DRSC/TRiP Functional Genomics Resources

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Protein Alignment EPHA1 and dnt

DIOPT Version :10

Sequence 1:NP_005223.4 Gene:EPHA1 / 2041 HGNCID:3385 Length:976 Species:Homo sapiens
Sequence 2:NP_477341.2 Gene:dnt / 35207 FlyBaseID:FBgn0024245 Length:584 Species:Drosophila melanogaster


Alignment Length:590 Identity:140/590 - (23%)
Similarity:238/590 - (40%) Gaps:151/590 - (25%)


- Green bases have known domain annotations that are detailed below.


Human   343 ASGTQLSLRWEPPADTGGRQDVRYSVRCSQCQGTAQDGGPCQPCGVGVHFSPGARGLTTPAVHV- 406
            |:...:|..|:..|..|    :.||:..                     .|.....|..||::| 
  Fly    87 ANVKDISFTWQSLAGRG----LPYSINV---------------------VSSDQEVLPRPAINVS 126

Human   407 -NGLEPYANYTFNVEAQNGVSGLGSSGHASTSVSISMGHAESLSGLSLRLVKKEPRQLELTWAGS 470
             :|..|....|:::..:  .||| .:.....:||:.:....||:.::..:.:::           
  Fly   127 HSGEIPTTIQTWSIALK--CSGL-KAAEVDVTVSLEVVLNRSLNNVTHLVFRRK----------- 177

Human   471 RPRSPGANLTYELHVLNQD-EERYQMVLEPRVLLTELQPDTTYIVRVRMLTPLGPGPFSPDHEFR 534
                       ::.::|.. |:..:.|.:|::|.|.:.|.|..|.                    
  Fly   178 -----------KICLMNDSAEDLSEDVDDPQLLETVMLPPTGLIT-------------------- 211

Human   535 TSPPVSRGLTGGEIVAVIFGLLLGAALLLGILVFRSRRAQRQRQQRQRD----RATDVDREDKLW 595
                    |..|..||      :|:..||.::.:..:.|..:||..|..    |.:...|     
  Fly   212 --------LVVGVSVA------MGSVCLLLMIAYCVKGAANKRQHHQHGGQPMRTSSFQR----- 257

Human   596 LKPYVDLQ------AYEDPA--------------------QGALDFTREL-----DPAWLMVDTV 629
            |..:...|      ||..|:                    |...:..|.:     :...:.:.::
  Fly   258 LNTHPPCQSSMGSAAYMTPSIIAPIHGSSLPRKVPVSVEQQHPEELHRRISELTVERCRVRLSSL 322

Human   630 IGEGEFGEVYRGTLRLPSQDCKTVAIKTLKDTSPGGQWWNFLREATIMGQFSHPHILHLEGVVTK 694
            :.||.||.|||||.    .|.:.|.:||:...:...|....|:|..::...|||.||.:.||..:
  Fly   323 LQEGTFGRVYRGTY----NDTQDVLVKTVAQHASQMQVLLLLQEGMLLYGASHPGILSVLGVSIE 383

Human   695 --RKPIMIITEFMENGALDAFLREREDQLVPG--------QLVAMLQGIASGMNYLSNHNYVHRD 749
              ..|.::.........|..||      |.|.        |:|.|...::..:::|.:|..||:|
  Fly   384 DHTTPFVLYPALNNTRNLKQFL------LDPACARTVTTIQIVMMASQLSMALDHLHSHGVVHKD 442

Human   750 LAARNILVNQNLCCKVSDFGLTRLLDDFDGTYETQGG--KIPIRWTAPEAIAHRIFTTASDVWSF 812
            :|.||.:::..|..|:||..|:|  |.|...|...|.  ..|::|.:.||:.|:.|:.|||.|:|
  Fly   443 IATRNCVIDDQLRVKLSDSSLSR--DLFPSDYNCLGDSENRPVKWMSLEALQHKQFSEASDSWAF 505

Human   813 GIVMWEVLSFGDKPYGEMSNQEVMKSIEDGYRLPPPVDCPAPLYELMKNCWAYDRARRPHFQKLQ 877
            |::|||:.:...:||.|:...|:...::|||||..|.:||..|:.:|..|||...|.||.|.:||
  Fly   506 GVLMWELCTSAKQPYAEVDPFEMEHYLKDGYRLAQPFNCPDELFTIMAYCWALLPAERPTFAQLQ 570

Human   878 AHLEQ 882
            :.|.:
  Fly   571 SCLSE 575

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EPHA1NP_005223.4 EphR_LBD_A1 27..203 CDD:198447
fn3 334..431 CDD:394996 18/89 (20%)
FN3 453..535 CDD:238020 9/82 (11%)
EphA2_TM <586..621 CDD:464211 8/65 (12%)
Protein Kinases, catalytic domain 619..884 CDD:473864 89/281 (32%)
SAM_EPH-A1 912..974 CDD:188941
PDZ-binding. /evidence=ECO:0000255 974..976
dntNP_477341.2 WIF 46..182 CDD:128745 22/144 (15%)
Protein Kinases, catalytic domain 310..580 CDD:473864 89/278 (32%)
Blue background indicates that the domain is not in the aligned region.

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