DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment EPB41L1 and HPF1

DIOPT Version :9

Sequence 1:	XP_011526969.1	Gene:	EPB41L1 / 2036	HGNCID:	3378	Length:	1585	Species:	Homo sapiens
Sequence 2:	NP_014487.1	Gene:	HPF1 / 854010	SGDID:	S000005515	Length:	967	Species:	Saccharomyces cerevisiae

Alignment Length:	869	Identity:	168/869 - (19%)
Similarity:	261/869 - (30%)	Gaps:	251/869 - (28%)

- Green bases have known domain annotations that are detailed below.

Human   713 SPGGAALASGRTLAEKLLEGSELRADTREATIRNRCMSDGQPEGQTELRKGLEEPHTCGRPTAPG 777
            |....|::|..:.:..:....||.:.|.:.:           ...|||.....|   .....||.
Yeast    34 SNSSTAVSSTSSGSVSISSSIELTSSTSDVS-----------SSLTELTSSSTE---VSSSIAPS 84

Human   778 TRPAEV--DVLSPASDKGGLQSFLLDPAHAEARAELSNETDTSFAERSFYLNYEEKDSEDQVLPP 840
            |..:||  .:.|..|...| .|.:.....:.:.:..:.|:.:|.:..|     ...:|...|...
Yeast    85 TSSSEVSSSITSSGSSVSG-SSSITSSGSSVSSSSSATESGSSASGSS-----SATESGSSVSGS 143

Human   841 PLEERKGRLDAPPGGEPRPTLNSLDLRVSAAASSRSKDEAHMTSPKEGAGTPKNHGGPGDLKGSP 905
            ......|...|...|             |:.:.|.|..|:..::....:.|.......|....:.
Yeast   144 STSITSGSSSATESG-------------SSVSGSTSATESGSSASGSSSATESGSSASGSSSATE 195

Human   906 AGQTFAEGWEDAQWGVEGEFPHLTASAAREEGTPVSGDLLGKAEESPTE--ELKKHPPHRGQGVH 968
            :|.:           |.|      :|:|.|.|:.|||      ..|.||  .....|...|....
Yeast   196 SGSS-----------VSG------SSSATESGSSVSG------SSSATESGSASSVPSSSGSVTE 237

Human   969 PDPQACALPRAIPLNVRKPVKPDRGNFPPKERGVVPTQKGGAELKDREASAFLHMEVIIPLPASP 1033
            ....:.|...:|..:     ....|:......|.| ||.|.:......:||             |
Yeast   238 SGSSSSASESSITQS-----GTASGSSASSTSGSV-TQSGSSVSGSSASSA-------------P 283

Human  1034 GHSEDLAALEEASPSPTSHG---SGEPSELREPFLRHVHLSKASPEPKDQVGFVVSPATGGERRP 1095
            |.|..:.  :..|.:.|:.|   ||..|.:..........:..|....|...::.|....|:
Yeast   284 GISSSIP--QSTSSASTASGSITSGTLSSITSSASSATATASNSLSSSDGTIYLPSTTISGD--- 343

Human  1096 PPITSRKPRVVPEEAE----GRIPLGFG-----------------------FPSGKRREMTSFQA 1133
              ||.....:..|..|    |::.|..|                       :|.      |.|
Yeast   344 --ITLTGSVIATEAVEVAAGGKLTLLDGDKYVFSADFIIHGGVFVEKSKPTYPG------TEF-- 398

Human  1134 GDQEGSLEDISKTSVANKIRIFETHGAETRRMSEGEARSL-PN--DVSSEAPVGQAEQQRSTLSD 1195
             |..|...|:|           .|..||....|...|.|. |.  |.|.:..:..:|   ||..:
Yeast   399 -DISGENFDVS-----------GTFNAEEPAASSASAYSFTPGSFDNSGDISLSLSE---STKGE 448

Human  1196 LGFAQLQPPGDFASPKA--THSTVIPLATRHFREDTSASYQEAHTE-------LEPVSPNSGCET 1251
            :.|:.....|.|:...|  ...:|..|..|  .|..|.:..|.:.|       :||||
Yeast   449 VTFSPYSNSGAFSFSNAILNGGSVSGLQRR--AESGSVNNGEINLENGSTYVVVEPVS------- 504

Human  1252 TLAEATGTGRAGLREGSEEKVKPPRPRAPESDTGDEDQDQERDTVFLKDNHLAIERKCSSITVSS 1316
                  |:|...:..|:...      ..|::.||       :..||..:..||::...::.|...
Yeast   505 ------GSGTINIISGNLYL------HYPDTFTG-------QTVVFKGEGVLAVDPTETNTTPIP 550

Human  1317 TSSLEAEVDFTVIGDYHGSAFEDFSRSLPELDRDKSDS-------DTEGLLFSRDLNKGAPSQDD 1374
            ......|....:..|....:::..:..|.....:...|       .:.|...|.....||.:...
Yeast   551 VVGYTGENQIAITADVTALSYDSATGVLTATQGNSQFSFSIGTGFSSSGFNVSEGTFAGAYAYYL 615

Human  1375 ESGGIEDSPDRGACSTPDMPQFEPVKTETMTVSSLAIRKKIEPEAVLQTRVSAMDNTQQVDGSAS 1439
            ..||:..|     .:||         :.|.|.|..                     |....||.|
Yeast   616 NYGGVVAS-----SATP---------SSTSTTSGA---------------------TNSTSGSTS 645

Human  1440 VGREFIATTPSITTETISTTMENSLKSGKGAAAMIPGPQTVATEIRSLSPIIGKDVLTSTYGATA 1504
            .|       .|:|..|.||:...|: :|..|:.:|.|..:|.|             .|.||..|.
Yeast   646 FG-------ASVTGSTASTSFGASV-TGSTASTLISGSPSVYT-------------TTLTYATTT 689

Human  1505 ET--LSTSTTTH-------VTKTV 1519
            .|  :|.|.||.       :|.||
Yeast   690 STVVVSCSETTDSNGNVYTITTTV 713

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EPB41L1	XP_011526969.1	B41	124..313	CDD:214604
		FERM_N	126..189	CDD:286467
		FERM_M	208..313	CDD:278785
		FERM_C_4_1_family	308..401	CDD:270005
		FA	410..450	CDD:285894
		SAB	518..>549	CDD:282265
		4_1_CTD	<1495..1572	CDD:283537	12/34 (35%)
HPF1	NP_014487.1	Hyphal_reg_CWP	337..617	CDD:403079	62/335 (19%)
HPF1	NP_014487.1	Herpes_BLLF1	<643..937	CDD:282904	27/92 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23280
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100