Protein Alignment EPHA1 and Eph

DIOPT Version :10

• Sequence 1: NP_005223.4
• Gene: EPHA1 / 2041
• HGNCID: 3385
• Length: 976
• Species: Homo sapiens
• Sequence 2: NP_524625.3
• Gene: Eph / 43803
• FlyBaseID: FBgn0025936
• Length: 1096
• Species: Drosophila melanogaster
• Alignment Length: 1055
• Identity: 370/1055 - (35%)
• Similarity: 537/1055 - (50%)
• Gaps: 157/1055 - (14%)

Human    23 ARAKEVTLMDTSKAQGELGWLLDP--PK---DGWSEQQ--QILNGTPLYMYQDCPMQGRRDTDHW 80
            |.|.:|.|:||:: :..|.|...|  |:   .||.|:.  ..:.|.....|..|.: ...:.::|
  Fly    80 AHADQVVLLDTTR-EATLEWTRYPYGPQAQTPGWVEESFTDFVKGINWRSYVVCDV-AYHNVNNW 142

Human    81 LRSNWIYRGEEASRVHVELQFTVRDCKSFPGGAGPLGCKETFNLLYMESDQDVGIQLRRP----- 140
            |.|.:|.|| .|:|:::|:|||:|||..|||.|  |.|||||:||:.|.|    ...|.|
  Fly   143 LWSPFIDRG-SANRLYIEIQFTIRDCSLFPGNA--LSCKETFSLLFYEFD----AATREPPPWQT 200

Human   141 -LFQKVTTVAADQSFTIRDLVSGSVKLNVERCSLGRLTRRGLYLAFHNPGACVALVSVRVFYQRC 204
             .::.:..:||.:.   |...:..|.:|.|..|:. :.::|:|.||.:.|||:::::|:|:|..|
  Fly   201 DSYRLIARIAAGEG---RFNQNSDVDINTEVKSIA-VNKKGVYFAFRDQGACISVLAVKVYYITC 261

Human   205 PETLNGLAQFPDTLPGPAG----LVEVA-GTCLPHARASPRPSGAPRMHCSPDGEWLVPVGRCHC 264
            |......|.|.:|   |.|    ::|.. |||:.:|    .|...|...|..||:|.:..|.|.|
  Fly   262 PAVTENFAHFNET---PTGREITIIEKQNGTCVDNA----EPYETPTYLCKGDGKWTILTGGCRC 319

Human   265 EPGYEEGGSGEACVACPSGSYRMDMDTPHCLTCPQQSTAESEGATICTCESGHYRAPGEGPQVAC 329
            :.|||...:.:.|..||.|::: ..:...|..||..|.|...|:..|.|.||.||.|.:|..:.|
  Fly   320 KAGYEPNYTNKTCTECPLGTFK-SPEVTKCTPCPPNSNASKTGSPFCKCASGFYRHPNDGRHMPC 383

Human   330 TGPPSAPRNLS-FSASGTQLSLRWEPPA-------DTGGR---QDVRYSVRCSQCQGTAQDGGPC 383
            ..||:||.||: .....|...:.|..||       :|..:   .|:.|.::|:
  Fly   384 YSPPAAPTNLTLLFVDQTSAIISWSAPAKNESFSSETNSKIYHSDIVYKIKCN------------ 436

Human   384 QPCGVGVHFSPGARGLTTPAVHVNGLEPYANYTFNVEAQNGVSGLGS---SGHASTSVSIS---- 441
             .|...|.::|.........:.:..|||...||..:.|.|.||.:..   ..:.|:.|::|
  Fly   437 -ICSPNVVYNPSTDTFNETKITLTNLEPVTTYTVQIHAINSVSHINEFKRHSNESSLVAVSDIVF 500

Human   442 ----------------MGHAESL---------SGLSLRLVKKEPRQLELTWAGSRPRSPGANLTY 481
                            .|.||.:         :..:||::....:..:|.|  .:|......|.:
  Fly   501 SNTSLLNIPLDLNEVKTGQAEIVFTTESVLLSTVFNLRILAITNKDADLEW--DKPVQSDFPLEF 563

Human   482 ---------ELHVLNQDEERYQMVLEPRVLLTELQPDTTYIVRVRMLTPLGPGPFSPDHEFRTSP 537
                     ||..:|:.....:   |.:..:..|..:|.|..:||..|..|.|.:|.....:|..
  Fly   564 YEVRWFPKVELDAINKSALNTK---ETKAHIVGLLENTEYGFQVRCKTNNGFGSYSNMIYAQTLQ 625

Human   538 PVSRGLTGGEIVAVIFGLLLGAALLLGILVFRSRRAQRQRQQRQRDR-------------ATDVD 589
            .|.........:..|.|.::...|.|.|.:..:....|.:.|...|:             :.:|:
  Fly   626 SVGSVYDDSVQIRFIAGAIVTGVLFLVIFIIATVYFMRSKHQDDLDKKSTNHLPLPLDYASNEVN 690

Human   590 RED------KLWL----------KPYVDLQAYEDPAQGALDFTRELDPAWLMVDTVIGEGEFGEV 638
            ..|      ||.|          :.|||...||||.|...:|.||:|..::.::.:||.||||:|
  Fly   691 SMDTTPIVKKLHLNVTTPLFGNSRSYVDPHTYEDPNQAIREFAREIDANYITIEAIIGGGEFGDV 755

Human   639 YRGTLRLPS---QDCKTVAIKTLKDTSPGGQWWNFLREATIMGQFSHPHILHLEGVVTKRKPIMI 700
            .||.|::|.   ||. .|||||||..|......:||.||:|||||.||::::|:||||:..|:||
  Fly   756 CRGRLKIPPNFVQDI-DVAIKTLKPGSSEKARCDFLTEASIMGQFDHPNVIYLQGVVTRSNPVMI 819

Human   701 ITEFMENGALDAFLREREDQLVPGQLVAMLQGIASGMNYLSNHNYVHRDLAARNILVNQNLCCKV 765
            |||:||||:||.|||..:.:....||:.||:||||||:|||:.|||||||||||:|||..|.||:
  Fly   820 ITEYMENGSLDTFLRVNDGKFQTLQLIVMLRGIASGMSYLSDMNYVHRDLAARNVLVNAQLICKI 884

Human   766 SDFGLTRLLDDFDGTYETQGGKIPIRWTAPEAIAHRIFTTASDVWSFGIVMWEVLSFGDKPYGEM 830
            :||||:|.:::....|.|:|||||:|||||||||.|.||:||||||:|:|:|||:|:|::||...
  Fly   885 ADFGLSREIENASDAYTTRGGKIPVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMSYGERPYWNW 949

Human   831 SNQEVMKSIEDGYRLPPPVDCPAPLYELMKNCWAYDRARRPHFQKLQAHLEQLLANPHSLRTIAN 895
            |||:|:||||.|||||.|:|||..||:||.:||...|..||.|..:.:.|:.|...|.||.|
  Fly   950 SNQDVIKSIEKGYRLPAPMDCPEALYQLMLDCWQKQRTHRPTFASIVSTLDNLARQPQSLLT--- 1011

Human   896 FDPRMTLRLPSLSGS---DGIP----YRTVSEWLESIRMKRYILHFHSAGLDTMECVLELTAEDL 953
                 |...|...|:   ||..    :.:...|||.|:|.||..||..|.|...:.:..|||:.|
  Fly  1012 -----TRPSPESDGNHILDGQRGQNIFISTDLWLEHIKMSRYCHHFKEANLINAQQISRLTAQQL 1071

Human   954 TQMGITLPGHQKRIL 968
            :.|||||.||||:||
  Fly  1072 SDMGITLVGHQKKIL 1086

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EPHA1	NP_005223.4	EphR_LBD_A1	27..203	CDD:198447	62/188 (33%)
		fn3	334..431	CDD:394996	24/110 (22%)
		FN3	453..535	CDD:238020	19/90 (21%)
		EphA2_TM	<586..621	CDD:464211	16/50 (32%)
		Protein Kinases, catalytic domain	619..884	CDD:473864	150/267 (56%)
		SAM_EPH-A1	912..974	CDD:188941	27/61 (44%)
		PDZ-binding. /evidence=ECO:0000255	974..976
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439	62/187 (33%)
		FN3	387..476	CDD:238020	22/101 (22%)
		FN3	536..623	CDD:238020	19/91 (21%)
		EphA2_TM	640..738	CDD:464211	24/97 (25%)
		PTKc_EphR	736..1002	CDD:270629	150/266 (56%)
		SAM_1	1029..1092	CDD:425739	26/58 (45%)