Protein Alignment EPB41L2 and epb41l2

DIOPT Version :9

• Sequence 1: XP_024302117.1
• Gene: EPB41L2 / 2037
• HGNCID: 3379
• Length: 1079
• Species: Homo sapiens
• Sequence 2: XP_031758369.1
• Gene: epb41l2 / 100379759
• XenbaseID: XB-GENE-988171
• Length: 1064
• Species: Xenopus tropicalis
• Alignment Length: 1127
• Identity: 639/1127 - (56%)
• Similarity: 777/1127 - (68%)
• Gaps: 113/1127 - (10%)

Human     1 MTTEVGSVSEVKKDSSQLG-----TDATKEKPKEVAEN--QQNQSSDPEEEKGSQPPPAAESQSS 58
            ||||..|..|: .:|.|.|     |..:.::.|:|.||  |:..::..|.|:...||..:.|...
 Frog     1 MTTETTSGIEL-NNSGQPGDQEEHTGISSKESKKVEENIDQEIVNNPGETEQVIDPPSPSTSAGQ 64

Human    59 LRRQKREKETSESRGISRFIPPWLKKQKSYTLVVAKDGGDKKEPTQAVVEEQVLDKEEPLPEEQR 123
            ....||:||..||:|||||:|||||||||.:.|...:.|||.     ::.|
 Frog    65 QSPGKRQKEIPESKGISRFLPPWLKKQKSQSQVDTNENGDKN-----ILRE-------------- 110

Human   124 QAKGDAEE---MAQKKQEIKVEVKEEKP----SVSKEEKPSVSKVEMQPT-ELVSKEREEKVKET 180
              ||.|||   .:|.|:|:.:..::::|    :..||||.|:| .|:||| |..:.:.::|:.:.
 Frog   111 --KGSAEEGSSPSQIKEEVDIGGEKDQPVAIKADDKEEKRSIS-TEIQPTKEDNNIDDKQKIADE 172

Human   181 QEDKLEGGAAKRETKEVQTNELKAEKASQKVTKKTKTVQCKVTLLDGTEYSCDLEKHAKGQVLFD 245
            :|:|.||   :::|::.|..|  .:|...|..||.|||.|||.||||||||||:||.||||.|:.
 Frog   173 KEEKQEG---EKDTRDAQHTE--GKKILHKTPKKMKTVMCKVKLLDGTEYSCDIEKRAKGQALYA 232

Human   246 KVCEHLNLLEKDYFGLLFQESPEQKNWLDPAKEIKRQLRNLPWLFTFNVKFYPPDPSQLTEDITR 310
            .|.|||||||.|||||..|:|..|||||||.||||||:|..||||.|:|||||||||||:||:||
 Frog   233 NVYEHLNLLETDYFGLTCQDSAYQKNWLDPTKEIKRQVRRTPWLFVFSVKFYPPDPSQLSEDLTR 297

Human   311 YFLCLQLRQDIASGRLPCSFVTHALLGSYTLQAELGDYDPEEHGSIDLSEFQFAPTQTKELEEKV 375
            |.||||||||::||||||||.||.:|||||||||||||:..||....:|.|||||.||||:|:|:
 Frog   298 YLLCLQLRQDVSSGRLPCSFATHTILGSYTLQAELGDYETSEHSDDYISGFQFAPNQTKEMEDKI 362

Human   376 AELHKTHRGLSPAQADSQFLENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINRF 440
            .|||||||||:||||:.|||||||:|||||||||:|||||||||.||||:|||||||||||||||
 Frog   363 VELHKTHRGLTPAQAELQFLENAKKLSMYGVDLHYAKDSEGVDIMLGVCSNGLLIYKDRLRINRF 427

Human   441 AWPKILKISYKRSNFYIKVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFYRLVSPEQPPK 505
            |||||||||||||||||||||.|:||||||||||||.|||||||||||||||||:||.||.||||
 Frog   428 AWPKILKISYKRSNFYIKVRPGEMEQFESTIGFKLPTHRAAKRLWKVCVEHHTFFRLSSPAQPPK 492

Human   506 AKFLTLGSKFRYSGRTQAQTRQASTLIDRPAPHFERTSSKRVSRSLDGAPI-GVMDQSLMKDFPG 569
            |||||||||||||||||||||:||..||||||:|||||||||||||||||| |..||||:||:..
 Frog   493 AKFLTLGSKFRYSGRTQAQTREASIKIDRPAPYFERTSSKRVSRSLDGAPIGGTTDQSLLKDYSY 557

Human   570 AAGEISAYGPGLVSIAVVQDGDGRREVRSPTKAPHLQL---------------IEGKKNSLRVEG 619
            ...:.:..|........:|:|   .|| ||.|:....|               .|.:.||||:||
 Frog   558 TKADNAVDGIVKAQEKAIQEG---AEV-SPAKSAQFLLQKDTKSLMKEEEDEEQEKQSNSLRIEG 618

Human   620 DNIYVRHSNLMLEELDKAQEDILKHQASISELKRNFMESTPEPRPNEWEKRRITPLSLQTQGSLE 684
            :||||||||||||:|||.|::|||||||||||||.||||||||||||||||.|||:.:.:|||||
 Frog   619 ENIYVRHSNLMLEDLDKTQDEILKHQASISELKRTFMESTPEPRPNEWEKRCITPVPMPSQGSLE 683

Human   685 EEITSILFSEKGFSDSMKATFTSATTWTAEGAV----VSANAPSEKLSSSPFSHLLETRAPESEG 745
            |||||||||::.|: .|..|...:|...|||:.    |:|:..|...|:.|     |...|.:.|
 Frog   684 EEITSILFSKESFT-CMNFTCAPSTQRPAEGSFMKDRVTADTFSNTHSAQP-----ENFIPRARG 742

Human   746 PCTGARDAVKSSHETLNIVEEKKRAEVGKDERVITEE----MNGKEISPGSGPGEIRKVEPVTQK 806
            ..||..||.::|.|   :|||.|:::....|..|.|:    :||:..|......:..:||.:.:|
 Frog   743 MRTGLSDAHENSDE---MVEETKQSDSDTSEPSIAEDIKVGVNGEADSFNDAVEQSTEVEDIEKK 804

Human   807 DSTSLSSESSSSSSESEEEDVGEYRPHHRVTEGTIREEQEYEEEVEEEPRPAAKVVEREEAVPEA 871
            |..||||...:|.||:||   .||:...|.:|..::||.:...||         ||:.|    |.
 Frog   805 DKESLSSSDGNSDSENEE---AEYQTESRCSEDVLKEEPQETPEV---------VVQTE----ED 853

Human   872 SPVTQAGASVITVE--TVIQENVGA-------QKIPGEKSVHEGALKQDMGEEAEEEPQKVNGEV 927
            :.||:|..|.:||.  .||.:||..       :......:|:|        |..::|..|:||:|
 Frog   854 NQVTKADGSSVTVAHLEVITDNVTKEVTITTFESCENNITVNE--------EVPQDEQPKINGDV 910

Human   928 SHVDIDVLPQIICCSEPPVVKTEMVTISDASQRTEISTKEVPIVQTETKTITYESPQIDGGAGGD 992
            ||:|:|...:||||||||||||||||||||:||||||||||||||||||||||||.|:|.....:
 Frog   911 SHIDVDTSSEIICCSEPPVVKTEMVTISDATQRTEISTKEVPIVQTETKTITYESAQLDDSGDLE 975

Human   993 SGTLLTAQTITSESVSTTTTTHITKTVKGGISETRIEKRIVITGDGDIDHDQALAQAIREAREQH 1057
            .|.||:||||||:||.||||||||||.|||||||||||||||:||.|||||:||||||:||:|||
 Frog   976 PGVLLSAQTITSDSVLTTTTTHITKTGKGGISETRIEKRIVISGDSDIDHDEALAQAIKEAKEQH 1040

Human  1058 PDMSVTRVVVHKETELAEEGED 1079
            ||||:|||||||||||.||.|:
 Frog  1041 PDMSITRVVVHKETELMEEEEE 1062

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EPB41L2	XP_024302117.1	Neuromodulin_N	<9..222	CDD:331332	76/227 (33%)
		B41	220..409	CDD:214604	142/188 (76%)
		FERM_C_4_1_family	404..497	CDD:270005	85/92 (92%)
		FA	507..549	CDD:312314	37/41 (90%)
		SAB	630..673	CDD:309500	36/42 (86%)
		4_1_CTD	967..1072	CDD:310467	84/104 (81%)
epb41l2	XP_031758369.1	B41	206..396	CDD:214604	142/189 (75%)
		FERM_C_4_1_family	391..484	CDD:270005	85/92 (92%)
		FA	494..537	CDD:400882	38/42 (90%)
		SAB	629..669	CDD:398195	34/39 (87%)
		PTZ00341	<749..905	CDD:173534	53/182 (29%)
		4_1_CTD	950..1052	CDD:399118	81/101 (80%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	183	1.000	Domainoid score	I17071
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H37478
Inparanoid	1	1.050	997	1.000	Inparanoid score	I3126
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D104938at7742
OrthoFinder	1	1.000	-	-		FOG0001068
OrthoInspector	1	1.000	-	-		oto152984
Panther	1	1.100	-	-	LDO	PTHR23280
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1151
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	10.160