DRSC/TRiP Functional Genomics Resources

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Protein Alignment EPHA1 and InR

DIOPT Version :10

Sequence 1:NP_005223.4 Gene:EPHA1 / 2041 HGNCID:3385 Length:976 Species:Homo sapiens
Sequence 2:NP_524436.2 Gene:InR / 42549 FlyBaseID:FBgn0283499 Length:2144 Species:Drosophila melanogaster


Alignment Length:468 Identity:138/468 - (29%)
Similarity:226/468 - (48%) Gaps:79/468 - (16%)


- Green bases have known domain annotations that are detailed below.


Human   463 LELTWAGSRPRSP-GANLTYE----LHVLNQDEER-------YQMVLEPRVLLTELQPDTTYIVR 515
            :.:.|  :.|..| |..:|||    |...:|.||:       :.......:.|.|    ..|..|
  Fly  1224 VRVRW--TPPVDPNGEIVTYEVAYKLQKPDQVEEKKCIPAADFNQTAGYLIKLNE----GLYSFR 1282

Human   516 VRMLTPLGPGPFSPDHEFRTSPPVSRGLTGGEIVAVIFGLLLGAAL------LLGILVFRSRRAQ 574
            ||..:..|.|.|:.....:..||.|        .|.:|..|||..|      |.|.:.:..:|  
  Fly  1283 VRANSIAGYGDFTEVEHIKVEPPPS--------YAKVFFWLLGIGLAFLIVSLFGYVCYLHKR-- 1337

Human   575 RQRQQRQRDRATDVDREDKLWLKP-YVDLQAYEDPAQGALDFTRELDPAWLMVDTVIGEGEFGEV 638
                     :....|......:.| |..:|...|..:...:...:|.|        :|:|.||.|
  Fly  1338 ---------KVPSNDLHMNTEVNPFYASMQYIPDDWEVLRENIIQLAP--------LGQGSFGMV 1385

Human   639 YRGTLRL--PSQDCKTVAIKTLKDTSPGGQWWNFLREATIMGQFSHPHILHLEGVVTKRKPIMII 701
            |.|.|:.  |:...:..||||:.:.:...:..|||.||::|.:|...|::.|.||.::.:|.:::
  Fly  1386 YEGILKSFPPNGVDRECAIKTVNENATDRERTNFLSEASVMKEFDTYHVVRLLGVCSRGQPALVV 1450

Human   702 TEFMENGALDAFLR-----EREDQLVP----------------GQLVAMLQGIASGMNYLSNHNY 745
            .|.|:.|.|.::||     ||::.::.                |::..|...||.||.||:...:
  Fly  1451 MELMKKGDLKSYLRAHRPEERDEAMMTYLNRIGVTGNVQPPTYGRIYQMAIEIADGMAYLAAKKF 1515

Human   746 VHRDLAARNILVNQNLCCKVSDFGLTRLLDDFDGTYETQG--GKIPIRWTAPEAIAHRIFTTASD 808
            |||||||||.:|..:|..|:.|||:||  |.::..|..:|  |.:|:||..||::...::::|||
  Fly  1516 VHRDLAARNCMVADDLTVKIGDFGMTR--DIYETDYYRKGTKGLLPVRWMPPESLRDGVYSSASD 1578

Human   809 VWSFGIVMWEVLSFGDKPYGEMSNQEVMKSIEDGYRLPPPVDCPAPLYELMKNCWAYDRARRPHF 873
            |:|||:|:||:.:...:||..:||::|::.:.||..:..|.:||..|::||:.||.:..:.||.|
  Fly  1579 VFSFGVVLWEMATLAAQPYQGLSNEQVLRYVIDGGVMERPENCPDFLHKLMQRCWHHRSSARPSF 1643

Human   874 QKLQAHLEQLLAN 886
            ..:.|:||....|
  Fly  1644 LDIIAYLEPQCPN 1656

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EPHA1NP_005223.4 EphR_LBD_A1 27..203 CDD:198447
fn3 334..431 CDD:394996
FN3 453..535 CDD:238020 20/83 (24%)
EphA2_TM <586..621 CDD:464211 6/35 (17%)
Protein Kinases, catalytic domain 619..884 CDD:473864 100/289 (35%)
SAM_EPH-A1 912..974 CDD:188941
PDZ-binding. /evidence=ECO:0000255 974..976
InRNP_524436.2 Recep_L_domain 356..465 CDD:460032
Furin-like 510..645 CDD:395614
Recep_L_domain 663..781 CDD:460032
FN3 791..>964 CDD:442628
FN3 1224..1302 CDD:238020 20/83 (24%)
PTKc_InsR_like 1364..1652 CDD:173625 99/297 (33%)
Blue background indicates that the domain is not in the aligned region.

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