DRSC/TRiP Functional Genomics Resources

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Protein Alignment EPHA1 and Alk

DIOPT Version :10

Sequence 1:NP_005223.4 Gene:EPHA1 / 2041 HGNCID:3385 Length:976 Species:Homo sapiens
Sequence 2:NP_652600.1 Gene:Alk / 53425 FlyBaseID:FBgn0040505 Length:1701 Species:Drosophila melanogaster


Alignment Length:648 Identity:180/648 - (27%)
Similarity:263/648 - (40%) Gaps:142/648 - (21%)


- Green bases have known domain annotations that are detailed below.


Human   332 PPSAPRNLSFSASGTQLSLRWEPPADTGGRQDVRYSVRCSQCQGTA--QDGGPCQPC-------G 387
            |..||.  |...:|..|:.:...|   ||....:.....|...|.|  |.|.....|       |
  Fly   920 PLQAPE--SGQINGEPLNKKTAGP---GGGWRAKEDQALSPTYGAALLQGGRGGHSCYVELADNG 979

Human   388 VGVH------FSPGARGLTTPAVHVNGLEPYANYTFNVEAQNGVSGLGSSGHASTSVS---ISMG 443
            ..||      |..|..|..|.    .|...||.....:...||.   |.|.:.|.|.|   ||..
  Fly   980 TSVHRHGQGGFGGGGGGCNTG----GGGGGYAGGDVYLTESNGE---GGSSYISPSRSLREISEI 1037

Human   444 HAESLSGLSLRLVKKEPRQLELTWAGSRPRSPGANLTYELHVLNQDEERYQMVLEPRVLLTELQP 508
            ||.:.||....::              .|...|....|....|  ||.|                
  Fly  1038 HAGASSGPGAIII--------------IPAIEGCGCDYRCVAL--DEFR---------------- 1070

Human   509 DTTYIVRVRMLTPLGPGPFSPDHEFRTSPPVSRGLTGGEIVAVIFGLLLGAALL---LGILVFR- 569
                 .:||.:.|.|   :|...:..|:..:...........::..|::..|:|   :..|:|. 
  Fly  1071 -----SKVRCICPDG---WSLKRDNHTACEIREEAGKSSFQYLVSILMISLAVLFICIAALIFML 1127

Human   570 SRRAQRQRQQRQRDRATDVDREDKLW-----------------------LKPYVDLQAYEDPAQG 611
            ..|.||::|.::|.:.. |:::.:|.                       |..::|:.:....|:.
  Fly  1128 YNRYQRKKQSKKRHKML-VEQDLQLTRLRNNIDDSNLNNFNPNYGCDGILNGHIDVNSLPQVARD 1191

Human   612 ALDFTRELDPAWLMVDTVIGEGEFGEVYRGTLRLPSQDC--KTVAIKTLKDTSPGGQWWNFLREA 674
            :|.....|           |:|.|||||....|....|.  ..||:|||::.....:..:||:||
  Fly  1192 SLQLVNAL-----------GKGAFGEVYMALYRHRDGDAVEMGVAVKTLREDPKREKEEDFLKEA 1245

Human   675 TIMGQFSHPHILHLEGVVTKRKPIMIITEFMENGALDAFLR------EREDQLVPGQLVAMLQGI 733
            .||.:|:||:::||.||...|:|..|:.|.:..|.|..|||      ||...|....|:.....:
  Fly  1246 AIMAKFNHPNMVHLIGVCFDRQPYYIVLELLAGGDLQKFLRENRNTPERPSLLTMKDLLFCALDV 1310

Human   734 ASGMNYLSNHNYVHRDLAARNILVNQ---NLCCKVSDFGLTRLLDDFDGTYETQGGK--IPIRWT 793
            |.|..|:.:..::|||:||||.|::.   ....|::|||::|  |.:...|..:|||  :||:|.
  Fly  1311 AKGCRYMESKRFIHRDIAARNCLLSSKGPGRVVKIADFGMSR--DIYRSDYYRKGGKAMLPIKWM 1373

Human   794 APEAIAHRIFTTASDVWSFGIVMWEVLSFGDKPYGEMSNQEVMKSIEDGYRLPPPVDCPAPLYEL 858
            .|||....|||:.:|||||||::|||.|.|..||....|.:||:.:..|.||..|.:||..:|::
  Fly  1374 PPEAFLDGIFTSKTDVWSFGILLWEVFSLGRSPYPGQHNTQVMELVVRGGRLGSPTECPVSIYKV 1438

Human   859 MKNCWAYDRARRPHFQKLQAHLEQLLANPHSLRTIANFDPR-MTLRLPSLSGSDGIPYRTVSE 920
            |.:||......||.|..|..||           |....|.. |...||::.|.      |.||
  Fly  1439 MADCWNPTPEDRPTFITLLEHL-----------TACTQDASIMNAPLPNILGP------TASE 1484

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EPHA1NP_005223.4 EphR_LBD_A1 27..203 CDD:198447
fn3 334..431 CDD:394996 27/111 (24%)
FN3 453..535 CDD:238020 12/81 (15%)
EphA2_TM <586..621 CDD:464211 7/57 (12%)
Protein Kinases, catalytic domain 619..884 CDD:473864 104/277 (38%)
SAM_EPH-A1 912..974 CDD:188941 3/9 (33%)
PDZ-binding. /evidence=ECO:0000255 974..976
AlkNP_652600.1 MAM 288..447 CDD:99706
MAM 505..689 CDD:99706
PTKc_ALK_LTK 1186..1462 CDD:270632 106/299 (35%)
Blue background indicates that the domain is not in the aligned region.

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