| Sequence 1: | NP_001291465.1 | Gene: | EPHA4 / 2043 | HGNCID: | 3388 | Length: | 986 | Species: | Homo sapiens |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_524625.3 | Gene: | Eph / 43803 | FlyBaseID: | FBgn0025936 | Length: | 1096 | Species: | Drosophila melanogaster |
| Alignment Length: | 1053 | Identity: | 439/1053 - (41%) |
|---|---|---|---|
| Similarity: | 598/1053 - (56%) | Gaps: | 146/1053 - (13%) |
- Green bases have known domain annotations that are detailed below.
|
Human 28 ANEVTLLDSRSVQGELGWIASPL-----EGGWEEVSIMD-EKNTPIRTYQVCNVMEPSQNNWLRT 86
Human 87 DWITREGAQRVYIEIKFTLRDCNSLPGVMGTCKETFNLYYYESD----------NDKERFIRENQ 141
Human 142 FVKIDTIAADES-FTQ---VDIGDRIMKLNTEIRDVGPLSKKGFYLAFQDVGACIALVSVRVFYK 202
Human 203 KCPLTVRNLAQFPDTITGADTSSLVEVRGSCVNNSEEKDVPKMYCGADGEWLVPIGNCLCNAGHE 267
Human 268 ER--SGECQACKIGYYKALSTDAT-CAKCPPHSYSVWEGATSCTCDRGFFRADNDAASMPCTRPP 329
Human 330 SAPLNL-ISNVNETSVNLEWSSP-------QNTGGR---QDISYNVVCKKCGAGDPSKCRPCGSG 383
Human 384 VHYTPQQNGLKTTKVSITDLLAHTNYTFEIWAVNGVS-----KYNPNPDQSVSVT---------- 433
Human 434 -----------------VTTNQAAPSSIALVQAKEVTRYSVALAWLEPDRPNGVILEYEVKYYEK 481
Human 482 DQNERSYRIVRTAARNT-----DIKGLNPLTSYVFHVRARTAAGYGDFSEPLEVTTNTVPSRIIG 541
Human 542 DGANSTVLLVSVSGSVVLVVILIAAFVISRRRSKYSKAKQEADEEK------------------- 587
Human 588 --------HLN------QGVRTYVDPFTYEDPNQAVREFAKEIDASCIKIEKVIGVGEFGEVCSG 638
Human 639 RLKVPGK--REICVAIKTLKAGYTDKQRRDFLSEASIMGQFDHPNIIHLEGVVTKCKPVMIITEY 701
Human 702 MENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFG 766
Human 767 MSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQ 831
Human 832 DVIKAIEEGYRLPPPMDCPIALHQLMLDCWQKERSDRPKFGQIVNMLDKLIRNPNSLKRTGTESS 896
Human 897 RPNTALLDPSSPEFSAVVSVGDWLQAIKMDRYKDNFTAAGYTTLEAVVHVNQEDLARIGITAITH 961
Human 962 QNKILSSVQAMRT 974 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| EPHA4 | NP_001291465.1 | EphR_LBD_A4 | 30..203 | CDD:198450 | 75/192 (39%) |
| FN3 | 329..436 | CDD:238020 | 37/149 (25%) | ||
| FN3 | 441..532 | CDD:238020 | 24/95 (25%) | ||
| EphA2_TM | 562..618 | CDD:405290 | 27/88 (31%) | ||
| PTKc_EphR_A | 616..882 | CDD:270651 | 193/267 (72%) | ||
| SAM_EPH-A4 | 911..981 | CDD:188944 | 20/64 (31%) | ||
| PDZ-binding. /evidence=ECO:0000255 | 984..986 | ||||
| Eph | NP_524625.3 | EphR_LBD | 85..260 | CDD:198439 | 75/191 (39%) |
| FN3 | 387..476 | CDD:238020 | 30/99 (30%) | ||
| FN3 | 536..623 | CDD:238020 | 23/90 (26%) | ||
| EphA2_TM | 644..736 | CDD:291255 | 27/91 (30%) | ||
| PTKc_EphR | 736..1002 | CDD:270629 | 193/266 (73%) | ||
| Pkinase_Tyr | 741..999 | CDD:285015 | 188/258 (73%) | ||
| SAM_1 | 1033..1092 | CDD:278937 | 19/58 (33%) | ||
| SAM | 1039..1092 | CDD:197735 | 18/52 (35%) | ||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 1 | 1.000 | 399 | 1.000 | Domainoid score | I741 |
| eggNOG | 1 | 0.900 | - | - | E2759_KOG0196 | |
| Hieranoid | 1 | 1.000 | - | - | ||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 1 | 1.050 | 762 | 1.000 | Inparanoid score | I548 |
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 1 | 1.010 | - | - | QHG45908 | |
| OrthoDB | 1 | 1.010 | - | - | D397694at33208 | |
| OrthoFinder | 1 | 1.000 | - | - | FOG0000086 | |
| OrthoInspector | 1 | 1.000 | - | - | otm42229 | |
| orthoMCL | 1 | 0.900 | - | - | OOG6_100189 | |
| Panther | 1 | 1.100 | - | - | LDO | PTHR24416 |
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 1 | 1.030 | - | avgDist | Average_Evolutionary_Distance | R2895 |
| SonicParanoid | 1 | 1.000 | - | - | X82 | |
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 13 | 12.910 | |||||