DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment EPHA4 and epha4

DIOPT Version :9

Sequence 1:	NP_001291465.1	Gene:	EPHA4 / 2043	HGNCID:	3388	Length:	986	Species:	Homo sapiens
Sequence 2:	XP_012825631.1	Gene:	epha4 / 100216124	XenbaseID:	XB-GENE-1015803	Length:	986	Species:	Xenopus tropicalis

Alignment Length:	987	Identity:	883/987 - (89%)
Similarity:	939/987 - (95%)	Gaps:	2/987 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MAGIFYFALFSCLFGICDAVTGSRVYPANEVTLLDSRSVQGELGWIASPLEGGWEEVSIMDEKNT 65
            ||||.:..||..|||:|.||||||:|||:||||||||||||||||||||||||||||||||||||
Frog     1 MAGIVHGILFCGLFGLCWAVTGSRIYPASEVTLLDSRSVQGELGWIASPLEGGWEEVSIMDEKNT 65

Human    66 PIRTYQVCNVMEPSQNNWLRTDWITREGAQRVYIEIKFTLRDCNSLPGVMGTCKETFNLYYYESD 130
            ||||||||||||.|||||||||||.|.||||||:||||||||||||||||||||||||||||||:
Frog    66 PIRTYQVCNVMESSQNNWLRTDWIPRSGAQRVYVEIKFTLRDCNSLPGVMGTCKETFNLYYYESN 130

Human   131 NDKERFIRENQFVKIDTIAADESFTQVDIGDRIMKLNTEIRDVGPLSKKGFYLAFQDVGACIALV 195
            |||||||||.|:|||||||||||||||||||||||||||:|||||||||||||||||||||||||
Frog   131 NDKERFIRETQYVKIDTIAADESFTQVDIGDRIMKLNTEVRDVGPLSKKGFYLAFQDVGACIALV 195

Human   196 SVRVFYKKCPLTVRNLAQFPDTITGADTSSLVEVRGSCVNNSEEKDVPKMYCGADGEWLVPIGNC 260
            |||||||||||||||||||||||||:|||||||||||||:|||||||||||||||||||||||||
Frog   196 SVRVFYKKCPLTVRNLAQFPDTITGSDTSSLVEVRGSCVDNSEEKDVPKMYCGADGEWLVPIGNC 260

Human   261 LCNAGHEERSGECQACKIGYYKALSTDATCAKCPPHSYSVWEGATSCTCDRGFFRADNDAASMPC 325
            |||||.|||:|.|||||:||||||||||.|:|||||||::.||:||||||||:||||.|.|||||
Frog   261 LCNAGFEERNGGCQACKVGYYKALSTDAACSKCPPHSYALREGSTSCTCDRGYFRADTDPASMPC 325

Human   326 TRPPSAPLNLISNVNETSVNLEWSSPQNTGGRQDISYNVVCKKCGAGDPSKCRPCGSGVHYTPQQ 390
            |||||||.||||||||||||||||.|||:|||.|::||:|||:||: |.::||||||||||:|||
Frog   326 TRPPSAPQNLISNVNETSVNLEWSPPQNSGGRPDVTYNLVCKRCGS-DLTRCRPCGSGVHYSPQQ 389

Human   391 NGLKTTKVSITDLLAHTNYTFEIWAVNGVSKYNPNPDQSVSVTVTTNQAAPSSIALVQAKEVTRY 455
            |||||||||||||.||||||||:||:|||||.||..||:|||||||||||||::..:|.||:||:
Frog   390 NGLKTTKVSITDLQAHTNYTFEVWAINGVSKQNPGQDQAVSVTVTTNQAAPSTVTQIQPKEITRH 454

Human   456 SVALAWLEPDRPNGVILEYEVKYYEKDQNERSYRIVRTAARNTDIKGLNPLTSYVFHVRARTAAG 520
            ||:|.|.||:|.||||||||||||||||||||||||:||:|:.|||||||||:||||||||||||
Frog   455 SVSLTWPEPERANGVILEYEVKYYEKDQNERSYRIVKTASRSADIKGLNPLTAYVFHVRARTAAG 519

Human   521 YGDFSEPLEVTTNTVPSRIIGDGANSTVLLVSVSGSVVLVVILIAAFVISRRRSKYSKAKQEADE 585
            ||:||.|.|.|||||||.:||:||:.|||||||:||:||||||||||||||||||||||||||||
Frog   520 YGEFSGPFEFTTNTVPSPMIGEGASPTVLLVSVAGSIVLVVILIAAFVISRRRSKYSKAKQEADE 584

Human   586 EKHLNQGVRTYVDPFTYEDPNQAVREFAKEIDASCIKIEKVIGVGEFGEVCSGRLKVPGKREICV 650
            ||||||||:||||||||||||||||||||||||||||||||||||||||||||||||||||||.|
Frog   585 EKHLNQGVKTYVDPFTYEDPNQAVREFAKEIDASCIKIEKVIGVGEFGEVCSGRLKVPGKREIYV 649

Human   651 AIKTLKAGYTDKQRRDFLSEASIMGQFDHPNIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKND 715
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Frog   650 AIKTLKAGYTDKQRRDFLSEASIMGQFDHPNIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKND 714

Human   716 GRFTVIQLVGMLRGIGSGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYT 780
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Frog   715 GRFTVIQLVGMLRGIGSGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYT 779

Human   781 TRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPP 845
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Frog   780 TRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPP 844

Human   846 PMDCPIALHQLMLDCWQKERSDRPKFGQIVNMLDKLIRNPNSLKRTGTE-SSRPNTALLDPSSPE 909
            ||||||||||||||||||||||||||||||:||||||||||||||||.: |||.|||||||||||
Frog   845 PMDCPIALHQLMLDCWQKERSDRPKFGQIVSMLDKLIRNPNSLKRTGLDNSSRTNTALLDPSSPE 909

Human   910 FSAVVSVGDWLQAIKMDRYKDNFTAAGYTTLEAVVHVNQEDLARIGITAITHQNKILSSVQAMRT 974
            :|.|.||.||||||||:||||||||||||:|||||||||:||.||||::.:||||||||||.|||
Frog   910 WSQVASVLDWLQAIKMERYKDNFTAAGYTSLEAVVHVNQDDLTRIGISSPSHQNKILSSVQGMRT 974

Human   975 QMQQMHGRMVPV 986
            |||||.||||||
Frog   975 QMQQMQGRMVPV 986

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EPHA4	NP_001291465.1	EphR_LBD_A4	30..203	CDD:198450	164/172 (95%)
		FN3	329..436	CDD:238020	85/106 (80%)
		FN3	441..532	CDD:238020	68/90 (76%)
		EphA2_TM	562..618	CDD:405290	54/55 (98%)
		PTKc_EphR_A	616..882	CDD:270651	263/265 (99%)
		SAM_EPH-A4	911..981	CDD:188944	57/69 (83%)
		PDZ-binding. /evidence=ECO:0000255	984..986		1/1 (100%)
epha4	XP_012825631.1	EphR_LBD_A4	30..203	CDD:198450	164/172 (95%)
		FN3	329..435	CDD:238020	85/106 (80%)
		FN3	440..531	CDD:238020	68/90 (76%)
		EphA2_TM	551..615	CDD:373140	60/63 (95%)
		PTKc_EphR_A	615..881	CDD:270651	263/265 (99%)
		SAM_EPH-A4	911..981	CDD:188944	57/69 (83%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	524	1.000	Domainoid score	I3353
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20933
Inparanoid	1	1.050	1811	1.000	Inparanoid score	I886
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG45908
OrthoDB	1	1.010	-	-		D29780at32523
OrthoFinder	1	1.000	-	-		FOG0000086
OrthoInspector	1	1.000	-	-		oto156441
Panther	1	1.100	-	-	LDO	PTHR24416
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2895
SonicParanoid	1	1.000	-	-		X82
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	13.110