DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment EPB41L2 and Epb41l2

DIOPT Version :9

Sequence 1:	XP_024302117.1	Gene:	EPB41L2 / 2037	HGNCID:	3379	Length:	1079	Species:	Homo sapiens
Sequence 2:	XP_006512569.1	Gene:	Epb41l2 / 13822	MGIID:	103009	Length:	1062	Species:	Mus musculus

Alignment Length:	1081	Identity:	890/1081 - (82%)
Similarity:	954/1081 - (88%)	Gaps:	21/1081 - (1%)

- Green bases have known domain annotations that are detailed below.

Human     1 MTTEVGSVSEVKKDSSQLGTDATKEKPKEVAENQQNQSSDPEEEKGSQPPPAAESQSSLRRQKRE 65
            |||||||.|||||.|.|.|.||:|||.||| ||:|...|:|||||||||.|..|.||:.|.:||.
Mouse     1 MTTEVGSASEVKKGSDQAGADASKEKAKEV-ENEQTPVSEPEEEKGSQPGPPVERQSTPRLRKRG 64

Human    66 KETSESRGISRFIPPWLKKQKSYTLVVAKDGGDKKEPTQAVVEEQVLDKEEPLPEEQRQAKGDAE 130
            |:.||:||||||||||||||:||.||||||||||||||||.||:|:|.|||.||||:.:||||||
Mouse    65 KDPSENRGISRFIPPWLKKQRSYNLVVAKDGGDKKEPTQADVEDQILGKEESLPEEESRAKGDAE 129

Human   131 EMAQKKQ-EIKVEVKEEKPSVSKEEKPSVSKVEMQPTELVSKEREEKVKETQEDKLEGGAAKRET 194
            ||||:|. |::|||:|.||::.       |.||.||.|.|.|::||.:::|||:|||||||||||
Mouse   130 EMAQRKHLEVQVEVREAKPALK-------SSVETQPAEEVRKDKEETIQDTQEEKLEGGAAKRET 187

Human   195 KEVQTNELKAEKASQKVTKKTKTVQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYF 259
            |||||:|||||.||||.|||||||..||||||||||||||||.||||||||:|||||||||||||
Mouse   188 KEVQTSELKAEVASQKATKKTKTVLAKVTLLDGTEYSCDLEKRAKGQVLFDRVCEHLNLLEKDYF 252

Human   260 GLLFQESPEQKNWLDPAKEIKRQLRNLPWLFTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASG 324
            |||||:.|||||||||||||||||:||||||||||||||||||||||||||||||||||||||||
Mouse   253 GLLFQDHPEQKNWLDPAKEIKRQLKNLPWLFTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASG 317

Human   325 RLPCSFVTHALLGSYTLQAELGDYDPEEHGSIDLSEFQFAPTQTKELEEKVAELHKTHRGLSPAQ 389
            ||||||||||||||||||||.|||||||:.||||.:|||||..||||||||:|||||||||||||
Mouse   318 RLPCSFVTHALLGSYTLQAEHGDYDPEEYDSIDLGDFQFAPAHTKELEEKVSELHKTHRGLSPAQ 382

Human   390 ADSQFLENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKILKISYKRSN 454
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   383 ADSQFLENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKILKISYKRSN 447

Human   455 FYIKVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFYRLVSPEQPPKAKFLTLGSKFRYSG 519
            |||||||||||||||||||||||||||||||||||||||||||||||||||.|||||||||||||
Mouse   448 FYIKVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFYRLVSPEQPPKTKFLTLGSKFRYSG 512

Human   520 RTQAQTRQASTLIDRPAPHFERTSSKRVSRSLDGAPIGVMDQSLMKDFPGAAGEISAYGPGLVSI 584
            |||||||:||||||||||.|||.||||||||||||||||:|||       ..||.|..|||::|.
Mouse   513 RTQAQTREASTLIDRPAPQFERASSKRVSRSLDGAPIGVVDQS-------PPGEGSVPGPGVISY 570

Human   585 AVVQDGDGRREVRSPTKAPHLQLIEGKKNSLRVEGDNIYVRHSNLMLEELDKAQEDILKHQASIS 649
            ..:|  ||||:.:|||||..|. .|||||:|||:||||||||||||||:||||||.|||||||||
Mouse   571 TTIQ--DGRRDSKSPTKATPLP-AEGKKNTLRVDGDNIYVRHSNLMLEDLDKAQEAILKHQASIS 632

Human   650 ELKRNFMESTPEPRPNEWEKRRITPLSLQTQGSLEEEITSILFSEKGFSDSMKATFTSATTWTAE 714
            |||||||.|||||||:||||||:|||..|.|.||||||||||||.:|||.|:||:|.||||||||
Mouse   633 ELKRNFMASTPEPRPSEWEKRRVTPLPFQPQASLEEEITSILFSGQGFSLSVKASFPSATTWTAE 697

Human   715 GAVVSANAPSEKLSSSPFSHLLETRAPESEGPCTGARDAVKSSHETLNIVEEKKRAEVGKDERVI 779
            |.||:||||.|.||||||||..|||.|.|||||||.||||||||||||:|||||||||||||.||
Mouse   698 GPVVNANAPREPLSSSPFSHSPETRPPTSEGPCTGPRDAVKSSHETLNVVEEKKRAEVGKDESVI 762

Human   780 TEEMNGKEISPGSGPGEIRKVEPVTQKDSTSLSSESSSSSSESEEEDVGEYRPHHRVTEGTIREE 844
            ||||||||:|||.||||.||||||..||||||||||||||||| |||||||:|||||||||||||
Mouse   763 TEEMNGKEMSPGHGPGETRKVEPVAHKDSTSLSSESSSSSSES-EEDVGEYQPHHRVTEGTIREE 826

Human   845 Q-EYEEEVEEEPRPAAKVVEREEAVPEASPVTQAGASVITVETVIQENVGAQKIPGEKSVHEGAL 908
            | |.:||:||||...|||||||.|||:|.|..||||||:.|||..||:|.|||:||||..|.|..
Mouse   827 QEECDEELEEEPGQGAKVVEREAAVPDAVPDRQAGASVLPVETEAQEHVVAQKLPGEKGAHGGTA 891

Human   909 KQDMGEEAEEEPQKVNGEVSHVDIDVLPQIICCSEPPVVKTEMVTISDASQRTEISTKEVPIVQT 973
            :||..|||||:|.:|||||.|:|:|.||:||||||||||||||||||||||||||||||||||||
Mouse   892 EQDPREEAEEDPHRVNGEVPHLDLDGLPEIICCSEPPVVKTEMVTISDASQRTEISTKEVPIVQT 956

Human   974 ETKTITYESPQIDGGAGGDSGTLLTAQTITSESVSTTTTTHITKTVKGGISETRIEKRIVITGDG 1038
            |||||||||||||||||||||.|||||||||||.||||||||||||||||||||||||||||||.
Mouse   957 ETKTITYESPQIDGGAGGDSGVLLTAQTITSESASTTTTTHITKTVKGGISETRIEKRIVITGDA 1021

Human  1039 DIDHDQALAQAIREAREQHPDMSVTRVVVHKETELAEEGED 1079
            .:||||||||||||||||||||||||||||||||||||||:
Mouse  1022 ALDHDQALAQAIREAREQHPDMSVTRVVVHKETELAEEGEE 1062

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EPB41L2	XP_024302117.1	Neuromodulin_N	<9..222	CDD:331332	145/213 (68%)
		B41	220..409	CDD:214604	174/188 (93%)
		FERM_C_4_1_family	404..497	CDD:270005	92/92 (100%)
		FA	507..549	CDD:312314	38/41 (93%)
		SAB	630..673	CDD:309500	38/42 (90%)
		4_1_CTD	967..1072	CDD:310467	99/104 (95%)
Epb41l2	XP_006512569.1	PTZ00121	<4..209	CDD:173412	145/212 (68%)
		B41	213..402	CDD:214604	174/188 (93%)
		FERM_C_4_1_family	397..490	CDD:270005	92/92 (100%)
		FA	500..543	CDD:400882	39/42 (93%)
		SAB	613..653	CDD:398195	35/39 (90%)
		PHA03247	<642..745	CDD:223021	81/102 (79%)
		4_1_CTD	950..1052	CDD:399118	96/101 (95%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83973581
Domainoid	1	1.000	323	1.000	Domainoid score	I14889
eggNOG	1	0.900	-	-		E1_KOG3530
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37478
Inparanoid	1	1.050	1613	1.000	Inparanoid score	I2574
Isobase	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG43466
OrthoDB	1	1.010	-	-		D104938at7742
OrthoFinder	1	1.000	-	-		FOG0001068
OrthoInspector	1	1.000	-	-		oto119249
orthoMCL	1	0.900	-	-		OOG6_101605
Panther	1	1.100	-	-	LDO	PTHR23280
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R11792
SonicParanoid	1	1.000	-	-		X1151
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	19	19.300