DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment EPHA4 and DUN1

DIOPT Version :9

Sequence 1:	NP_001291465.1	Gene:	EPHA4 / 2043	HGNCID:	3388	Length:	986	Species:	Homo sapiens
Sequence 2:	NP_010182.1	Gene:	DUN1 / 851457	SGDID:	S000002259	Length:	513	Species:	Saccharomyces cerevisiae

Alignment Length:	406	Identity:	88/406 - (21%)
Similarity:	167/406 - (41%)	Gaps:	114/406 - (28%)

- Green bases have known domain annotations that are detailed below.

Human   575 KYSKAKQ---EADEEKHLNQGVRTYV-DPFTYEDP------------NQAVREFAKEIDASCIK- 622
            ||:.:..   |.|:|| ::...|:|. |...::.|            :.|:|:..|....|...
Yeast   136 KYASSSSTDIENDDEK-VSSESRSYKNDDEVFKKPQISATSSQNATTSAAIRKLNKTRPVSFFDK 199

Human   623 --IEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRD--FLSEASIMGQFDHPNII 683
              :.|.:|.|.:..|...:.|..|::   ||:|...|...|.|:::  |..|.:|:.:..||||:
Yeast   200 YLLGKELGAGHYALVKEAKNKKTGQQ---VAVKIFHAQQNDDQKKNKQFREETNILMRVQHPNIV 261

Human   684 HLEGVVTKCKPV-------MIITEYMENGSL------DAFLRKNDGRFTVIQLVGMLRGIGSGMK 735
            :|  :.:..:|:       .::.|.:::|.|      ...||:::.:....||:       :|:|
Yeast   262 NL--LDSFVEPISKSQIQKYLVLEKIDDGELFERIVRKTCLRQDESKALFKQLL-------TGLK 317

Human   736 YLSDMSYVHRDLAARNILVN-------------------SNLVCKVSDFGMSRVLEDDPEAAYTT 781
            ||.:.:.:|||:...|||:|                   .::..|::|||:::.   ..|..:|.
Yeast   318 YLHEQNIIHRDIKPENILLNITRRENPSQVQLGPWDEDEIDIQVKIADFGLAKF---TGEMQFTN 379

Human   782 RGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVM-------------SYGER---------- 823
            .....| .:.|||.:..:.:||..|:||.|::::..:             |..|:
Yeast   380 TLCGTP-SYVAPEVLTKKGYTSKVDLWSAGVILYVCLCGFPPFSDQLGPPSLKEQILQAKYAFYS 443

Human   824 PYWDMSNQDVIKAI--------EEGYRLPPPMDCPIALHQLMLDCWQKERSDRPKFGQIVNMLDK 880
            ||||..:..|:..|        :|.|.:...::.|          |   .:|..:...:...|.:
Yeast   444 PYWDKIDDSVLHLISNLLVLNPDERYNIDEALNHP----------W---FNDIQQQSSVSLELQR 495

Human   881 LIRNPNSLKRTGTESS 896
            |....|.:.:|.:|.|
Yeast   496 LQITDNKIPKTYSELS 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EPHA4	NP_001291465.1	EphR_LBD_A4	30..203	CDD:198450
		FN3	329..436	CDD:238020
		FN3	441..532	CDD:238020
		EphA2_TM	562..618	CDD:405290	13/58 (22%)
		PTKc_EphR_A	616..882	CDD:270651	70/333 (21%)
		SAM_EPH-A4	911..981	CDD:188944
		PDZ-binding. /evidence=ECO:0000255	984..986
DUN1	NP_010182.1	FHA	36..136	CDD:238017	88/406 (22%)
DUN1	NP_010182.1	STKc_CAMK	199..479	CDD:270687	66/305 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910