Protein Alignment EPB41L2 and Frmd5

DIOPT Version :10

• Sequence 1: NP_001337228.1
• Gene: EPB41L2 / 2037
• HGNCID: 3379
• Length: 1057
• Species: Homo sapiens
• Sequence 2: NP_609384.1
• Gene: Frmd5 / 34398
• FlyBaseID: FBgn0032225
• Length: 572
• Species: Drosophila melanogaster
• Alignment Length: 464
• Identity: 141/464 - (30%)
• Similarity: 222/464 - (47%)
• Gaps: 52/464 - (11%)

Human   219 QCKVTLLDGTE-YSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDPAKEIKRQ 282
            :|.|.|||.:: ..|:.:...||..|.:.:|..|.:.|||||||.:.:|.:|::|||.:|.|.:|
  Fly    13 KCTVRLLDDSDVLECEFQPFHKGIYLLEYLCGELEIKEKDYFGLRYVDSSKQRHWLDLSKSIIKQ 77

Human   283 LRNL-PWLFTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHALLGSYTLQAELG 346
            .:.: |.||:..|||||.||.:||.: .|..|..||::|:..|||.||....|.||:..:|.|||
  Fly    78 CKEMDPLLFSLRVKFYPADPFRLTGN-ARIMLYQQLKRDLRHGRLYCSLGEAAALGALIVQEELG 141

Human   347 DYDPEEHGSIDLSEFQFAPTQTKELEEKVAELHKTHR-GLSPAQADSQFLENAKRLSMYGVDLHH 410
            ||:.:.|....:|..:.|..||:.||:|:.||||... |.:.:.|..:||..|:.|..||:|.|.
  Fly   142 DYNEDVHVGSYVSSIELALRQTECLEKKIIELHKKREPGQNLSLAMDEFLGIARGLETYGIDPHP 206

Human   411 AKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKILKISYKRSNF--YIKVRPAELEQFESTIGF 473
            .||..|....:|:...|:..:....|...|.|.:|.||:::...|  ::....|..|..:.|:||
  Fly   207 VKDHRGSQQYVGINNTGISTFVAGKRSQHFRWNEIHKINFEGKMFIAHLSYTDASREPKKHTVGF 271

Human   474 KLPNHRAAKRLWKVCVEHHTFYRLVSPEQPPKAK---FLTLGSKFRYSGRTQAQ--TRQASTLID 533
            |.|...|.:.||:..:|...|:.|.:.:......   |.:.|:||||:|||:.:  |...:.|.:
  Fly   272 KCPTGAACRYLWRCAIEQMLFFTLPNSQSAAVISGGGFFSWGTKFRYTGRTEREILTENINALRE 336

Human   534 RPAPHFERTSSKRVSRSLDGAPI----------------GVMDQSLMKDFPGAAGEISAYGPGLV 582
            :..   ...||||.:.|:...|.                ..|.:.|....|.  |....:..|:
  Fly   337 QKN---NSNSSKRKASSVPATPSSPQGDLAQIRYSSLPRSTMSEPLGYGMPN--GHFYGHDHGM- 395

Human   583 SIAVVQDGDGRREVRSPTKAPHLQLI--EGKKNSLRVEGDNIYVRHSNLMLEELDKAQEDILKHQ 645
                 .|.:|..::.|      |:.:  |.:..|..::|.|.      |..:....|..|.::|.
  Fly   396 -----SDANGGIQISS------LEPVCEEARLRSSNIDGVNY------LASQIGGYAYRDSVEHS 443

Human   646 ASISELKRN 654
            ::.|.|..|
  Fly   444 STESGLTVN 452

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EPB41L2	NP_001337228.1	PTZ00121	<9..222	CDD:173412	1/2 (50%)
		B41	220..409	CDD:214604	78/191 (41%)
		FERM_C_4_1_family	404..497	CDD:270005	28/94 (30%)
		FA	507..550	CDD:462582	15/47 (32%)
		SAB	630..670	CDD:461285	6/25 (24%)
		4_1_CTD	944..1050	CDD:461774
Frmd5	NP_609384.1	FERM_F1_FRMD3	12..93	CDD:340622	31/79 (39%)
		FERM_M	104..205	CDD:459788	40/100 (40%)
		FERM_C_FRMD3_FRMD5	186..294	CDD:270013	33/107 (31%)
		FA	308..350	CDD:462582	15/44 (34%)