DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema6c and Sema1b

DIOPT Version :9

Sequence 1:	NP_001258953.1	Gene:	Sema6c / 20360	MGIID:	1338032	Length:	963	Species:	Mus musculus
Sequence 2:	NP_001163178.1	Gene:	Sema1b / 37007	FlyBaseID:	FBgn0016059	Length:	770	Species:	Drosophila melanogaster

Alignment Length:	732	Identity:	236/732 - (32%)
Similarity:	340/732 - (46%)	Gaps:	137/732 - (18%)

- Green bases have known domain annotations that are detailed below.

Mouse    11 LLLLLLLSSLPQAQAAFPQDPTPLLTSDLQGASPSSWFRGLEDDAVAAELG--LDFQRFLTLN-R 72
            ::||:.||.|.......| |..|    |||..         :|..:|..:|  .|:.:.|..| .
  Fly    19 MILLITLSGLTIVAGWMP-DVKP----DLQTK---------QDKVLAHFIGNSTDYFKILDHNDE 69

Mouse    73 TLLVAARDHVFSFDLQAQEEGEGLVPNKFLTWRS--QDMENCAVRGKLTDECYNYIRV--LVPWN 133
            .:||.|:|.:::..|      .||.....|.|.|  .|.|.||::||...:|:||:||  |.| |
  Fly    70 FVLVGAKDVIYNVSL------NGLKEIARLEWHSTDADRELCALKGKHEWDCHNYLRVYALRP-N 127

Mouse   134 SQTLLACGTNSFSPMCRSYGITSLQQEGEE-----------------LSGQARCPFDATQSTVAI 181
            .:.|| |||||:.|.||.|  |.::...||                 :..|..||:....::...
  Fly   128 GEVLL-CGTNSYKPRCRHY--TPVEVSSEEAGSAGHAHAMRYEVSRDVEAQGLCPYSPAHNSTYA 189

Mouse   182 FAEGSLYSATAADFQASDAVVYRSLGPQPPLRSAKYDSKWLREPHFVYALEHGEHVYFFFREVSV 246
            ||:|.|||||.|||...|.::||.     .||:.:||.|.|.:|.||.|:|...:|.|||||:|:
  Fly   190 FADGHLYSATVADFSGGDPLIYRE-----NLRTEQYDLKQLNQPDFVGAIERNGYVLFFFRELSM 249

Mouse   247 EDARLGRVQFSRVARVCKRDMGGSPRALDRHWTSFLKLRLNCSVPGDSTFYFDVLQSLTGPVNLH 311
            |....|:..:||||||||.|.|| |.:..:.||||||.||||||||:..||||.:|:::..|...
  Fly   250 EVMNFGKAVYSRVARVCKNDRGG-PYSHGKSWTSFLKARLNCSVPGEFPFYFDEIQAISPIVESG 313

Mouse   312 GRSALFGVFTTQTNSIPGSAVCAFYLDDIERGFEGKFKEQRSLDGAWTPVSEDKVPSPRPGSCAG 376
            .:|.::.||||..|:|||||||||.:|||...|:|:||.|:.....|.||..::||.||||.|.
  Fly   314 SKSLIYAVFTTSVNAIPGSAVCAFNVDDILAAFDGEFKSQKDSQSHWLPVEREQVPKPRPGQCV- 377

Mouse   377 VGAAASFSSSQDLPDDVLLFIKAHPLLDPAVPPATHQPLLT-------LTSRALLTQVAVDGMAG 434
                   ..|:.|....:.|||.|||::.|||....:||||       ||:.|:..|  |..::|
  Fly   378 -------EDSRTLTSIAVNFIKNHPLMEEAVPAVHGRPLLTKVNLHHRLTAIAVHPQ--VKSLSG 433

Mouse   435 PHRNTTVLFLGSNDGTVLKVLPPGGQSLGSEP---------IVLEEIDAYSHARCSGKRSPRAAR 490
            .:.:  |::.|::||.|.|.:    ..|.:.|         :|:.|:....           ...
  Fly   434 AYYD--VIYSGTDDGKVTKFI----NILSTHPNSTVDRLKTVVISEMQVLP-----------LGT 481

Mouse   491 RIIGLELDTEGHRLFVAFPGCIVYLSLSRCARHGACQRSCLASLDPYCGW----HRSRGCMSIRG 551
            .|..|.:.|..:.|.|...|.:|.:.|..|:....| ..||:..||.|.|    |..:...:.:.
  Fly   482 PIRELVISTSKNSLVVVSDGSLVSVPLHHCSHIVDC-LGCLSLQDPICAWDLQTHECKNLATSQH 545

Mouse   552 PGGTDVDLTGNQESTEHGDCQDGATGSQSGPGDS--AYVLLGPGPSPETPSSPSD--AQQGPQSS 612
            ..||...|. :..||:...........:..||..  ::|.:.|.|:.|.....|:  :.||.|.|
  Fly   546 KFGTKTYLQ-SLNSTKKAAALLCPHIPRDAPGAETVSFVTMAPPPTEEQKLLYSNVGSSQGNQPS 609

Mouse   613 ----TLGAHTQGVRR---------DLSP-------ASAS------RSIPIPLLLACVAAAFALGA 651
                ..|....|:.:         |:.|       ::||      .|.|..:||..:.....|..
  Fly   610 LEQQPTGGDDFGLNKITLTSMDPDDIMPNLNDPQKSTASVDEIKYASTPSFMLLTTIVFFTFLVG 674

Mouse   652 SVSGLLVSCACRRANRR 668
            .::|:    .|.:|..|
  Fly   675 GIAGI----CCVKAKSR 687

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema6c	NP_001258953.1	Sema	54..518	CDD:387663	183/503 (36%)
		PSI	519..>540	CDD:214655	7/20 (35%)
		PHA03247	<714..956	CDD:223021
Sema1b	NP_001163178.1	Sema_1A	55..511	CDD:200498	183/498 (37%)
Sema1b	NP_001163178.1	PSI	510..>537	CDD:214655	9/27 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	317	1.000	Domainoid score	I1262
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	370	1.000	Inparanoid score	I2107
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8703
orthoMCL	1	0.900	-	-		OOG6_101616
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X415
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.860