DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment EPHA5 and Eph

DIOPT Version :9

Sequence 1:	NP_001268694.1	Gene:	EPHA5 / 2044	HGNCID:	3389	Length:	1038	Species:	Homo sapiens
Sequence 2:	NP_524625.3	Gene:	Eph / 43803	FlyBaseID:	FBgn0025936	Length:	1096	Species:	Drosophila melanogaster

Alignment Length:	1087	Identity:	435/1087 - (40%)
Similarity:	608/1087 - (55%)	Gaps:	150/1087 - (13%)

- Green bases have known domain annotations that are detailed below.

Human    36 RRAPLWTCLLLCAALRTLLASPSNEVNLLDSRTVMGDLGWIAFPKN------GWEEIGEVDENYA 94
            |.:.|.|.||:..::...||. :::|.|||: |....|.|..:|..      ||     |:|::.
  Fly    61 RMSLLRTILLIIISIHFKLAH-ADQVVLLDT-TREATLEWTRYPYGPQAQTPGW-----VEESFT 118

Human    95 PI------HTYQVCKVMEQNQNNWLLTSWISNEGASRIFIELKFTLRDCNSLPGGLGTCKETFNM 153
            ..      .:|.||.|...|.||||.:.:|....|:|::||::||:|||:..||...:|||||::
  Fly   119 DFVKGINWRSYVVCDVAYHNVNNWLWSPFIDRGSANRLYIEIQFTIRDCSLFPGNALSCKETFSL 183

Human   154 YYFESD--DQNGRNIKENQYIKIDTIAADES-FTELDLGDRVMKLNTEVRDVGPLSKKGFYLAFQ 215
            .::|.|  .:.....:.:.|..|..|||.|. |.:    :..:.:||||:.:. ::|||.|.||:
  Fly   184 LFYEFDAATREPPPWQTDSYRLIARIAAGEGRFNQ----NSDVDINTEVKSIA-VNKKGVYFAFR 243

Human   216 DVGACIALVSVRVYYKKCPSVVRHLAVFPDTITGADSSQLLEVSGSCVNHSVTDEPPKMHCSAEG 280
            |.||||::::|:|||..||:|..:.|.|.:|.||.:.:.:.:.:|:||:::...|.|...|..:|
  Fly   244 DQGACISVLAVKVYYITCPAVTENFAHFNETPTGREITIIEKQNGTCVDNAEPYETPTYLCKGDG 308

Human   281 EWLVPIGKCMCKAGYEEK--NGTCQVCRPGFFKASPHIQSCGKCPPHSYTHEEASTSCVCEKDYF 343
            :|.:..|.|.||||||..  |.||..|..|.|| ||.:..|..|||:|...:..|..|.|...::
  Fly   309 KWTILTGGCRCKAGYEPNYTNKTCTECPLGTFK-SPEVTKCTPCPPNSNASKTGSPFCKCASGFY 372

Human   344 RRESDPPTMACTRPPSAPRN-AISNVNETSVFLEWIPPA-------DTGGR---KDVSYYIACKK 397
            |..:|...|.|..||:||.| .:..|::||..:.|..||       :|..:   .|:.|.|   |
  Fly   373 RHPNDGRHMPCYSPPAAPTNLTLLFVDQTSAIISWSAPAKNESFSSETNSKIYHSDIVYKI---K 434

Human   398 CNSHAGVCEECGGHVRYLPRQSGLKNTSVMMVDLLAHTNYTFEIEAVNGVS-------------- 448
            ||.       |..:|.|.|.......|.:.:.:|...|.||.:|.|:|.||
  Fly   435 CNI-------CSPNVVYNPSTDTFNETKITLTNLEPVTTYTVQIHAINSVSHINEFKRHSNESSL 492

Human   449 ------------------DLSPGARQYVSVNVTTNQAAPSPVTNVKKGKIAKNSISLSWQEPDRP 495
                              ||:........:..||.....|.|.|::...|......|.|.:|.:.
  Fly   493 VAVSDIVFSNTSLLNIPLDLNEVKTGQAEIVFTTESVLLSTVFNLRILAITNKDADLEWDKPVQS 557

Human   496 NGIILEYEIKYFEKDQ--ETSYTIIKSKETTITAEGLKPASVYVFQIRARTAAGYGVFSRRFEFE 558
            :..:..||:::|.|.:  ..:.:.:.:|||.....||...:.|.||:|.:|..|:|.:|.....:
  Fly   558 DFPLEFYEVRWFPKVELDAINKSALNTKETKAHIVGLLENTEYGFQVRCKTNNGFGSYSNMIYAQ 622

Human   559 TTPVSVAASSDQSQIPVIAVSVTVGVILLAVVIGVLLSGSCCECGCGRASSLCAVAHPSLIWRCG 623
            |.....:...|..||..||.::..||:.|.:.|                           |....
  Fly   623 TLQSVGSVYDDSVQIRFIAGAIVTGVLFLVIFI---------------------------IATVY 660

Human   624 YSKAK-QDPEEEKMHFHNGHIKLP------------------------------GVRTYIDPHTY 657
            :.::| ||..::|   ...|:.||                              ..|:|:|||||
  Fly   661 FMRSKHQDDLDKK---STNHLPLPLDYASNEVNSMDTTPIVKKLHLNVTTPLFGNSRSYVDPHTY 722

Human   658 EDPNQAVHEFAKEIEASCITIERVIGAGEFGEVCSGRLKLPGK--RELPVAIKTLKVGYTEKQRR 720
            ||||||:.|||:||:|:.||||.:||.||||:||.||||:|..  :::.|||||||.|.:||.|.
  Fly   723 EDPNQAIREFAREIDANYITIEAIIGGGEFGDVCRGRLKIPPNFVQDIDVAIKTLKPGSSEKARC 787

Human   721 DFLGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGI 785
            |||.||||||||||||:|:|:||||:|.||||:|||||||||||||:.|||:|..:||:.|||||
  Fly   788 DFLTEASIMGQFDHPNVIYLQGVVTRSNPVMIITEYMENGSLDTFLRVNDGKFQTLQLIVMLRGI 852

Human   786 SAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEA 850
            ::||.|||||.||||||||||:|:|:.|:||::||||||.:|:..: ||||||||||:|||||||
  Fly   853 ASGMSYLSDMNYVHRDLAARNVLVNAQLICKIADFGLSREIENASD-AYTTRGGKIPVRWTAPEA 916

Human   851 IAFRKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEGYRLPSPMDCPAALYQLMLDC 915
            ||||||||||||||||:|:|||:||||||||..:||||||::|:|||||:|||||.|||||||||
  Fly   917 IAFRKFTSASDVWSYGVVLWEVMSYGERPYWNWSNQDVIKSIEKGYRLPAPMDCPEALYQLMLDC 981

Human   916 WQKERNSRPKFDEIVNMLDKLIRNPSSLKTLVNASCRVSNLLAEHSPLGSGAYRSVGEWLEAIKM 980
            |||:|..||.|..||:.||.|.|.|.||.|...:.....|.:.: ...|...:.|...|||.|||
  Fly   982 WQKQRTHRPTFASIVSTLDNLARQPQSLLTTRPSPESDGNHILD-GQRGQNIFISTDLWLEHIKM 1045

Human   981 GRYTEIFMENGYSSMDAVAQVTLEDLRRLGVTLVGHQKKIMNSLQEM 1027
            .||...|.|....:...::::|.:.|..:|:|||||||||::..:::
  Fly  1046 SRYCHHFKEANLINAQQISRLTAQQLSDMGITLVGHQKKILHQARQL 1092

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EPHA5	NP_001268694.1	EphR_LBD_A5	60..232	CDD:198451	66/186 (35%)
		FN3	358..464	CDD:238020	33/148 (22%)
		FN3	469..559	CDD:238020	24/91 (26%)
		EphA2_TM	579..671	CDD:291255	28/122 (23%)
		PTKc_EphR_A	671..937	CDD:270651	191/267 (72%)
		Pkinase_Tyr	676..933	CDD:285015	187/258 (72%)
		SAM_EPH-A5	966..1031	CDD:188945	23/62 (37%)
		SAM	970..1028	CDD:197735	23/58 (40%)
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439	66/185 (36%)
		FN3	387..476	CDD:238020	28/98 (29%)
		FN3	536..623	CDD:238020	22/86 (26%)
		EphA2_TM	644..736	CDD:291255	28/121 (23%)
		PTKc_EphR	736..1002	CDD:270629	191/266 (72%)
		Pkinase_Tyr	741..999	CDD:285015	187/258 (72%)
		SAM_1	1033..1092	CDD:278937	23/58 (40%)
		SAM	1039..1092	CDD:197735	22/52 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	399	1.000	Domainoid score	I741
eggNOG	1	0.900	-	-		E2759_KOG0196
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	762	1.000	Inparanoid score	I548
Isobase	1	0.950	-	0	Normalized mean entropy	S3200
OMA	1	1.010	-	-		QHG45908
OrthoDB	1	1.010	-	-		D397694at33208
OrthoFinder	1	1.000	-	-		FOG0000086
OrthoInspector	1	1.000	-	-		otm42229
orthoMCL	1	0.900	-	-		OOG6_100189
Panther	1	1.100	-	-	O	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X82
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.830