DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sfrp1 and Corin

DIOPT Version :9

Sequence 1:	NP_038862.2	Gene:	Sfrp1 / 20377	MGIID:	892014	Length:	314	Species:	Mus musculus
Sequence 2:	NP_610297.2	Gene:	Corin / 35691	FlyBaseID:	FBgn0033192	Length:	1397	Species:	Drosophila melanogaster

Alignment Length:	325	Identity:	71/325 - (21%)
Similarity:	111/325 - (34%)	Gaps:	90/325 - (27%)

- Green bases have known domain annotations that are detailed below.

Mouse    18 LLALAAALLA-AGSASEYDYVSFQSDIGSYQSGRFYTK-------------------PPQCVDIP 62
            :|..|.|||| ||..:.|        ..:|.:.:|..|                   |..|  :|
  Fly   727 ILINAFALLAIAGGLAAY--------FNAYPTIKFVNKTIINTIHVEDTTSFGKNPAPGTC--LP 781

Mouse    63 VDLRLCH--NVGYKKMVLPNLLEHETMAEVKQQASSWVPLLNKNCHMGTQVFLCSLFAPVC--LD 123
            :.:|.|.  .:.|...|.||.:.|....|.:....|:..|::..|:....:|||:||.|.|  ..
  Fly   782 IIVRFCQGPQIPYNYTVFPNYIGHFGQLETQTDLDSYEALVDVRCYELVSLFLCTLFVPKCGQSG 846

Mouse   124 RPIYPCRWLCEAVRDSCEPVMQFFGFYWPEMLKC---DKFPEGDVCIAMTPPNTTEASKPQGTTV 185
            ..:.||:.||......|......||...||.|.|   ..||..:.|:.:     .|..:......
  Fly   847 ATVPPCKTLCTETMRRCGFFFDVFGLSLPEYLNCKLFKDFPSSEDCVGL-----DEVREVMRAAT 906

Mouse   186 CPPCD------NELKSEAIIEHLCASEFALRMKIKEVKKEN--------GDKKIVPKKKKPLKLG 236
            .|.||      |....:   |::|........:..|.|.|.        ||.:.:..|
  Fly   907 HPKCDGFQCDQNRCLPQ---EYVCDGHLDCMDQADEAKCERCGPDEIYCGDSQCIGTK------- 961

Mouse   237 PIKKKELKRLVLFLKNG-ADCP-------CHQLD----NLSHNFLIMGRKVKSQYLLTAIHKWDK 289
                        .:.:| .|||       |.:|.    ::....|.:.|..:.|::...:..||:
  Fly   962 ------------HICDGIIDCPYGQDERNCLRLSERNGDVGTGVLEVYRIGQRQWMPACVKNWDR 1014

Mouse 290 289
Fly 1015 1014

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sfrp1	NP_038862.2	CRD_SFRP1	52..175	CDD:143552	36/148 (24%)
Sfrp1	NP_038862.2	NTR_Sfrp1_like	183..306	CDD:239635	23/133 (17%)
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549	34/117 (29%)
		LDLa	911..942	CDD:238060	5/33 (15%)
		LDLa	945..979	CDD:238060	7/52 (13%)
		SR	980..>1034	CDD:214555	6/35 (17%)
		SRCR	992..1086	CDD:278931	5/23 (22%)
		Tryp_SPc	1103..1343	CDD:214473
		Tryp_SPc	1104..1346	CDD:238113
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900