DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment EPHA8 and Epha8

DIOPT Version :9

Sequence 1:	NP_065387.1	Gene:	EPHA8 / 2046	HGNCID:	3391	Length:	1005	Species:	Homo sapiens
Sequence 2:	NP_031965.2	Gene:	Epha8 / 13842	MGIID:	109378	Length:	1004	Species:	Mus musculus

Alignment Length:	1005	Identity:	957/1005 - (95%)
Similarity:	977/1005 - (97%)	Gaps:	1/1005 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MAPARGRLPPALWVVTAAAAAATCVSAARGEVNLLDTSTIHGDWGWLTYPAHGWDSINEVDESFQ 65
            |||||.||.||||||| ||||||||||.||||||||||||||||||||||||||||||||||||:
Mouse     1 MAPARARLSPALWVVT-AAAAATCVSAGRGEVNLLDTSTIHGDWGWLTYPAHGWDSINEVDESFR 64

Human    66 PIHTYQVCNVMSPNQNNWLRTSWVPRDGARRVYAEIKFTLRDCNSMPGVLGTCKETFNLYYLESD 130
            |||||||||||||||||||||:|||||||||||||||||||||||:|||||||||||||:|||||
Mouse    65 PIHTYQVCNVMSPNQNNWLRTNWVPRDGARRVYAEIKFTLRDCNSIPGVLGTCKETFNLHYLESD 129

Human   131 RDLGASTQESQFLKIDTIAADESFTGADLGVRRLKLNTEVRSVGPLSKRGFYLAFQDIGACLAIL 195
            |||||||||||||||||||||||||||||||||||||||||.|||||||||||||||||||||||
Mouse   130 RDLGASTQESQFLKIDTIAADESFTGADLGVRRLKLNTEVRGVGPLSKRGFYLAFQDIGACLAIL 194

Human   196 SLRIYYKKCPAMVRNLAAFSEAVTGADSSSLVEVRGQCVRHSEERDTPKMYCSAEGEWLVPIGKC 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   195 SLRIYYKKCPAMVRNLAAFSEAVTGADSSSLVEVRGQCVRHSEERDTPKMYCSAEGEWLVPIGKC 259

Human   261 VCSAGYEERRDACVACELGFYKSAPGDQLCARCPPHSHSAAPAAQACHCDLSYYRAALDPPSSAC 325
            |||||||||||||:||||||||||||||||||||||||||.||||.|.||||||||||||||:||
Mouse   260 VCSAGYEERRDACMACELGFYKSAPGDQLCARCPPHSHSATPAAQTCRCDLSYYRAALDPPSAAC 324

Human   326 TRPPSAPVNLISSVNGTSVTLEWAPPLDPGGRSDITYNAVCRRCPWALSRCEACGSGTRFVPQQT 390
            |||||||||||||||||||||||||||||||||||||||||||||||||.|||||||||||||||
Mouse   325 TRPPSAPVNLISSVNGTSVTLEWAPPLDPGGRSDITYNAVCRRCPWALSHCEACGSGTRFVPQQT 389

Human   391 SLVQASLLVANLLAHMNYSFWIEAVNGVSDLSPEPRRAAVVNITTNQAAPSQVVVIRQERAGQTS 455
            ||.||||||||||||||||||||||||||:||||||.||||||||||||||||||||||||||||
Mouse   390 SLAQASLLVANLLAHMNYSFWIEAVNGVSNLSPEPRSAAVVNITTNQAAPSQVVVIRQERAGQTS 454

Human   456 VSLLWQEPEQPNGIILEYEIKYYEKDKEMQSYSTLKAVTTRATVSGLKPGTRYVFQVRARTSAGC 520
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   455 VSLLWQEPEQPNGIILEYEIKYYEKDKEMQSYSTLKAVTTRATVSGLKPGTRYVFQVRARTSAGC 519

Human   521 GRFSQAMEVETGKPRPRYDTRTIVWICLTLITGLVVLLLLLICKKRHCGYSKAFQDSDEEKMHYQ 585
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   520 GRFSQAMEVETGKPRPRYDTRTIVWICLTLITGLVVLLLLLICKKRHCGYSKAFQDSDEEKMHYQ 584

Human   586 NGQAPPPVFLPLHHPPGKLPEPQFYAEPHTYEEPGRAGRSFTREIEASRIHIEKIIGSGDSGEVC 650
            ||||||||||||:|||||.||.||.||||||||||||||||||||||||||||||||||:|||||
Mouse   585 NGQAPPPVFLPLNHPPGKFPETQFSAEPHTYEEPGRAGRSFTREIEASRIHIEKIIGSGESGEVC 649

Human   651 YGRLRVPGQRDVPVAIKALKAGYTERQRRDFLSEASIMGQFDHPNIIRLEGVVTRGRLAMIVTEY 715
            ||||:|||||||||||||||||||||||:||||||:|||||||||||||||||||||||||||||
Mouse   650 YGRLQVPGQRDVPVAIKALKAGYTERQRQDFLSEAAIMGQFDHPNIIRLEGVVTRGRLAMIVTEY 714

Human   716 MENGSLDTFLRTHDGQFTIMQLVGMLRGVGAGMRYLSDLGYVHRDLAARNVLVDSNLVCKVSDFG 780
            |||||||.|||||||||||:|||||||||||||||||||||:||||||||||||..|||||||||
Mouse   715 MENGSLDAFLRTHDGQFTIVQLVGMLRGVGAGMRYLSDLGYIHRDLAARNVLVDGRLVCKVSDFG 779

Human   781 LSRVLEDDPDAAYTTTGGKIPIRWTAPEAIAFRTFSSASDVWSFGVVMWEVLAYGERPYWNMTNR 845
            |||.|||||:|||||.||||||||||||||||||||||||||||||||||||||||||||||||:
Mouse   780 LSRALEDDPEAAYTTAGGKIPIRWTAPEAIAFRTFSSASDVWSFGVVMWEVLAYGERPYWNMTNQ 844

Human   846 DVISSVEEGYRLPAPMGCPHALHQLMLDCWHKDRAQRPRFSQIVSVLDALIRSPESLRATATVSR 910
            |||||||||||||||||||.||||||||||||||||||||:.:|||||||:.|||||||||||||
Mouse   845 DVISSVEEGYRLPAPMGCPRALHQLMLDCWHKDRAQRPRFAHVVSVLDALVHSPESLRATATVSR 909

Human   911 CPPPAFVRSCFDLRGGSGGGGGLTVGDWLDSIRMGRYRDHFAAGGYSSLGMVLRMNAQDVRALGI 975
            ||||||.|||||||.|..|.|.|||||||||||||||||||||||||||||||||||||||||||
Mouse   910 CPPPAFARSCFDLRAGGSGNGDLTVGDWLDSIRMGRYRDHFAAGGYSSLGMVLRMNAQDVRALGI 974

Human   976 TLMGHQKKILGSIQTMRAQLTSTQGPRRHL 1005
            ||||||||||||||||||||:|||||||||
Mouse   975 TLMGHQKKILGSIQTMRAQLSSTQGPRRHL 1004

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EPHA8	NP_065387.1	EphR_LBD	31..203	CDD:295439	166/171 (97%)
		fn3	330..423	CDD:278470	89/92 (97%)
		FN3	440..531	CDD:238020	90/90 (100%)
		Mediates interaction with ANKS1A and ANKS1B. /evidence=ECO:0000250	564..570		5/5 (100%)
		EphA2_TM	<566..630	CDD:291255	59/63 (94%)
		Mediates interaction with PIK3CG and required for endocytosis. /evidence=ECO:0000250	589..644		50/54 (93%)
		PTKc_EphR_A	630..896	CDD:270651	248/265 (94%)
		Pkinase_Tyr	635..892	CDD:285015	239/256 (93%)
		SAM_EPH-A8	933..995	CDD:188949	61/61 (100%)
		SAM	934..994	CDD:197735	59/59 (100%)
		PDZ-binding. /evidence=ECO:0000255	1003..1005		1/1 (100%)
Epha8	NP_031965.2	EphR_LBD_A8	30..202	CDD:198454	166/171 (97%)
		fn3	329..422	CDD:278470	89/92 (97%)
		FN3	439..530	CDD:238020	90/90 (100%)
		Mediates interaction with ANKS1A and ANKS1B. /evidence=ECO:0000269\|PubMed:17875921	563..569		5/5 (100%)
		EphA2_TM	<565..629	CDD:291255	59/63 (94%)
		Mediates interaction with PIK3CG and required for endocytosis. /evidence=ECO:0000269\|PubMed:11416136	588..643		50/54 (93%)
		PKc_like	629..895	CDD:304357	248/265 (94%)
		Pkinase_Tyr	634..891	CDD:285015	239/256 (93%)
		SAM_EPH-A8	932..994	CDD:188949	61/61 (100%)
		SAM	933..993	CDD:197735	59/59 (100%)
		PDZ-binding. /evidence=ECO:0000255	1002..1004		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83971926
Domainoid	1	1.000	501	1.000	Domainoid score	I7671
eggNOG	1	0.900	-	-		E2759_KOG0196
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H22436
Inparanoid	1	1.050	1965	1.000	Inparanoid score	I1681
Isobase	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG45908
OrthoDB	1	1.010	-	-		D29780at32523
OrthoFinder	1	1.000	-	-		FOG0000086
OrthoInspector	1	1.000	-	-		oto128096
orthoMCL	1	0.900	-	-		OOG6_100189
Panther	1	1.100	-	-	LDO	PTHR24416
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8268
SonicParanoid	1	1.000	-	-		X82
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	18	18.300