DRSC/TRiP Functional Genomics Resources

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Protein Alignment EPHA1 and Egfr

DIOPT Version :10

Sequence 1:NP_005223.4 Gene:EPHA1 / 2041 HGNCID:3385 Length:976 Species:Homo sapiens
Sequence 2:NP_476759.1 Gene:Egfr / 37455 FlyBaseID:FBgn0003731 Length:1426 Species:Drosophila melanogaster


Alignment Length:879 Identity:219/879 - (24%)
Similarity:333/879 - (37%) Gaps:228/879 - (25%)


- Green bases have known domain annotations that are detailed below.


Human   123 NLLYMESDQDV-GIQLRRPLFQKVTTVAAD----QSFTIRDLVSGSVKLNVERCSLGRLTRRGLY 182
            ||.|..:.:.: |.||...:|..:..|.:.    :...::.:.||||.:.               
  Fly   482 NLSYFRNLETIHGRQLMESMFAALAIVKSSLYSLEMRNLKQISSGSVVIQ--------------- 531

Human   183 LAFHNPGACVALVSVR-VFYQRCPET---LNGLAQFPDTLPGPAGLVEVAGTCLPHARASPRPSG 243
               ||...|. :.::| ...|:.||.   :|...:        |.|.|..||....         
  Fly   532 ---HNRDLCY-VSNIRWPAIQKEPEQKVWVNENLR--------ADLCEKNGTICSD--------- 575

Human   244 APRMHCSPDGEWLVPVGRCHCEPGYEEGGSGEACVA-CP--SGSYRMDMDTPHCLTC-PQQSTAE 304
                .|:.||.|.....:|.....:...|:   |:| |.  |.:|:.|..|  |..| |:..|..
  Fly   576 ----QCNEDGCWGAGTDQCLTCKNFNFNGT---CIADCGYISNAYKFDNRT--CKICHPECRTCN 631

Human   305 SEGATIC-------------------------TCESGHYRAPGEGPQVACTGPPS-------APR 337
            ..||..|                         .|...|....|      ||||..       ...
  Fly   632 GAGADHCQECVHVRDGQHCVSECPKNKYNDRGVCRECHATCDG------CTGPKDTIGIGACTTC 690

Human   338 NLSF---SASGTQLSLR---------WE--PPADTGGRQDVRYSVRCSQCQGTAQ----DGGPCQ 384
            ||:.   .|:..:..|:         ||  .|.:.|..:.:.....|.:|....:    .|...|
  Fly   691 NLAIINNDATVKRCLLKDDKCPDGYFWEYVHPQEQGSLKPLAGRAVCRKCHPLCELCTNYGYHEQ 755

Human   385 PCGVGVHFSPGARGLT-TPAVHVNGLEPYANYTFNVEAQNGVSGLGS-------------SGHAS 435
            .|....|:....:..| .||.|....|....:..:.|. ||.:|.|:             :....
  Fly   756 VCSKCTHYKRREQCETECPADHYTDEEQRECFQCHPEC-NGCTGPGADDCKSCRNFKLFDANETG 819

Human   436 TSVSISMGHAESLSGLSLRLVKKEPRQLELTWAGSRPRSPGANLTYELHVLNQDEERYQMVLEPR 500
            ..|:.:|.:..|...|.:|                             ||      .||      
  Fly   820 PYVNSTMFNCTSKCPLEMR-----------------------------HV------NYQ------ 843

Human   501 VLLTELQPDTTYIVRVRMLTPLGPGPFSPDHEFRTSPPVSRGLTGGEIVAVIFGLLLGAAL---- 561
                              .|.:||       ....|||.|..:|....|.:|| ::.||.|    
  Fly   844 ------------------YTAIGP-------YCAASPPRSSKITANLDVNMIF-IITGAVLVPTI 882

Human   562 -LLGILVFRSRRAQRQRQQRQRDRATDVDREDKLWLKPYVDLQAYED-----PAQ-GA-LDFTRE 618
             :|.::.:..|:.|:.:::.               :|..:.|...||     |:. || |...|.
  Fly   883 CILCVVTYICRQKQKAKKET---------------VKMTMALSGCEDSEPLRPSNIGANLCKLRI 932

Human   619 LDPAWLMVDTVIGEGEFGEVYRGTLRLPSQDCK-TVAIKTLKDTSPGGQWWNFLREATIMGQFSH 682
            :..|.|....|:|.|.||.||:|......::.| .||||.|..::.......|||||.||....|
  Fly   933 VKDAELRKGGVLGMGAFGRVYKGVWVPEGENVKIPVAIKELLKSTGAESSEEFLREAYIMASVEH 997

Human   683 PHILHLEGVVTKRKPIMIITEFMENGALDAFLREREDQLVPGQLVAMLQGIASGMNYLSNHNYVH 747
            .::|.|..|....: :|:||:.|..|.|..::|...|::....|:.....||.||:||.....||
  Fly   998 VNLLKLLAVCMSSQ-MMLITQLMPLGCLLDYVRNNRDKIGSKALLNWSTQIAKGMSYLEEKRLVH 1061

Human   748 RDLAARNILVNQNLCCKVSDFGLTRLLDDFDGTYETQGGKIPIRWTAPEAIAHRIFTTASDVWSF 812
            |||||||:||......|::||||.:||......|:..|||:||:|.|.|.|.:|:||:.||||:|
  Fly  1062 RDLAARNVLVQTPSLVKITDFGLAKLLSSDSNEYKAAGGKMPIKWLALECIRNRVFTSKSDVWAF 1126

Human   813 GIVMWEVLSFGDKPYGEMSNQEVMKSIEDGYRLPPPVDCPAPLYELMKNCWAYDRARRPHFQKLQ 877
            |:.:||:|:||.:|:..:..:::...||.|.:|..|..|...:|..:.:||..|.|.||.|::|.
  Fly  1127 GVTIWELLTFGQRPHENIPAKDIPDLIEVGLKLEQPEICSLDIYCTLLSCWHLDAAMRPTFKQLT 1191

Human   878 AHLEQLLANPHSLRTIANFDPRMTLRLPSLSGSD 911
            ....:...:|.  |.:|....:.| |||:.:..|
  Fly  1192 TVFAEFARDPG--RYLAIPGDKFT-RLPAYTSQD 1222

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EPHA1NP_005223.4 EphR_LBD_A1 27..203 CDD:198447 16/85 (19%)
fn3 334..431 CDD:394996 24/135 (18%)
FN3 453..535 CDD:238020 8/81 (10%)
EphA2_TM <586..621 CDD:464211 9/41 (22%)
Protein Kinases, catalytic domain 619..884 CDD:473864 100/265 (38%)
SAM_EPH-A1 912..974 CDD:188941 219/879 (25%)
PDZ-binding. /evidence=ECO:0000255 974..976
EgfrNP_476759.1 Recep_L_domain 128..239 CDD:460032
Furin-like 253..401 CDD:395614
Recep_L_domain 419..547 CDD:460032 16/83 (19%)
GF_recep_IV 572..684 CDD:464344 27/135 (20%)
FU 662..716 CDD:214589 11/59 (19%)
GF_recep_IV 740..>834 CDD:464344 18/94 (19%)
PTKc_EGFR_like 930..1208 CDD:270648 104/280 (37%)
Blue background indicates that the domain is not in the aligned region.

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