DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment EPHA4 and epha4l

DIOPT Version :9

Sequence 1:	NP_001291465.1	Gene:	EPHA4 / 2043	HGNCID:	3388	Length:	986	Species:	Homo sapiens
Sequence 2:	XP_687698.2	Gene:	epha4l / 30687	ZFINID:	ZDB-GENE-990415-61	Length:	988	Species:	Danio rerio

Alignment Length:	989	Identity:	741/989 - (74%)
Similarity:	857/989 - (86%)	Gaps:	7/989 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MAGIFYFALFSCLFGICDAVTGSRVYPANEVTLLDSRSVQGELGWIASPLEGGWEEVSIMDEKNT 65
            ||||.| ||.|...|||..::..|..|||||||||||||||||.|:|||.||||||||||||||.
Zfish     4 MAGIIY-ALTSLFLGICAGLSAPRSPPANEVTLLDSRSVQGELAWVASPTEGGWEEVSIMDEKNI 67

Human    66 PIRTYQVCNVMEPSQNNWLRTDWITREGAQRVYIEIKFTLRDCNSLPGVMGTCKETFNLYYYESD 130
            |||||||||||||||||||||.||.|..|||:|||||||||||||||||:|||||||||||.|||
Zfish    68 PIRTYQVCNVMEPSQNNWLRTHWIQRGAAQRIYIEIKFTLRDCNSLPGVIGTCKETFNLYYLESD 132

Human   131 NDKERFIRENQFVKIDTIAADESFTQVDIGDRIMKLNTEIRDVGPLSKKGFYLAFQDVGACIALV 195
            :|.||:..|::|.||||:|||||||||||||||||||||:||||.||:.||||||||||||||||
Zfish   133 SDNERYAHESRFSKIDTVAADESFTQVDIGDRIMKLNTEVRDVGVLSRAGFYLAFQDVGACIALV 197

Human   196 SVRVFYKKCPLTVRNLAQFPDTITGADTSSLVEVRGSCVNNSEEKDVPKMYCGADGEWLVPIGNC 260
            ||.||||||||.||||||||||:||||||||||||||||::|||::|||||||||||||||||||
Zfish   198 SVHVFYKKCPLAVRNLAQFPDTVTGADTSSLVEVRGSCVDHSEEQEVPKMYCGADGEWLVPIGNC 262

Human   261 LCNAGHEERSGECQACKIGYYKALSTDATCAKCPPHSYSVWEGATSCTCDRGFFRADNDAASMPC 325
            |||.|:|||..:||.||:|||::||:|..|.|||.|||||.||||||.||:|::|::.|.|:|||
Zfish   263 LCNPGYEERIEQCQVCKVGYYRSLSSDVGCRKCPLHSYSVKEGATSCDCDKGYYRSETDPAAMPC 327

Human   326 TRPPSAPLNLISNVNETSVNLEWSSPQNTGGRQDISYNVVCKKCGAGDPSKCRPCGSGVHYTPQQ 390
            |||||||.|||||||||||.|:||.|.::|||||::||||||:| ..|..:|.|||..|.|:||:
Zfish   328 TRPPSAPHNLISNVNETSVLLDWSPPLSSGGRQDLTYNVVCKQC-VRDTQRCSPCGDDVRYSPQR 391

Human   391 NGLKTTKVSITDLLAHTNYTFEIWAVNGVSKYNPNPDQSVSVTVTTNQAAPSSIALVQAKEVTRY 455
            ..|::|:||:..|.|||||||:|||:|||||:||:|:|:||||:||||||||.:..||:|::||:
Zfish   392 LSLRSTRVSVHQLQAHTNYTFQIWAINGVSKHNPSPEQAVSVTLTTNQAAPSMVMSVQSKDITRH 456

Human   456 SVALAWLEPDRPNGVILEYEVKYYEKDQNERSYRIVRTAARNTDIKGLNPLTSYVFHVRARTAAG 520
            ::||.|.:|::|||||||||||||||||||||||||:|.:||.|||.|.||||||||||||||||
Zfish   457 TLALFWDQPEKPNGVILEYEVKYYEKDQNERSYRIVKTTSRNADIKDLTPLTSYVFHVRARTAAG 521

Human   521 YGDFSEPLEVTTNTVPSRIIGDGANSTVLLVSVSGS-VVLVVILIAAFVISRRRSKYSKAKQEAD 584
            |||||.|.|.:||||.:.::|...:|.|||:.|:|. |||::|||..|:.::|||||||.||  .
Zfish   522 YGDFSAPFEFSTNTVAAPVVGGVMSSAVLLLLVAGCVVVLLLILIITFIFTKRRSKYSKTKQ--G 584

Human   585 EEKHLNQGVRTYVDPFTYEDPNQAVREFAKEIDASCIKIEKVIGVGEFGEVCSGRLKVPGKREIC 649
            |:|::.||||.|||||||||||||:|||||||:.||||||||||:||||||||||||:|||||||
Zfish   585 EDKNVQQGVRIYVDPFTYEDPNQAIREFAKEINTSCIKIEKVIGIGEFGEVCSGRLKLPGKREIC 649

Human   650 VAIKTLKAGYTDKQRRDFLSEASIMGQFDHPNIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKN 714
            |||||||||:|::||.|||||||::||||||||||||||||||||||||||||||||||.|||||
Zfish   650 VAIKTLKAGFTEQQRLDFLSEASVIGQFDHPNIIHLEGVVTKCKPVMIITEYMENGSLDMFLRKN 714

Human   715 DGRFTVIQLVGMLRGIGSGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAY 779
            |||||||||||:||||.||||||||||||||||||||||||||||||||||||||||||:||.||
Zfish   715 DGRFTVIQLVGILRGIASGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDEPEGAY 779

Human   780 TTRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLP 844
            |||||||||||||||||.|||||||||||||||||||||||||||||||||||||||||||||||
Zfish   780 TTRGGKIPIRWTAPEAITYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLP 844

Human   845 PPMDCPIALHQLMLDCWQKERSDRPKFGQIVNMLDKLIRNPNSLKRTGTESSR--PNTALLDPSS 907
            |||:||:|||||||:||.:||:|||||.|||||||||||||.:||||..::||  |:|....||.
Zfish   845 PPMECPLALHQLMLECWMRERADRPKFSQIVNMLDKLIRNPATLKRTAGDASRSHPSTINHAPSE 909

Human   908 PEFSAVVSVGDWLQAIKMDRYKDNFTAAGYTTLEAVVHVNQEDLARIGITAITHQNKILSSVQAM 972
            ....::.||.|||:.|.:::|::||..|||:::|:|:.:|.||||::||:...||.||||||:.:
Zfish   910 CSAPSLASVDDWLKLIGLEQYRENFNTAGYSSIESVIPMNHEDLAKMGISCSAHQRKILSSVEDL 974

Human   973 RTQMQQMHGRMVPV 986
            .:.|.......|||
Zfish   975 LSGMHHRQDSKVPV 988

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EPHA4	NP_001291465.1	EphR_LBD_A4	30..203	CDD:198450	147/172 (85%)
		FN3	329..436	CDD:238020	68/106 (64%)
		FN3	441..532	CDD:238020	66/90 (73%)
		EphA2_TM	562..618	CDD:405290	39/55 (71%)
		PTKc_EphR_A	616..882	CDD:270651	242/265 (91%)
		SAM_EPH-A4	911..981	CDD:188944	30/69 (43%)
		PDZ-binding. /evidence=ECO:0000255	984..986		1/1 (100%)
epha4l	XP_687698.2	EphR_LBD	32..205	CDD:295439	147/172 (85%)
		FN3	331..437	CDD:238020	68/106 (64%)
		FN3	442..533	CDD:238020	66/90 (73%)
		EphA2_TM	540..616	CDD:291255	47/77 (61%)
		PTKc_EphR_A	616..882	CDD:270651	242/265 (91%)
		Pkinase_Tyr	621..878	CDD:285015	235/256 (92%)
		SAM_EPH-A4	913..983	CDD:188944	30/69 (43%)
		SAM	913..975	CDD:197735	29/61 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194329156
Domainoid	1	1.000	498	1.000	Domainoid score	I2792
eggNOG	1	0.900	-	-		E2759_KOG0196
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1537	1.000	Inparanoid score	I887
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG45908
OrthoDB	1	1.010	-	-		D397694at33208
OrthoFinder	1	1.000	-	-		FOG0000086
OrthoInspector	1	1.000	-	-		oto42519
orthoMCL	1	0.900	-	-		OOG6_100189
Panther	1	1.100	-	-	O	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X82
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.770