DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sorbs1 and CAP

DIOPT Version :9

Sequence 1:	XP_011245474.1	Gene:	Sorbs1 / 20411	MGIID:	700014	Length:	2033	Species:	Mus musculus
Sequence 2:	NP_001369075.1	Gene:	CAP / 36084	FlyBaseID:	FBgn0033504	Length:	2568	Species:	Drosophila melanogaster

Alignment Length:	2420	Identity:	479/2420 - (19%)
Similarity:	751/2420 - (31%)	Gaps:	929/2420 - (38%)

- Green bases have known domain annotations that are detailed below.

Mouse    31 RARSISAVKIIPVKTVKSPSGLVLPPD--MDPTKICTGKGTVT---LRASSSYRGTPS--SSPVS 88
            :|.:::...::.:.|  ..|.|:..||  |..|...|...:.|   ....:...|..|  |:||:
  Fly   655 QAAALAERALVDLDT--DASRLIARPDDEMSSTSTTTADRSETEAETETETEREGEQSRESTPVN 717

Mouse    89 PQESPKHESKSGLEPEDPS-------ADEWKLSSSADTNGNA-----QPSPLAAKGYRSVHPSLS 141
            ...:......|.|....|:       ||..:|:...:.:|.:     ..|||||.....|.   :
  Fly   718 ANPTLASSQSSLLSAATPTPTPTPTPADREQLAKDTNVSGGSTVSFGAASPLAATREEFVR---N 779

Mouse   142 ADK-----------------PQVLSPPCLPFP-----------------------QEDRFAWQSP 166
            .||                 |:..|||.:|.|                       ||...:..|.
  Fly   780 MDKVRELIEMTRREQEQGELPRSPSPPPVPPPPASVPPYSPESSSFHLASLQLKRQESNDSHCSD 844

Mouse   167 TIHRNYKDSLYMSSPKP---YIPPSTPSQQNPS---LPTPTSVPLGARLAPRNASCPRSLLLGSM 225
            :...:...::.::||.|   ..||:.|.:|.|:   :|.|.|.|     ||
  Fly   845 STTHSQCTAINLASPPPPPTAQPPTPPLRQKPAPPPVPQPVSPP-----AP-------------- 890

Mouse   226 GLEVPSQPQQYYVASRLVYSKNVSSNTRCEA-TGNKQVSSLYVPC-------------------L 270
              ..|....:..||..:.   |.:::...:| |..:.:..|.:.|                   :
  Fly   891 --PTPQSEPELSVADSVA---NANADVDADADTDTEAIKKLRLLCTEQLASMPYGEQVLEELASV 950

Mouse   271 SNNICRASSENYP------PVARD---SAPDTPSEAAGTQAPAP-------CLVPGTATVGTGKP 319
            :.||...|....|      |..::   :|.::.|.:|....|..       ||.||...:...:.
  Fly   951 AQNISDQSQNKMPYPMPQLPHIKELQLNANESKSSSAWLGLPTQSDPKLLVCLSPGQRDLVNNQT 1015

Mouse   320 PPAPPPDPPKLFFDNR-----------KDDGNRGENHTLGTWASFPD---AVRPPRLGPQVTSDP 370
            .|....|..:.|.:.|           :.|..:.::..|.|.|...:   ::.||  .|.|...|
  Fly  1016 QPDDLLDAHQKFVERRGYHELSKAQVLEQDHQQQQSEMLKTAAMMRELRKSLSPP--APPVPPPP 1078

Mouse   371 ENQKNKETYLLQPCYPAKGATSSSSAPSEVIVVPLYLVNTDRGQGQEGTARTPASLGPLGCV--- 432
            ...|:.||        |..||:..:|..:........:........|...|..|.||.....
  Fly  1079 VPVKSAET--------AAKATAHENAKRDDASEQKQKIAACESSSLENKPRRAADLGAQQSAEQR 1135

Mouse   433 ---------HTVPATTPAASPLTFPTLDD-------FIPPHL------QRR-------PHHSQPA 468
                     |.....|.::....|||||.       ..|.|.      ||:       |.| ||.
  Fly  1136 QSSSTTTSSHKATTETMSSDTAKFPTLDSMESELARMFPQHKGDIFEEQRKRFSNIEFPSH-QPV 1199

Mouse   469 SACGSLS-----------------------------------PASQTSPPSPPPPLVPPVPEDLH 498
            |.....|                                   |..|..||.||||::.....:.:
  Fly  1200 SQTKRYSNIETSSYESKKRMENGQVVYDVSTSSHEKKEQGDPPKDQPVPPVPPPPIMSATKLNGN 1264

Mouse   499 RGLEPDL------PGAVSSTGS----------------PLLNEVSSSHIETDS----QDFPPTSR 537
            ..::.|:      |...|.:||                ....|........|.    :||...|:
  Fly  1265 TFIDGDVAPKNSQPSRESGSGSGNGTYEEFRQRAKAAADAFGEQREQQNGLDQDRVFKDFDRLSQ 1329

Mouse   538 PSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSD------PASERRAGEQDPVPTPAELTSPGRAS 596
            ...|.            ||..||::::.:|:.|      |||.....::......|.:....|..
  Fly  1330 QMHAE------------LQSTREKREKSASMYDLSGFTRPASGHPRLDELQQRRHAHMQELEREI 1382

Mouse   597 ERRAKDASRRV--VRSTQDLSDVSTDEVGIPLRNTERSKDW-----------YKTMFKQIHKLNR 648
            ||.||....|:  |....:.:...|.|:.|.|....|..:.           :.|:....|.:.:
  Fly  1383 ERSAKSRQERMSSVPRQMEATPPRTHEIPIELEPRSRRAESLCNLNEPPPRPHTTVGHYNHPVVQ 1447

Mouse   649 DDDSDVHSPRYS----FSDDTKSPLSVPRSKSEMNYIEGEKVVKRSATLP-LPARSSSLKSSPE- 707
            ||.|     ||:    :|::...|.:   .:.|:.|....:........| |.|.::.|.||.:
  Fly  1448 DDWS-----RYANDLGYSENIARPFA---REVEICYQRQNQRTPHCIRAPRLSASTNDLSSSSQY 1504

Mouse   708 ----------RNDWEP--PDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSRDISPEEIDLKNE 760
                      |....|  ...:...|.:.....|:.|..|....:.|..:  |.:||
  Fly  1505 SYDTFNAYGGRRTHAPMLNQAQQQQRPHYGSCYSMIERDPNPRYISTTSR--RGVSP-------- 1559

Mouse   761 PWYKFFSELEFGRPPPKKIWDYTPGDCSILP----REDRKTNLEKDLSFCQ--------AELEAD 813
                        .|||..    ||....:.|    |:.|:::|.::|...|        .||:.:
  Fly  1560 ------------APPPVA----TPQQQQVPPPAYDRQQRRSSLPRELHEQQLKYILSKEEELKFE 1608

Mouse   814 LEKVETVNKSPSANSPQSSAVSPTPDITSEPPGYIYSSNFHAVKRESDGTPGGLASLENERQIYK 878
            :|:::. .:.......|.:.|.|.|.                 :|||......|.:| :|.::::
  Fly  1609 VERLQQ-ERRRLMEEMQRAPVLPAPQ-----------------RRESYRPAAKLPTL-SEDEVFR 1654

Mouse   879 SVLEGGDIPLQGLSGLKRPSSSASTKV-DRKGGNAH-MISSSSVHSRTFHTSNALGPGCKHKKPL 941
                            ::.:.....|| :|:....| :|..|.:.....|:
  Fly  1655 ----------------QQMAEEWMNKVAEREERRQHKIIRISKIEDEHDHS-------------- 1689

Mouse   942 SAAKACISEILPSKFKPR---LSAPSALLQEQKSVLLPSEKAQSCENLCVSLNDSKRGLPLRV-- 1001
            :..||.||:....:.|.|   ||.|:....|..:...|...|||      .........|:|:
  Fly  1690 AVDKATISDEFLDRVKERRHKLSMPADSDWESGAESQPQPAAQS------QPESDVEAPPVRILE 1748

Mouse  1002 GGSIENL--LMRSRRDYDSKSSSTMSLQEYGTSSRRPCPLSRKAGLHFSMFYRDMHQINRAGLSL 1064
            |.:..||  |.|..|::          .::.||.:.|         ..:...|...|..|...:.
  Fly  1749 GQAEANLRQLPRHLREF----------AKFSTSEQLP---------DGAQMERHEEQERREEATD 1794

Mouse  1065 GSISSSSVR-DLASHFERSRLTLA-------------RGELGASQEGSEHIPKHTVSSRITAFEQ 1115
            .:.||::.: .:...::.|||..:             ||.|...:..:..:..|.:...:|:
  Fly  1795 NAHSSATKKTSIVKTYKVSRLPPSVQGEFPGQFSGGNRGRLYRERSQTARLVSHNIPLELTS--- 1856

Mouse  1116 LIQRSRSMPSLDFSGRLSKSPTPVLSRSGLTSARSAESLLES----------------------- 1157
               ...|.|..||:.....||.|     |.::..|..||::|
  Fly  1857 ---NHSSSPDSDFNPGCGSSPAP-----GSSTQSSIPSLVQSPTPAPPPPIEPLNPSSSTAGGIL 1913

Mouse  1158 -TKL------------------------------RPREM----------------DGM------- 1168
             |.|                              |||:|                |||
  Fly  1914 GTALLLGLSLLTAWNKFIYKVKHEYMSEPETGSDRPRKMAQLGRRQYDGIGPVTNDGMPIILRSE 1978

Mouse  1169 ---------------------------------------DSGGVYASPTCSNMADHA-LSFRSLV 1193
                                                   .|.|..:.|..:..:|:: :.:|:..
  Fly  1979 VKEPHQHEWYKRLYQTIHKQKNGDDFVIRYKCPRARPSYKSNGYVSEPEPNYDSDYSTVRYRTQN 2043

Mouse  1194 PSEPLSICSDELDHCSNVSNDSREGSGGSVHGDFP---KHRLNKCKGTCPASYTRFTTIRKHEQQ 1255
            |....|:.|     ..||.|.:::   ..::|..|   |...|..|.. |.....:||  .|...
  Fly  2044 PHRVQSVSS-----AVNVRNLNQD---EKLYGTMPNPIKSAQNSYKNQ-PGRIENYTT--GHSSV 2097

Mouse  1256 SSRQ-SDWRSDSRGDKNSLLRNIHLMSPL--PFRLKKPLQQHPRQPPPSDSSESPAGQKADLPCH 1317
            |.:: .:|..:.....|..|....| |||  ...|.:.|.:....  .|||  :...:|.::|
  Fly  2098 SEKEKKEWWDEVMDIFNGNLEQSKL-SPLYTEGNLSRALAKESGY--TSDS--NLVFRKKEVP-- 2155

Mouse  1318 DPQDQPHSAGKPLVPARLSSRHTMARLSHNLEPPL--------DRPAGLEDCTRAINNGNPV--- 1371
                    ...||.|  :..:.....|....||||        ::|..|:.....|....||
  Fly  2156 --------VSSPLSP--VEQKQAYKSLQAGGEPPLLGFRKPAPEKPRDLDPNAPPIPPQPPVKGL 2210

Mouse  1372 -----PYSDHGLDRNN-NPQSELAAAHGDSESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRR 1430
                 |||...:|.:: |...:....|...::          .|.||...|:.:..:||..::||
  Fly  2211 SSYDFPYSTDTVDGSDVNIHFKTPIRHEQRQN----------LSEEELAIRQAEHMQKLYHEERR 2265

Mouse  1431 LKREQEEADIAARRHT-GVIPTHHQFITNERFGDLLNIDDTAKRKSGLEMRPARAKFDFKAQTLK 1494
            .|..||..|:.:|||| ...|:....|...|:.| ...|.|.|...| ....|||.|:|:.||.|
  Fly  2266 RKYLQELQDMNSRRHTDNFTPSQKSPIALNRYDD-FPTDVTLKSLVG-PKTVARALFNFQGQTSK 2328

Mouse  1495 ELPLQKGDVVYIYRQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPRKLAPVQVLEYGEAIAK 1559
            ||..:|||.:||.||||.|||||||:..:|:.|.:|:|::.......|.| .|.:    |:|.||
  Fly  2329 ELSFRKGDTIYIRRQIDANWYEGEHNAMIGLLPASYVEIVSRDGARTPSK-RPSE----GQARAK 2388

Mouse  1560 FNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVLKRPLVKTPVDYIDL 1624
            :||...:.:|:|..|||.:||.|:||.||:||:|  .:|:||||.:||:||           .|:
  Fly  2389 YNFQAQSGIELSLNKGELVTLTRRVDGNWFEGKI--ANRKGIFPCSYVEVL-----------TDI 2440

Mouse  1625 PYSSSPSRSATVSPQYTSHSKLIMPAPSSLPHPRRALSPEMHAITSEWISLTVGVPGRRSLAMTP 1689
            ......:|:.||                               |||:
  Fly  2441 GAEDIAARTTTV-------------------------------ITSQ------------------ 2456

Mouse  1690 PLPPLPEASVYDMDRLALSARARPSLPLSLPYSSWSDHSTLRPVVSPMALPPPHKAYSLAPSVQA 1754
                             .:...||:|
  Fly  2457 -----------------STTNLRPNL--------------------------------------- 2465

Mouse  1755 PLHVNGDGGIHIRQDGFSQPPPGNSDRVISELSDAFSSQSKRQPWREDGPYDRKAESEAGERYPG 1819

  Fly  2466 ----------------------------------------------------------------- 2465

Mouse  1820 GPKISKKSCLKPSDVVRCLSSEQRLSEFHTPEDSQSCKPLGGPFPAWETGPPELHRAVEADRKAA 1884
                         ||:|...:    :||:|                                 ..
  Fly  2466 -------------DVLRTNIN----NEFNT---------------------------------LT 2480

Mouse  1885 QSGVSQPSHHSLSAGPDLTESEKNYVEAVCNEIINIAEKSVHYCSTVSHPLDFHHKVPPSDNKSS 1949
            |:|...|:                   .:..|...:.:....:..|.|.||
  Fly  2481 QNGAQPPN-------------------GILKETRTLHKTDALHVDTSSEPL-------------- 2512

Mouse  1950 LIISQQPQAQQRRVTPDRSQPSLDLCSYQALYSYVPQNDDELELRDGDIVDVMEKCDDGWFVGTS 2014
                                      :|:|||.|.|||.|||||.:||:|.|:||||||||||||
  Fly  2513 --------------------------AYRALYKYRPQNSDELELLEGDVVHVLEKCDDGWFVGTS 2551

Mouse  2015 RRTRQFGTFPGNYVK 2029
            :||..|||||||||:
  Fly  2552 QRTGCFGTFPGNYVE 2566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sorbs1	XP_011245474.1	Sorb	608..654	CDD:128735	11/56 (20%)
		SH3_Sorbs1_1	1480..1534	CDD:212852	30/53 (57%)
		SH3_Sorbs1_2	1554..1611	CDD:212855	29/56 (52%)
		SH3_Sorbs1_3	1974..2032	CDD:212849	40/56 (71%)
CAP	NP_001369075.1	MDN1	<43..328	CDD:227596
		Sorb	1959..2003	CDD:413404	3/43 (7%)
		SH3_Sorbs_1	2315..2367	CDD:212715	29/51 (57%)
		SH3_Sorbs_2	2384..2436	CDD:212716	27/53 (51%)
		SH3_Sorbs_3	2514..2567	CDD:212714	40/53 (75%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	89	1.000	Domainoid score	I7826
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	291	1.000	Inparanoid score	I2770
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004115
OrthoInspector	1	1.000	-	-		otm42853
orthoMCL	1	0.900	-	-		OOG6_106599
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3387
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.860