Protein Alignment EPHA1 and Pvr

DIOPT Version :10

• Sequence 1: NP_005223.4
• Gene: EPHA1 / 2041
• HGNCID: 3385
• Length: 976
• Species: Homo sapiens
• Sequence 2: NP_001162911.1
• Gene: Pvr / 34127
• FlyBaseID: FBgn0032006
• Length: 1577
• Species: Drosophila melanogaster
• Alignment Length: 829
• Identity: 181/829 - (21%)
• Similarity: 290/829 - (34%)
• Gaps: 293/829 - (35%)

Human   292 PHCLTCPQQSTAE-----------------SEGATICTCESGHYRAPGEGPQVACTGPPSAPRNL 339
            |..|||..|:..:                 ||..||...:..|..|..:.....|..       |
  Fly   624 PGILTCIAQNIIDGKERRTLTKAHVLLGNISENMTIYGFDKDHKIAKEDNVNFTCEA-------L 681

Human   340 SFSASGTQLSLRWEPPADTGGRQD--------VRYSVRCSQCQGTAQDGGPCQPCGVGVH---FS 393
            ::...|   :|:|....:.....|        .:||.:.:                  ||   .|
  Fly   682 AYHFDG---NLKWFINGEDLKESDSVHIETSHTKYSYKST------------------VHITTIS 725

Human   394 PGARG-LTTPAVHVNGLEPYAN-----YTFNVEAQNGVSGLGSSGHASTSVSISMGHAESLSGLS 452
            ...|| ....|.|.:....|::     |..:..|....:| |..||:
  Fly   726 DRDRGTYECRAYHNDKDAVYSSREIDLYVHDPSAPQWTNG-GQEGHS------------------ 771

Human   453 LRLVKKEPRQLELTWAGSRPRSPGANLTYELHVLNQDEE------RYQMVLEPRVLLTELQP--D 509
             ::.:|..:.|||..|.:  ..|.|.:.:    ...|:|      |:.:..|.::|:|.|.|  :
  Fly   772 -KIKRKLSQTLELECAST--AVPVAIVRW----FKDDKEVTESKLRHIIEKESKLLITHLYPGDE 829

Human   510 TTY--IVRVRMLTPLGPGPFSPDHEFRTSPPVSRGLTGGEIVAVIFGLLLGAALLLGILVFRSRR 572
            ..|  :|..|:           |...|:...|...|.|..:..|.||::| ..:|:|:.||.:.|
  Fly   830 GVYKCVVENRL-----------DRIERSFTVVISDLPGISMAWVWFGVIL-FLILIGLCVFLAVR 882

Human   573 AQRQRQQRQRDRAT---------------DVDREDKLWLKPYVDLQAYEDPAQGALDFTRELDPA 622
            .|::.::....:|.               |:..:::..|.||          ....:|.||.
  Fly   883 YQKEHKRHLALKAAGLANFEEGAVGHINPDLTLDEQAELLPY----------NREFEFPREN--- 934

Human   623 WLMVDTVIGEGEFGEVYRGTLR--LPSQDCKTVAIKTLKDTSPGGQWWNFLREATIM---GQFSH 682
             |.:...:|.|.||.|.:|..:  ...:...|||:|.:|.|:........:.|..||   ||  |
  Fly   935 -LKLGKQLGAGAFGVVLKGEAKGIRREEPTTTVAVKMVKATADNEVVRALVSELKIMVHLGQ--H 996

Human   683 PHILHLEGVVTK---RKPIMIITEFMENGALDAF-LRER-------------------------- 717
            .::::|.|.|||   ::.:|:|.|:...|.:..| ||.|
  Fly   997 LNVVNLLGAVTKNIAKRELMVIVEYCRFGNIQNFLLRNRKCFINQINPDTDHIDPSIMTQRMSDN 1061

Human   718 ----------------------------------------------------------------- 717
                                                                             
  Fly  1062 YELHRDTNGGGLKYANVGFPIHSYINEPHNNNTQPPTHRRNSDNDPRSGTRAGRTGSGTATYSYD 1126

Human   718 ---------------EDQLVPG------------------------QLVAMLQGIASGMNYLSNH 743
                           :||::..                        .|::....:|.||:|||:.
  Fly  1127 RQMDTCATVMTTVPEDDQIMSNNSVQPAWRSNYKTDSTEAMTVTTVDLISWAFQVARGMDYLSSK 1191

Human   744 NYVHRDLAARNILVNQNLCCKVSDFGLTRLLDDFDGTYETQGGKIPIRWTAPEAIAHRIFTTASD 808
            ..:|.||||||||:.::...|:.||||.|.:...|...:::.||:||:|.|.|:::..:|:|.||
  Fly  1192 KVLHGDLAARNILLCEDNVVKICDFGLARSMYRGDNYKKSENGKLPIKWLALESLSDHVFSTYSD 1256

Human   809 VWSFGIVMWEVLSFGDKPY-GEMSNQEVMKSIEDGYRLPPPVDCPAPLYELMKNCWAYDRARRPH 872
            |||:|||:||:.|....|| |...|||:...:.||||:..|......|||:|..||..:...||.
  Fly  1257 VWSYGIVLWEMFSLAKVPYPGIDPNQELFNKLNDGYRMEKPKFANQELYEIMLECWRKNPESRPL 1321

Human   873 FQKLQAHLEQLLA-----------NPHSLRTIANFDPRMTLRLPSLSGS 910
            |.:|:.....:|.           ||:....|.....:.|..| :|.||
  Fly  1322 FAELEKRFANMLGEDVASHYLDLNNPYMQSNIEYMKKQSTDYL-ALMGS 1369

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EPHA1	NP_005223.4	EphR_LBD_A1	27..203	CDD:198447
		fn3	334..431	CDD:394996	19/113 (17%)
		FN3	453..535	CDD:238020	19/91 (21%)
		EphA2_TM	<586..621	CDD:464211	7/49 (14%)
		Protein Kinases, catalytic domain	619..884	CDD:473864	98/404 (24%)
		SAM_EPH-A1	912..974	CDD:188941
		PDZ-binding. /evidence=ECO:0000255	974..976
Pvr	NP_001162911.1	IG_like	346..432	CDD:214653
		Ig strand C	363..366	CDD:409353
		Ig strand E	396..400	CDD:409353
		Ig strand F	410..415	CDD:409353
		Ig strand G	425..428	CDD:409353
		Ig	458..533	CDD:472250
		Ig strand B	459..463	CDD:409353
		Ig strand C	472..476	CDD:409353
		Ig strand E	497..503	CDD:409353
		Ig strand F	513..518	CDD:409353
		Ig	671..>742	CDD:472250	15/98 (15%)
		Ig strand B	674..678	CDD:409353	0/3 (0%)
		Ig strand C	687..691	CDD:409353	2/6 (33%)
		Ig strand E	717..721	CDD:409353	1/21 (5%)
		Ig strand F	731..736	CDD:409353	0/4 (0%)
		Ig	779..851	CDD:472250	19/88 (22%)
		Ig strand B	781..785	CDD:409570	3/3 (100%)
		Ig strand C	794..798	CDD:409570	0/7 (0%)
		Ig strand E	816..821	CDD:409570	1/4 (25%)
		Ig strand F	831..836	CDD:409570	1/4 (25%)
		Ig strand G	844..847	CDD:409570	1/2 (50%)
		Protein Kinases, catalytic domain	927..1332	CDD:473864	101/410 (25%)