Protein Alignment STOM and CG42540

DIOPT Version :10

• Sequence 1: NP_004090.4
• Gene: STOM / 2040
• HGNCID: 3383
• Length: 288
• Species: Homo sapiens
• Sequence 2: NP_001246627.1
• Gene: CG42540 / 38562
• FlyBaseID: FBgn0260657
• Length: 517
• Species: Drosophila melanogaster
• Alignment Length: 281
• Identity: 183/281 - (65%)
• Similarity: 228/281 - (81%)
• Gaps: 12/281 - (4%)

Human     2 AEKRHTRDSEAQR------LPDSFKDSPSKGLGPCGWILVAFSFLFTVITFPISIWMCIKIIKEY 60
            ||.|  ||::|:.      ..:...|..|    .||.:|:..|....::|.|.|:::|.|:::||
  Fly   158 AEAR--RDTQAKHSHGFLYSDEEISDKAS----TCGKLLIFLSVALVIMTLPFSLFVCFKVVQEY 216

Human    61 ERAIIFRLGRILQGGAKGPGLFFILPCTDSFIKVDMRTISFDIPPQEILTKDSVTISVDGVVYYR 125
            |||:||||||::||||||||:||||||.||:.:||:||.::|:||||:|||||||:|||.|||||
  Fly   217 ERAVIFRLGRLMQGGAKGPGIFFILPCIDSYARVDLRTRTYDVPPQEVLTKDSVTVSVDAVVYYR 281

Human   126 VQNATLAVANITNADSATRLLAQTTLRNVLGTKNLSQILSDREEIAHNMQSTLDDATDAWGIKVE 190
            |.|||:::||:.||..:|||||||||||.:||::|.:|||:|..|:..||..||:||||||||||
  Fly   282 VSNATVSIANVENAHHSTRLLAQTTLRNTMGTRHLHEILSERMTISGTMQVQLDEATDAWGIKVE 346

Human   191 RVEIKDVKLPVQLQRAMAAEAEASREARAKVIAAEGEMNASRALKEASMVITESPAALQLRYLQT 255
            |||||||:|||||||||||||||:|||||||||||||..|||||:|||.||.:||||||||||||
  Fly   347 RVEIKDVRLPVQLQRAMAAEAEAAREARAKVIAAEGEQKASRALREASEVIGDSPAALQLRYLQT 411

Human   256 LTTIAAEKNSTIVFPLPIDML 276
            |.||:||||||||||||||::
  Fly   412 LNTISAEKNSTIVFPLPIDLI 432

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
STOM	NP_004090.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..22		6/25 (24%)
		SPFH_stomatin	73..274	CDD:259801	153/200 (77%)
		Required for homooligomerization	265..273		7/7 (100%)
		Required for lipid raft association	267..269		1/1 (100%)
		Interaction with LANCL1. /evidence=ECO:0000269|PubMed:9512664	273..287		2/4 (50%)
CG42540	NP_001246627.1	SPFH_stomatin	229..430	CDD:259801	153/200 (77%)