
• Length: 685
• Species: Drosophila melanogaster
• Alignment Length: 384
• Identity: 120/384 - (31%)
• Similarity: 190/384 - (49%)
• Gaps: 70/384 - (18%)

Human   544 VWICLTLITGLVVLLLLLI-----CKKRHCGYSKAFQDSDEEKMHY--QNGQAPPPVFLPLHHPP 601
            :||.:...|..::|:.::|     .|:|..             |||  :|          :|:..
  Fly   314 IWIAIVGTTAAIILIFIIIFAIILFKRRTI-------------MHYGMRN----------IHNIN 355

Human   602 GKLPEPQFY--AEPHTYEEPGRAG-----------------------RSFT-REIEASRIHIEKI 640
            ....:...|  ::.:..::.||..                       ..|| :::|    .:|:
  Fly   356 TPSADKNIYGNSQLNNAQDAGRGNLGNLSDHVALNSKLIERNTLLRINHFTLQDVE----FLEE- 415

Human   641 IGSGDSGEVCYGRLRVPGQRDVPVAIKALKAGYTERQRRDFLSEASIMGQFDHPNIIRLEGVVTR 705
            :|.|..|:|..|:|..|.:..:.|||||||...:.:.::||..|..::....|.||:.:.|||..
  Fly   416 LGEGAFGKVYKGQLLQPNKTTITVAIKALKENASVKTQQDFKREIELISDLKHQNIVCILGVVLN 480

Human   706 GRLAMIVTEYMENGSLDTFL----RTHDGQFTIMQLVGMLRGVGAGMRYLSDLGYVHRDLAARNV 766
            .....::.|||.||.|..||    .|.....:.::.:.:...:..||:|||...||||||||||.
  Fly   481 KEPYCMLFEYMANGDLHEFLISNSPTEGKSLSQLEFLQIALQISEGMQYLSAHHYVHRDLAARNC 545

Human   767 LVDSNLVCKVSDFGLSRVLEDDPDAAYTTTGGK--IPIRWTAPEAIAFRTFSSASDVWSFGVVMW 829
            ||:..||.|:|||||||   |...:.|.....|  :|:||...|:|.:..|::.|||||||||:|
  Fly   546 LVNEGLVVKISDFGLSR---DIYSSDYYRVQSKSLLPVRWMPSESILYGKFTTESDVWSFGVVLW 607

Human   830 EVLAYGERPYWNMTNRDVISSVEEGYRLPAPMGCPHALHQLMLDCWHKDRAQRPRFSQI 888
            |:.:||.:||:..:|::||:.:.....|.||..||.|::.||::|||:...:||.|:.|
  Fly   608 EIYSYGMQPYYGFSNQEVINLIRSRQLLSAPENCPTAVYSLMIECWHEQSVKRPTFTDI 666

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EPHA8	NP_065387.1	EphR_LBD	31..203	CDD:470656
		FN3	<326..>519	CDD:442628
		fn3	439..524	CDD:394996
		EphA2_TM	<562..632	CDD:464211	13/102 (13%)
		Mediates interaction with ANKS1A and ANKS1B. /evidence=ECO:0000250	564..570		2/5 (40%)
		Mediates interaction with PIK3CG and required for endocytosis. /evidence=ECO:0000250	589..644		9/80 (11%)
		PTKc_EphR_A	630..896	CDD:270651	103/265 (39%)
		SAM_EPH-A8	933..995	CDD:188949
		PDZ-binding. /evidence=ECO:0000255	1003..1005
Ror	NP_476962.1	CRD_TK_ROR_like	39..228	CDD:143568
		KR	235..312	CDD:214527
		PTKc_Ror	404..673	CDD:270642	105/271 (39%)