Protein Alignment EPHA4 and epha4

DIOPT Version :10

• Sequence 1: NP_004429.1
• Gene: EPHA4 / 2043
• HGNCID: 3388
• Length: 986
• Species: Homo sapiens
• Sequence 2: XP_012825631.1
• Gene: epha4 / 100216124
• XenbaseID: XB-GENE-1015803
• Length: 986
• Species: Xenopus tropicalis
• Alignment Length: 987
• Identity: 883/987 - (89%)
• Similarity: 939/987 - (95%)
• Gaps: 2/987 - (0%)

Human     1 MAGIFYFALFSCLFGICDAVTGSRVYPANEVTLLDSRSVQGELGWIASPLEGGWEEVSIMDEKNT 65
            ||||.:..||..|||:|.||||||:|||:||||||||||||||||||||||||||||||||||||
 Frog     1 MAGIVHGILFCGLFGLCWAVTGSRIYPASEVTLLDSRSVQGELGWIASPLEGGWEEVSIMDEKNT 65

Human    66 PIRTYQVCNVMEPSQNNWLRTDWITREGAQRVYIEIKFTLRDCNSLPGVMGTCKETFNLYYYESD 130
            ||||||||||||.|||||||||||.|.||||||:||||||||||||||||||||||||||||||:
 Frog    66 PIRTYQVCNVMESSQNNWLRTDWIPRSGAQRVYVEIKFTLRDCNSLPGVMGTCKETFNLYYYESN 130

Human   131 NDKERFIRENQFVKIDTIAADESFTQVDIGDRIMKLNTEIRDVGPLSKKGFYLAFQDVGACIALV 195
            |||||||||.|:|||||||||||||||||||||||||||:|||||||||||||||||||||||||
 Frog   131 NDKERFIRETQYVKIDTIAADESFTQVDIGDRIMKLNTEVRDVGPLSKKGFYLAFQDVGACIALV 195

Human   196 SVRVFYKKCPLTVRNLAQFPDTITGADTSSLVEVRGSCVNNSEEKDVPKMYCGADGEWLVPIGNC 260
            |||||||||||||||||||||||||:|||||||||||||:|||||||||||||||||||||||||
 Frog   196 SVRVFYKKCPLTVRNLAQFPDTITGSDTSSLVEVRGSCVDNSEEKDVPKMYCGADGEWLVPIGNC 260

Human   261 LCNAGHEERSGECQACKIGYYKALSTDATCAKCPPHSYSVWEGATSCTCDRGFFRADNDAASMPC 325
            |||||.|||:|.|||||:||||||||||.|:|||||||::.||:||||||||:||||.|.|||||
 Frog   261 LCNAGFEERNGGCQACKVGYYKALSTDAACSKCPPHSYALREGSTSCTCDRGYFRADTDPASMPC 325

Human   326 TRPPSAPLNLISNVNETSVNLEWSSPQNTGGRQDISYNVVCKKCGAGDPSKCRPCGSGVHYTPQQ 390
            |||||||.||||||||||||||||.|||:|||.|::||:|||:||: |.::||||||||||:|||
 Frog   326 TRPPSAPQNLISNVNETSVNLEWSPPQNSGGRPDVTYNLVCKRCGS-DLTRCRPCGSGVHYSPQQ 389

Human   391 NGLKTTKVSITDLLAHTNYTFEIWAVNGVSKYNPNPDQSVSVTVTTNQAAPSSIALVQAKEVTRY 455
            |||||||||||||.||||||||:||:|||||.||..||:|||||||||||||::..:|.||:||:
 Frog   390 NGLKTTKVSITDLQAHTNYTFEVWAINGVSKQNPGQDQAVSVTVTTNQAAPSTVTQIQPKEITRH 454

Human   456 SVALAWLEPDRPNGVILEYEVKYYEKDQNERSYRIVRTAARNTDIKGLNPLTSYVFHVRARTAAG 520
            ||:|.|.||:|.||||||||||||||||||||||||:||:|:.|||||||||:||||||||||||
 Frog   455 SVSLTWPEPERANGVILEYEVKYYEKDQNERSYRIVKTASRSADIKGLNPLTAYVFHVRARTAAG 519

Human   521 YGDFSEPLEVTTNTVPSRIIGDGANSTVLLVSVSGSVVLVVILIAAFVISRRRSKYSKAKQEADE 585
            ||:||.|.|.|||||||.:||:||:.|||||||:||:||||||||||||||||||||||||||||
 Frog   520 YGEFSGPFEFTTNTVPSPMIGEGASPTVLLVSVAGSIVLVVILIAAFVISRRRSKYSKAKQEADE 584

Human   586 EKHLNQGVRTYVDPFTYEDPNQAVREFAKEIDASCIKIEKVIGVGEFGEVCSGRLKVPGKREICV 650
            ||||||||:||||||||||||||||||||||||||||||||||||||||||||||||||||||.|
 Frog   585 EKHLNQGVKTYVDPFTYEDPNQAVREFAKEIDASCIKIEKVIGVGEFGEVCSGRLKVPGKREIYV 649

Human   651 AIKTLKAGYTDKQRRDFLSEASIMGQFDHPNIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKND 715
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   650 AIKTLKAGYTDKQRRDFLSEASIMGQFDHPNIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKND 714

Human   716 GRFTVIQLVGMLRGIGSGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYT 780
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   715 GRFTVIQLVGMLRGIGSGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYT 779

Human   781 TRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPP 845
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   780 TRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPP 844

Human   846 PMDCPIALHQLMLDCWQKERSDRPKFGQIVNMLDKLIRNPNSLKRTGTE-SSRPNTALLDPSSPE 909
            ||||||||||||||||||||||||||||||:||||||||||||||||.: |||.|||||||||||
 Frog   845 PMDCPIALHQLMLDCWQKERSDRPKFGQIVSMLDKLIRNPNSLKRTGLDNSSRTNTALLDPSSPE 909

Human   910 FSAVVSVGDWLQAIKMDRYKDNFTAAGYTTLEAVVHVNQEDLARIGITAITHQNKILSSVQAMRT 974
            :|.|.||.||||||||:||||||||||||:|||||||||:||.||||::.:||||||||||.|||
 Frog   910 WSQVASVLDWLQAIKMERYKDNFTAAGYTSLEAVVHVNQDDLTRIGISSPSHQNKILSSVQGMRT 974

Human   975 QMQQMHGRMVPV 986
            |||||.||||||
 Frog   975 QMQQMQGRMVPV 986

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EPHA4	NP_004429.1	EphR_LBD_A4	30..203	CDD:198450	164/172 (95%)
		FN3	329..436	CDD:238020	85/106 (80%)
		FN3	441..532	CDD:238020	68/90 (76%)
		EphA2_TM	562..618	CDD:464211	54/55 (98%)
		PTKc_EphR_A	616..882	CDD:270651	263/265 (99%)
		SAM_EPH-A4	911..981	CDD:188944	57/69 (83%)
		PDZ-binding. /evidence=ECO:0000255	984..986		1/1 (100%)
epha4	XP_012825631.1	EphR_LBD_A4	30..203	CDD:198450	164/172 (95%)
		FN3	329..435	CDD:238020	85/106 (80%)
		FN3	440..531	CDD:238020	68/90 (76%)
		EphA2_TM	550..617	CDD:464211	63/66 (95%)
		PTKc_EphR_A	615..881	CDD:270651	263/265 (99%)
		SAM_EPH-A4	911..981	CDD:188944	57/69 (83%)