DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment EPB41L1 and si:dkey-178k16.1

DIOPT Version :9

Sequence 1:	XP_011526969.1	Gene:	EPB41L1 / 2036	HGNCID:	3378	Length:	1585	Species:	Homo sapiens
Sequence 2:	XP_009294955.1	Gene:	si:dkey-178k16.1 / 569390	ZFINID:	ZDB-GENE-090312-61	Length:	1273	Species:	Danio rerio

Alignment Length:	1634	Identity:	602/1634 - (36%)
Similarity:	755/1634 - (46%)	Gaps:	510/1634 - (31%)

- Green bases have known domain annotations that are detailed below.

Human    79 TERSVKSLDMEEKDYSEADGLSERTTPSKAQKSPQKIAKKYKSAICRVTLLDASEYECEVEKHGR 143
            |:...|..|    ::.:.|..||: |||:..:|||| :|:.|:...:|.|||.|.||..|||..:
Zfish    17 TDHDSKMSD----EHRDTDDSSEK-TPSRMSRSPQK-SKRPKTVPVKVLLLDGSAYESGVEKLCK 75

Human   144 GQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKEIKKQIRSSPWNFAFTVKFYPPDPAQL 208
            ||||.|:|||||||||||||||:|.|.:.||||||||||||||||..||:|:|.||||||||:||
Zfish    76 GQVLLDMVCEHLNLLEKDYFGLSFSDTECQKNWLDPSKEIKKQIRVGPWHFSFAVKFYPPDPSQL 140

Human   209 TEDITRYYLCLQLRADIITGRLPCSFVTHALLGSYAVQAELGDYDAEEHVGNYVSELRFAPNQTR 273
            .|||||||||||||.||::|||||||||||||||||:||||||||.|||..:|::|.||||||||
Zfish   141 IEDITRYYLCLQLREDILSGRLPCSFVTHALLGSYAIQAELGDYDPEEHGPDYINEFRFAPNQTR 205

Human   274 ELEERIMELHKTYRGMTPGEAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDR 338
            |||||:||||:|||||:|.||||:||||||||||||||||||||||||||||||||:||||||||
Zfish   206 ELEERVMELHRTYRGMSPAEAEINFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCASGLLIYRDR 270

Human   339 LRINRFAWPKILKISYKRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVS 403
            |||||||||||||||||||||||||||||||||||||||||||||::||||||||||||||||||
Zfish   271 LRINRFAWPKILKISYKRSNFYIKIRPGEYEQFESTIGFKLPNHRASKRLWKVCIEHHTFFRLVS 335

Human   404 PEPPPKGFLVMGSKFRYSGRTQAQTRQASALIDRPAPFFERSSSKRYTMSRSLDGAE-------- 460
            ||||||||||:|||||||||||||:||||||||||||.||||.|:||.:|||:||..
Zfish   336 PEPPPKGFLVIGSKFRYSGRTQAQSRQASALIDRPAPQFERSISRRYLLSRSIDGESALGDTMDR 400

Human   461 -----FSRPA-------------SVSENHDAGPDGDKRDEDGESGGQRSEAEEGEVRTPTKIKEL 507
                 .|.|.             ..|.:.|...|.::.:|      ||.|::.    ||:|..||
Zfish   401 LSQHTSSEPVPSLPRDELDQDYLEPSLDQDLDQDHEQEEE------QRLESDS----TPSKTVEL 455

Human   508 KPE-------------QETTPRHKQE-FLDKPEDVLLKHQASINELKRTLKEPNSKLIHRDRDWE 558
            |.|             |:.|||.||| |||||||||.|||||||||||.|:||||||:|
Zfish   456 KREEAGSPVDSKTELDQDLTPRPKQEQFLDKPEDVLQKHQASINELKRALREPNSKLVH------ 514

Human   559 RERRLPSSPASPSPKGTPEKANESQRT-----QDISQRDLVPEPGAAAGLEVFTQKSLAASPEGS 618
            ||:||    :..|...||||.:.|:.:     ||..|||
Zfish   515 REKRL----SGASSGSTPEKKSASEESLLIEKQDGCQRD-------------------------- 549

Human   619 EHWVFIEREYTRPEELGLLKVTTMQQEERQAGLAGILANGRLSKVDVLVDKFKVEVATEEMVGNR 683
                              |.::...::.|...:|. ||.|                      .||
Zfish   550 ------------------LPLSKKDEKSRSPRVAS-LATG----------------------FNR 573

Human   684 RANTQQQGKMIASPEDFESVGEEGPWIRESPGGAALASGRTLAEKLLEGSELRADTREATIRNRC 748
            ..:.:.:.|.|.|                       .:.||..|.:|        :.|..:|||.
Zfish   574 ETDDRVREKNIIS-----------------------VAKRTSTENIL--------SPEKPLRNRA 607

Human   749 MSD----GQPEGQTEL-RKGLEEPHTCGRPTAPGTRPAEVDVLSPASDKGGLQSFLLDPAH---A 805
            .|.    ...:|...| .|..:..|:..||.      :|..:.:...|....:....|..:   .
Zfish   608 KSPALRYNHFQGINSLDEKAYDNGHSHDRPL------SENVIHTNGCDTYATERLWGDKKYMGVT 666

Human   806 EARAELSNETDTSFAERSFYLNYEEKDSEDQVLPPPLEERKGRLDAPPGGEPRPTLNSLDLRVSA 870
            ....|.:|:....:.||||                              ||..|...........
Zfish   667 NIEHETTNQDLARYVERSF------------------------------GEASPNAAMDKYMRDR 701

Human   871 AASSRSKDEAHMTSPKEGAGTPKNHGGPGDLKGSPAGQTFAEGWEDAQWGVEGEFPHLTASAARE 935
            ...||.:.:::...|:....|........|.||.  |.|.                      .|.
Zfish   702 YNESRCERQSYEKEPENTRATLLKQTSKADPKGK--GSTI----------------------QRH 742

Human   936 EGTPVSGDLLGKAEESPTEELKKHPPHRGQGVHPDPQACALPRAIPLNVRKPVKPDRGNFPPKER 1000
            :.|         |.::...|||                    |.:||      ||:|..
Zfish   743 DST---------ASDTSQSELK--------------------RIVPL------KPERSK------ 766

Human  1001 GVVPTQKGGAELKDREASAFLHMEVIIPLPASPGHSEDLAALEEASPSPTSHGSGEPSELREPFL 1065
                      :||||:.:..                                 .|:|||
Zfish   767 ----------KLKDRKGAKL---------------------------------QGQPSE------ 782

Human  1066 RHVHLSKASPEPKDQVGFVVSPATGGERRPPPITSRKPRVVPEEAEGRIPLGFGFPSGKRREMTS 1130
            |.:                    :|.......|.|::.:||.|.|                 :.:
Zfish   783 RSI--------------------SGSFDESEGINSKEDQVVFENA-----------------LDT 810

Human  1131 FQAGDQEGSLEDISKTSVANKIRIFETHGAETRR------MSEGEARSLPNDVSSEAPVGQAEQQ 1189
            ........:||.|.  :.|.:......|..|||.      ....:.|.|.|::.....:   ||.
Zfish   811 LSQSKNSATLESIG--TFAKQDWASNYHNWETREYIRQSVQDRPQLRDLKNNIDHRLSI---EQD 870

Human  1190 RSTLSDLGFAQLQPPGDFASPKATHST----------VIPLATRHFREDTSASYQEAHTELEPVS 1244
            :....|       |...|..|  |:||          ..|:.::..||          |..:|::
Zfish   871 QFLFDD-------PLFMFDFP--TNSTFPAFDQIAPLYPPVKSQRARE----------TRTKPIT 916

Human  1245 PNSGCETTLAEATGTGRAGLREGSEEK-VKPPRPRAPESDTGDEDQDQERDTVFLKDNHLAIERK 1308
            .:.       ......::...|.|:.| |:.|..|...|.:.|   |.:.||::||:.||.||||
Zfish   917 KSD-------SGNSLHKSSAMESSKRKSVREPWERRLGSVSED---DPDPDTLYLKETHLGIERK 971

Human  1309 CSSITVSSTSSLEAEVDFTVIGDYHGSAFEDFSRSLPELDRDKSDSDTEGLLFSRDLNKGAPSQD 1373
            ||||||||||||||||||||:.|:. :..|:|||.:.||
Zfish   972 CSSITVSSTSSLEAEVDFTVLMDFQ-TGMEEFSRGMTEL-------------------------- 1009

Human  1374 DESGGIEDSPDRGACSTPDMPQF----------------------------EPVKTETMTVSSLA 1410
               |..:.|||.|....|..|.|                            ||...|........
Zfish  1010 ---GEKDYSPDFGLSDRPTHPAFILGADPIYLPEERHVEVQRPVEKPKPVVEPKPPEERKPEPFV 1071

Human  1411 IRKKIEPEAVLQTRVSAMDNTQQVDGSASVGREFIATTP--SITTETISTTMENSLKSGKGAAAM 1473
            .:|  .|.:|...:....|:|:|.: :.|:.||...:.|  .::.|:.......:|:..:.....
Zfish  1072 PKK--APRSVKAAQALRKDSTEQAN-AQSMRRESSESPPIHPLSRESSEIIASQALRKTEVKIET 1133

Human  1474 IPGPQTVATEIRSL---------------------SPI--------IGKDVLTSTYGATAETLST 1509
            .|....|.|.|..:                     ||:        :|......:.....|.:::
Zfish  1134 QPNGSEVTTTIMEIADPDHGISGMREAAYSMTERVSPVCQSFHRVNLGSLARDGSPLMVTENVTS 1198

Human  1510 STTTHVTKTVKGGFSETRIEKRIIITGDEDVDQDQALALAIKEAKLQHPDMLVTKAVVYRETDPS 1574
            :||||||||||||:||||||||||||||:|||||||||:||||||.||||||||||||.|||:.|
Zfish  1199 ATTTHVTKTVKGGYSETRIEKRIIITGDDDVDQDQALAMAIKEAKQQHPDMLVTKAVVVRETESS 1263

Human  1575 ---PEERDK 1580
               |.|..|
Zfish  1264 TQDPHEESK 1272

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EPB41L1	XP_011526969.1	B41	124..313	CDD:214604	148/188 (79%)
		FERM_N	126..189	CDD:286467	47/62 (76%)
		FERM_M	208..313	CDD:278785	87/104 (84%)
		FERM_C_4_1_family	308..401	CDD:270005	89/92 (97%)
		FA	410..450	CDD:285894	34/39 (87%)
		SAB	518..>549	CDD:282265	27/31 (87%)
		4_1_CTD	<1495..1572	CDD:283537	56/76 (74%)
si:dkey-178k16.1	XP_009294955.1	B41	56..245	CDD:214604	148/188 (79%)
		FERM_N	58..120	CDD:286467	46/61 (75%)
		FERM_M	138..245	CDD:278785	88/106 (83%)
		FERM_C_4_1_family	240..333	CDD:270005	89/92 (97%)
		FA	342..383	CDD:285894	35/40 (88%)
		SAB	482..522	CDD:282265	32/49 (65%)
		4_1_CTD	<1210..1261	CDD:283537	45/50 (90%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	196	1.000	Domainoid score	I13186
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	845	1.000	Inparanoid score	I3165
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG41985
OrthoDB	1	1.010	-	-		D104938at7742
OrthoFinder	1	1.000	-	-		FOG0001068
OrthoInspector	1	1.000	-	-		oto47848
orthoMCL	1	0.900	-	-		OOG6_101605
Panther	1	1.100	-	-	LDO	PTHR23280
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1151
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.980