Protein Alignment EPHA1 and Ddr

DIOPT Version :10

• Sequence 1: NP_005223.4
• Gene: EPHA1 / 2041
• HGNCID: 3385
• Length: 976
• Species: Homo sapiens
• Sequence 2: NP_001014474.3
• Gene: Ddr / 3346209
• FlyBaseID: FBgn0053531
• Length: 1054
• Species: Drosophila melanogaster
• Alignment Length: 995
• Identity: 215/995 - (21%)
• Similarity: 325/995 - (32%)
• Gaps: 394/995 - (39%)

Human    43 LLDPPKDGWSEQQQILNGTPLYMYQDCPMQGRRDTDHWLRS--------NWI-YRGEEASRVHVE 98
            |.|...||:.|....:||....      :.|:|..|::...        .|| :|.:......||
  Fly   285 LSDKTYDGYEEGDHYVNGLGQL------VDGQRGKDNFRADINGLGKGYEWIGWRNDTLLGRPVE 343

Human    99 LQF---TVR---------------DCKSFP--------GGAGPLGCKETFNL---LYMESDQDVG 134
            :.|   |||               |.:.|.        ||....|....|:.   |.::..:||.
  Fly   344 IIFEFETVRNLSAVIIHTNNMFSKDVQVFVHAKVFFSIGGRHFSGEPVQFSYMPDLVLDHARDVT 408

Human   135 IQL----------------RRPLFQKVTTVAADQSFTIRDLVSGSVKLNV------ERCSLGRLT 177
            |:|                |..:..::|.::|.......|.::...|.:|      :|..:||..
  Fly   409 IKLHHRLGRYVQLHLYFAARWMMISEITFISAPVVGNFTDELANGEKQSVTSEYPLQRDEVGRAI 473

Human   178 RRG--------------------------------------LYLAFHNPGACVALVSVRVFYQRC 204
            ..|                                      |.:||      :.|:..|..:.|.
  Fly   474 SSGGERSQHTTQVISPKPIDHQEPETSFVGVIITVLGTIIMLLVAF------ILLIVARNKHVRS 532

Human   205 PETLNGLAQF-----PDTLPGPAGLVEVAGTCLPHARASPRPSGAPRMHCSPDGEWLVPVGRCHC 264
            .|  |||..|     ||||.| .|:::|..|                   ..|.|..:.....:.
  Fly   533 RE--NGLDAFQHNFSPDTLNG-NGVLKVVTT-------------------MDDNESSIDKNSLYH 575

Human   265 EPGYEEGGSGEACVACPSGSYRMDMDTPHCLTCPQQSTAESEGATICTCESGHYRAPGEGPQVAC 329
            || :.......|..|||..    |:...|.                    |..|.   :.|.:.|
  Fly   576 EP-FNANMYTSAASACPMN----DLQRQHV--------------------SPDYT---DVPDIVC 612

Human   330 TGPPSAPRNLSFSASGTQLSLRWEPPADTGGRQDVRYSVRCSQCQGTAQDGGPCQPCGVGVHFSP 394
            .         .::....|..|...||..:|                          ||.|....|
  Fly   613 Q---------DYAVPHMQQLLPNAPPCGSG--------------------------CGTGTGTGP 642

Human   395 GARGLTTPAVHVNGLEPYANYTFNVEAQNGVSGLGSSGHASTSVSISMGHAESLSGLSLRLVKKE 459
            | ||.:...|...|                              .::.....||:..:|.|....
  Fly   643 G-RGSSPEFVVATG------------------------------KVTASARNSLNAATLPLPSPP 676

Human   460 -PRQLELTWA----GSRP---RSPGANLTYELHVLNQDEERYQMVLEPRVLLTELQPDTTYIVRV 516
             |..||..:|    .|:|   ..||:..:                       ..|...||
  Fly   677 VPPPLEKYYAATPVSSKPMPVAPPGSQSS-----------------------GSLSSSTT----- 713

Human   517 RMLTP----LGPGPFSPDHEFRTSPPVSRGLTGGEIVAVIFGLLLGAALLLGILVFRSRRAQRQR 577
            ...||    :|.|  .|.|                     :.|.:.|
  Fly   714 AATTPTSGVVGVG--KPHH---------------------YNLDMSA------------------ 737

Human   578 QQRQRDRATDVDREDKLWLKPYVDLQAYEDPAQGALDFTRELDPAWLMVDTVIGEGEFGEVYRGT 642
                  ...|::.|       ..:.|..|.|.|.            |::...:|.|.|||::.
  Fly   738 ------NFADINEE-------RANCQVQEFPRQS------------LVIVEKLGSGVFGELHL-- 775

Human   643 LRLPSQDCKT-------VAIKTLKDTSPGGQWWNFLR-----EATIMGQFSHPHILHLEGVVTKR 695
                   |:|       ||:.||:   ||..  :.||     :|..:.|.|.|::..|.|...:.
  Fly   776 -------CETNVLNATLVAVATLR---PGAN--DHLRKEFRSKAKQLAQLSDPNVARLVGACLRD 828

Human   696 KPIMIITEFME-NGALDAFLRER---------EDQLVPGQLVAMLQGIASGMNYLSNHNYVHRDL 750
            :||.|:.::.. .|.|:.||:|.         :..|..|.||.:...|||||.:|...|:|||||
  Fly   829 EPICIVQDYSHCLGDLNQFLQEHVAETSGLMAKKSLSFGCLVYIATQIASGMKHLEQMNFVHRDL 893

Human   751 AARNILVNQNLCCKVSDFG--LTR--------LLDDFDGTYETQGGKIPIRWTAPEAIAHRIFTT 805
            |.|:.::...||.||...|  :.|        .|:.|.|   .|...:||||.|.|::....|||
  Fly   894 ATRSCIIGPELCVKVCSIGTVINRSAYASDYCQLEGFTG---RQSQPMPIRWMAWESVLLGKFTT 955

Human   806 ASDVWSFGIVMWEVLSFG-DKPYGEMSNQEVMKSIEDGYR-------LPPPVDCPAPLYELMKNC 862
            .||||||.:.:||:|:|. ::||..:|::.|:::|...||       ||.|.:||..:|:||..|
  Fly   956 KSDVWSFAVALWEILTFAREQPYEHLSDKSVIENIGLIYRDYKMHELLPMPPNCPREIYDLMCEC 1020

Human   863 WAYDRARRPHFQKLQAHLEQ 882
            |..|.:.||.|:::..:|::
  Fly  1021 WQRDESSRPSFREIHLYLQR 1040

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EPHA1	NP_005223.4	EphR_LBD_A1	27..203	CDD:198447	45/257 (18%)
		fn3	334..431	CDD:394996	14/96 (15%)
		FN3	453..535	CDD:238020	19/93 (20%)
		EphA2_TM	<586..621	CDD:464211	6/34 (18%)
		Protein Kinases, catalytic domain	619..884	CDD:473864	99/304 (33%)
		SAM_EPH-A1	912..974	CDD:188941
		PDZ-binding. /evidence=ECO:0000255	974..976
Ddr	NP_001014474.3	FA58C	109..261	CDD:238014
		PTKc_DDR	753..1040	CDD:270644	102/315 (32%)