DRSC/TRiP Functional Genomics Resources

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Protein Alignment EPHA8 and Ddr

DIOPT Version :10

Sequence 1:NP_065387.1 Gene:EPHA8 / 2046 HGNCID:3391 Length:1005 Species:Homo sapiens
Sequence 2:NP_001014474.3 Gene:Ddr / 3346209 FlyBaseID:FBgn0053531 Length:1054 Species:Drosophila melanogaster


Alignment Length:582 Identity:136/582 - (23%)
Similarity:212/582 - (36%) Gaps:219/582 - (37%)


- Green bases have known domain annotations that are detailed below.


Human   511 QVRARTSAGCGRFSQAMEVETGKPRPRYDTRT-----IVWICLTLITGLVVLLLLLICKKRHCGY 570
            :|....|:|..|.....:|.:.||....:..|     |:.:..|:|..||..:||::.:.:|...
  Fly   468 EVGRAISSGGERSQHTTQVISPKPIDHQEPETSFVGVIITVLGTIIMLLVAFILLIVARNKHVRS 532

Human   571 SK----AFQ--------------------DSDEEKM----------------------------- 582
            .:    |||                    |.:|..:                             
  Fly   533 RENGLDAFQHNFSPDTLNGNGVLKVVTTMDDNESSIDKNSLYHEPFNANMYTSAASACPMNDLQR 597

Human   583 ---------------------HYQN--GQAPP------------------PVF------------ 594
                                 |.|.  ..|||                  |.|            
  Fly   598 QHVSPDYTDVPDIVCQDYAVPHMQQLLPNAPPCGSGCGTGTGTGPGRGSSPEFVVATGKVTASAR 662

Human   595 -------LPLHHPPGKLPEPQFYA----------------------------------------E 612
                   |||..||...|..::||                                        :
  Fly   663 NSLNAATLPLPSPPVPPPLEKYYAATPVSSKPMPVAPPGSQSSGSLSSSTTAATTPTSGVVGVGK 727

Human   613 PHTY------------EEPGRAG---RSFTREIEASRIHIEKIIGSGDSGEVCYGRLRVPGQRDV 662
            ||.|            ||  ||.   :.|.|:   |.:.:|| :|||..||:......|  ....
  Fly   728 PHHYNLDMSANFADINEE--RANCQVQEFPRQ---SLVIVEK-LGSGVFGELHLCETNV--LNAT 784

Human   663 PVAIKALKAGYTERQRRDFLSEASIMGQFDHPNIIRLEGVVTRGRLAMIVTEYME-NGSLDTFLR 726
            .||:..|:.|..:..|::|.|:|..:.|...||:.||.|...|.....||.:|.. .|.|:.||:
  Fly   785 LVAVATLRPGANDHLRKEFRSKAKQLAQLSDPNVARLVGACLRDEPICIVQDYSHCLGDLNQFLQ 849

Human   727 THDGQFTIMQ---------LVGMLRGVGAGMRYLSDLGYVHRDLAARNVLVDSNLVCKVSDFG-- 780
            .|..:.:.:.         ||.:...:.:||::|..:.:||||||.|:.::...|..||...|  
  Fly   850 EHVAETSGLMAKKSLSFGCLVYIATQIASGMKHLEQMNFVHRDLATRSCIIGPELCVKVCSIGTV 914

Human   781 LSRVLEDDPDAAYTT--------TGGK---IPIRWTAPEAIAFRTFSSASDVWSFGVVMWEVLAY 834
            ::|       :||.:        ||.:   :||||.|.|::....|::.||||||.|.:||:|.:
  Fly   915 INR-------SAYASDYCQLEGFTGRQSQPMPIRWMAWESVLLGKFTTKSDVWSFAVALWEILTF 972

Human   835 G-ERPYWNMTNRDVISSVEEGYR-------LPAPMGCPHALHQLMLDCWHKDRAQRPRFSQI 888
            . |:||.:::::.||.::...||       ||.|..||..::.||.:||.:|.:.||.|.:|
  Fly   973 AREQPYEHLSDKSVIENIGLIYRDYKMHELLPMPPNCPREIYDLMCECWQRDESSRPSFREI 1034

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EPHA8NP_065387.1 EphR_LBD 31..203 CDD:470656
FN3 <326..>519 CDD:442628 2/7 (29%)
fn3 439..524 CDD:394996 4/12 (33%)
EphA2_TM <562..632 CDD:464211 30/237 (13%)
Mediates interaction with ANKS1A and ANKS1B. /evidence=ECO:0000250 564..570 1/5 (20%)
Mediates interaction with PIK3CG and required for endocytosis. /evidence=ECO:0000250 589..644 26/146 (18%)
PTKc_EphR_A 630..896 CDD:270651 91/290 (31%)
SAM_EPH-A8 933..995 CDD:188949
PDZ-binding. /evidence=ECO:0000255 1003..1005
DdrNP_001014474.3 FA58C 109..261 CDD:238014
PTKc_DDR 753..1040 CDD:270644 93/295 (32%)
Blue background indicates that the domain is not in the aligned region.

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