Protein Alignment STOM and CG33253

DIOPT Version :10

• Sequence 1: NP_004090.4
• Gene: STOM / 2040
• HGNCID: 3383
• Length: 288
• Species: Homo sapiens
• Sequence 2: NP_001259699.1
• Gene: CG33253 / 2768889
• FlyBaseID: FBgn0030992
• Length: 414
• Species: Drosophila melanogaster
• Alignment Length: 289
• Identity: 166/289 - (57%)
• Similarity: 219/289 - (75%)
• Gaps: 8/289 - (2%)

Human     5 RHTRDSEAQRLP-------DSFKDSPSKGLGPCGWILVAFSFLFTVITFPISIWMCIKIIKEYER 62
            :|.....|..:|       ...|.|.:..:|....:....|.|..|:|||||:::|.|::.||||
  Fly    37 QHQSSQHAVHIPPPPSLPYQGLKTSENDDMGCVEILATVVSVLIMVLTFPISVFICFKVVSEYER 101

Human    63 AIIFRLGRILQGGAKGPGLFFILPCTDSFIKVDMRTISFDIPPQEILTKDSVTISVDGVVYYRVQ 127
            |:|||:||:..|||:|||:||:|||.|.:..||:||:|||:||||:|:|||||::||.|||||:.
  Fly   102 AVIFRMGRLRSGGARGPGVFFVLPCVDDYYPVDLRTVSFDVPPQEVLSKDSVTVTVDAVVYYRIS 166

Human   128 NATLAVANITNADSATRLLAQTTLRNVLGTKNLSQILSDREEIAHNMQSTLDDATDAWGIKVERV 192
            :...||..:.|...:|.|||.|||||||||:|||::|::||.|:|.||.:||:|||.||:|||||
  Fly   167 DPLKAVIQVYNYSHSTSLLAATTLRNVLGTRNLSELLTERETISHTMQMSLDEATDPWGVKVERV 231

Human   193 EIKDVKLPVQLQRAMAAEAEASREARAKVIAAEGEMNASRALKEASMVITESPAALQLRYLQTLT 257
            |||||.||..|||||||||||:||||||||||||||.:||||:|||.:|:.||:||||||||||:
  Fly   232 EIKDVSLPTALQRAMAAEAEAAREARAKVIAAEGEMKSSRALREASEIISASPSALQLRYLQTLS 296

Human   258 TIAAEKNSTIVFPLPIDMLQGIIGAK-HS 285
            :|:.||||||:||||:::|...:..: ||
  Fly   297 SISTEKNSTIIFPLPMELLTPFLNTQAHS 325

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
STOM	NP_004090.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..22		4/23 (17%)
		SPFH_stomatin	73..274	CDD:259801	137/200 (69%)
		Required for homooligomerization	265..273		6/7 (86%)
		Required for lipid raft association	267..269		1/1 (100%)
		Interaction with LANCL1. /evidence=ECO:0000269|PubMed:9512664	273..287		3/14 (21%)
CG33253	NP_001259699.1	SPFH_SLP-4	112..319	CDD:259813	138/206 (67%)