Protein Alignment EPHA1 and Cad96Ca

DIOPT Version :10

• Sequence 1: NP_005223.4
• Gene: EPHA1 / 2041
• HGNCID: 3385
• Length: 976
• Species: Homo sapiens
• Sequence 2: NP_651349.1
• Gene: Cad96Ca / 43026
• FlyBaseID: FBgn0022800
• Length: 773
• Species: Drosophila melanogaster
• Alignment Length: 700
• Identity: 172/700 - (24%)
• Similarity: 265/700 - (37%)
• Gaps: 198/700 - (28%)

Human   387 GVGVHFS-PGARGLTTPAVHVNGLEPYANYTFNVEAQNGVSGLGSS--GHASTS----VSISMGH 444
            |:...|| ||..         |...|.....|.::.:.||..|..|  |.|..:    ::::.|.
  Fly    92 GIEPRFSLPGGE---------NDASPPEKIPFQIDRETGVVTLNESLAGRAGQNFLIYITVTDGS 147

Human   445 AESLSGLSLRLVKKEPRQLELTWAGSRPRSPGANLTYELHVLNQDEERYQM---VLEPRVLLTEL 506
            ..:.:.:.:.::.:....     :|.||::..:|:   :|.::|...|:..   |...|..|...
  Fly   148 YTAKNEVFINILGERENS-----SGYRPQTSISNV---VHNISQFLPRFDQLPGVQSIRNGLPNS 204

Human   507 QPDTTYIVRVRMLTPLGPGPF-----------------------SPDHEFRTSPPVSRGLT---- 544
            :|...| ..|......||.||                       .||.|...:.||....|
  Fly   205 RPGGWY-PPVPQNNIFGPPPFGNNYPPPPPNIPGVRGEQSGEEEQPDEEVTPTTPVRISSTTPKS 268

Human   545 ---------------------------GGE-------------------IVAVIFGLLLGAALLL 563
                                       ||.                   ||..:.|..:..|:||
  Fly   269 RTKLTPITANNSTRVESAIPAETTTPSGGHHNNSSSPITIFSLKSGTIPIVVTVGGFFVAIAVLL 333

Human   564 GILVFR-----SRR----------AQRQRQQRQRDRATDVDREDKL---WLKP------YVDLQA 604
            ..|..|     ||.          |::..|.:.....||..|...:   |..|      ||..:.
  Fly   334 AYLCRRRLCAISRTLKKTKEKEELAKKSNQSQLSSTLTDDSRNSMVMQQWQGPVAFANRYVPWER 398

Human   605 YED----------------------PAQGALDFTRELDPA------------------------W 623
            .:.                      |:.|..:....|.|.                        |
  Fly   399 DQQMGIATSQLSTGVTNGGVSSPGVPSPGTGEPGSNLGPGCLTGGAGSSGAPENAFAGEANCDRW 463

Human   624 ------LMVDTVIGEGEFGEVYR--GTLRLPSQDCKTVAIKTLKDTSPGGQWWNFLREATIMGQF 680
                  |....::|||.||:|:|  .|....::...|||:||||:::......:.|.|..:|...
  Fly   464 EFPRYRLKFFNILGEGAFGQVWRCEATNINGNEGITTVAVKTLKESATEVDRKDLLSELEVMKSL 528

Human   681 S-HPHILHLEGVVTKRKPIMIITEFMENGALDAFLRE------------REDQLVPGQLVAMLQG 732
            . |.:::||.|..|.:.|..:|.|::..|.|..:||.            :.:.|....|.:.:..
  Fly   529 EPHINVVHLLGCCTDKDPTFVILEYVNRGKLQTYLRSSRAERHYGNTHGKSNVLTSCDLTSFMYQ 593

Human   733 IASGMNYLSNHNYVHRDLAARNILVNQNLCCKVSDFGLTRLLDDF--DGTYETQG-GKIPIRWTA 794
            :|.||:||::...:||||||||||:..:..|||:|||..|   |.  ...||.:. ||:||||.|
  Fly   594 VAKGMDYLTSRGIIHRDLAARNILITDDHTCKVADFGFAR---DVITSKIYERKSEGKLPIRWMA 655

Human   795 PEAIAHRIFTTASDVWSFGIVMWEVLSFGDKPYGEMSNQEVMKSIEDGYRLPPPVDCPAPLYELM 859
            .|::...||:..||:|||||:|||:::.|..||..:|..:||:.:.|||||..|..|...||.:|
  Fly   656 TESLYDNIFSVKSDIWSFGILMWEIVTLGSTPYPGISAADVMRKVRDGYRLEKPEHCRRELYNIM 720

Human   860 KNCWAYDRARRPHFQKLQAHLEQLLANPHSLRTIANFDPRMTLRLPSLSG 909
            ..||::|...||.|.::...|::||........:..|.......:.||||
  Fly   721 YYCWSHDPQERPLFAEIIQMLDKLLHTEMDYIELERFPDHNYYNIVSLSG 770

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EPHA1	NP_005223.4	EphR_LBD_A1	27..203	CDD:198447
		fn3	334..431	CDD:394996	11/44 (25%)
		FN3	453..535	CDD:238020	20/107 (19%)
		EphA2_TM	<586..621	CDD:464211	10/65 (15%)
		Protein Kinases, catalytic domain	619..884	CDD:473864	104/312 (33%)
		SAM_EPH-A1	912..974	CDD:188941
		PDZ-binding. /evidence=ECO:0000255	974..976
Cad96Ca	NP_651349.1	Cadherin_repeat	65..164	CDD:206637	15/80 (19%)
		PTKc	474..742	CDD:270623	99/270 (37%)