DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sorbs3 and CAP

DIOPT Version :9

Sequence 1:	NP_035496.1	Gene:	Sorbs3 / 20410	MGIID:	700013	Length:	733	Species:	Mus musculus
Sequence 2:	NP_001369075.1	Gene:	CAP / 36084	FlyBaseID:	FBgn0033504	Length:	2568	Species:	Drosophila melanogaster

Alignment Length:	867	Identity:	230/867 - (26%)
Similarity:	339/867 - (39%)	Gaps:	298/867 - (34%)

- Green bases have known domain annotations that are detailed below.

Mouse    48 SNLDPSMQGLPAGLSLDDFIPGHLRTHIGSSSRGTRVPVIRNGGSNTLNFQFHDPAPRTVCNGCP 112
            |.|.||:||        :| ||..       |.|.|..:.|. .|.|.....|:.......|...
  Fly  1813 SRLPPSVQG--------EF-PGQF-------SGGNRGRLYRE-RSQTARLVSHNIPLELTSNHSS 1860

Mouse   113 PPRRDGSLNPD---------------PAWYQTWPGPGSRPSMSPKPPASQHAQNWSAT------- 155
            .|  |...||.               |:..|: |.|...|.:.|..|:|..|.....|
  Fly  1861 SP--DSDFNPGCGSSPAPGSSTQSSIPSLVQS-PTPAPPPPIEPLNPSSSTAGGILGTALLLGLS 1922

Mouse   156 ----WTK-----------------DSKRQ----DKRWVKYEGIGPVDESGMPIAPRSSVDSP--R 193
                |.|                 |..|:    .:|  :|:|||||...||||..||.|..|  .
  Fly  1923 LLTAWNKFIYKVKHEYMSEPETGSDRPRKMAQLGRR--QYDGIGPVTNDGMPIILRSEVKEPHQH 1985

Mouse   194 DWYRRMFQQIHRKM----------------------------PDLQLDWT-----LEDPPKVVSA 225
            :||:|::|.||::.                            |:...|::     .::|.:|.|.
  Fly  1986 EWYKRLYQTIHKQKNGDDFVIRYKCPRARPSYKSNGYVSEPEPNYDSDYSTVRYRTQNPHRVQSV 2050

Mouse   226 RASSAEPRHL-------GTLQRP--------ASRPGTTETSSGRNWNHSEETSR-------NTFN 268
             :|:...|:|       ||:..|        .::||..|..:..:.:.||:..:       :.||
  Fly  2051 -SSAVNVRNLNQDEKLYGTMPNPIKSAQNSYKNQPGRIENYTTGHSSVSEKEKKEWWDEVMDIFN 2114

Mouse   269 YNFRPSSSGLHPPNQVPRHREKVENVWTEDSWNQFLHELETGHKPKKPLV----DDPVEKPAQPI 329
            .|...|               |:..::||.:.::.|.: |:|:.....||    :.||..|..|:
  Fly  2115 GNLEQS---------------KLSPLYTEGNLSRALAK-ESGYTSDSNLVFRKKEVPVSSPLSPV 2163

Mouse   330 EVLLERELAKLSAELDKDLRAIETRLPSPKNSQAPRRPLEQPGLEQQPSARLSSAWRPNSPHAPY 394
                |::.|..|.:...:...:..|.|:|          |:|              |...|:||
  Fly  2164 ----EQKQAYKSLQAGGEPPLLGFRKPAP----------EKP--------------RDLDPNAP- 2199

Mouse   395 FSSSRPLSPHRMADGGGSPFLGRRDFVYPSSA----------REPSASERGSSPSRK-------- 441
                 |:.|.....|     |...||.|.:..          :.|...|:..:.|.:
  Fly  2200 -----PIPPQPPVKG-----LSSYDFPYSTDTVDGSDVNIHFKTPIRHEQRQNLSEEELAIRQAE 2254

Mouse   442 -------EEKKRK-----------------------------------------------AARLK 452
                   ||::||                                               .||..
  Fly  2255 HMQKLYHEERRRKYLQELQDMNSRRHTDNFTPSQKSPIALNRYDDFPTDVTLKSLVGPKTVARAL 2319

Mouse   453 FDFQAQSPKELSLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVLPADEIPKPIKPPTYQV 517
            |:||.|:.||||.:|||.:||.:::|.||.||||:..:|:.||:|||::..|....|.|.|:
  Fly  2320 FNFQGQTSKELSFRKGDTIYIRRQIDANWYEGEHNAMIGLLPASYVEIVSRDGARTPSKRPS--- 2381

Mouse   518 LEYGDAVAQYTFKGDLEVELSFRKGERICLIRKVNEHWYEGRITGTGRQGIFPASYVQINREPRL 582
              .|.|.|:|.|:....:|||..|||.:.|.|:|:.:|:||:|  ..|:||||.|||::
  Fly  2382 --EGQARAKYNFQAQSGIELSLNKGELVTLTRRVDGNWFEGKI--ANRKGIFPCSYVEV------ 2436

Mouse   583 RLCDDGPQLPASPNPTTTAHLSSHSHPSSIPVDPTDWGG--RTSPRRSAFPFPITLQEPRS--QT 643
             |.|.|.:..|:...|.....|:.:...::.|..|:...  .|..:..|.|....|:|.|:  :|
  Fly  2437 -LTDIGAEDIAARTTTVITSQSTTNLRPNLDVLRTNINNEFNTLTQNGAQPPNGILKETRTLHKT 2500

Mouse   644 QSLNTPGPTLSHPRATSRPINLGPSSPNTEIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCD 708
            .:|        |...:|.|:              .|||:|:|||||.|||||.|||.|.|:::||
  Fly  2501 DAL--------HVDTSSEPL--------------AYRALYKYRPQNSDELELLEGDVVHVLEKCD 2543

Mouse   709 DGWFVGVSRRTQKFGTFPGNYV 730
            ||||||.|:||..|||||||||
  Fly  2544 DGWFVGTSQRTGCFGTFPGNYV 2565

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sorbs3	NP_035496.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..51		1/2 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	129..165		12/67 (18%)
		Sorb	165..214	CDD:128735	22/78 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	224..285		16/82 (20%)
		PTZ00449	<306..>445	CDD:185628	32/167 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	352..448		23/167 (14%)
		Binds to vinculin	444..579		60/181 (33%)
		SH3_Vinexin_1	447..501	CDD:212854	29/100 (29%)
		SH3_Vinexin_2	521..576	CDD:212857	26/54 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	584..672		19/91 (21%)
		Binds to SOS. /evidence=ECO:0000250	674..733		39/57 (68%)
		SH3_Vinexin_3	676..733	CDD:212851	39/55 (71%)
CAP	NP_001369075.1	MDN1	<43..328	CDD:227596
		Sorb	1959..2003	CDD:413404	20/43 (47%)
		SH3_Sorbs_1	2315..2367	CDD:212715	27/51 (53%)
		SH3_Sorbs_2	2384..2436	CDD:212716	25/53 (47%)
		SH3_Sorbs_3	2514..2567	CDD:212714	39/52 (75%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	89	1.000	Domainoid score	I7826
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004115
OrthoInspector	1	1.000	-	-		otm42853
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8484
SonicParanoid	1	1.000	-	-		X3387
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.940