DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment EPB41L1 and cora

DIOPT Version :9

Sequence 1:	XP_011526969.1	Gene:	EPB41L1 / 2036	HGNCID:	3378	Length:	1585	Species:	Homo sapiens
Sequence 2:	NP_523791.2	Gene:	cora / 37205	FlyBaseID:	FBgn0010434	Length:	1698	Species:	Drosophila melanogaster

Alignment Length:	1844	Identity:	496/1844 - (26%)
Similarity:	758/1844 - (41%)	Gaps:	529/1844 - (28%)

- Green bases have known domain annotations that are detailed below.

Human   100 SERTTPSKAQKSPQKIAKKY-KSAICRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYF 163
            :|..||:|::  |:..:..: |.|:.||||||.|..:..:::...|:.:.:.:|..|||:|||||
  Fly    11 AEPETPTKSK--PKSSSSSHGKPALARVTLLDGSLLDVSIDRKAIGRDVINSICAGLNLIEKDYF 73

Human   164 GLTFCDADSQKNWLDPSKEIKKQIRSSPWNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITG 228
            |||:......:.|||..|.:.|..|:..|...|.||||||:|:||.||||||:||||:|.||:.|
  Fly    74 GLTYETPTDPRTWLDLEKPVSKFFRTDTWPLTFAVKFYPPEPSQLKEDITRYHLCLQVRNDILEG 138

Human   229 RLPCSFVTHALLGSYAVQAELGDYDAEE-HVGNYVSELRFAPNQTRELEERIMELHKTYRGMTPG 292
            ||||:||||||||||.||:|:||||||| ....|:.:.:.|||||.|||:::|:||||::|.:|.
  Fly   139 RLPCTFVTHALLGSYLVQSEMGDYDAEEMPTRAYLKDFKIAPNQTAELEDKVMDLHKTHKGQSPA 203

Human   293 EAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKISYKRS 357
            |||:|:|||||||:|||||||.||||||:||||||||:|||:|||:||||||||||||||||||.
  Fly   204 EAELHYLENAKKLAMYGVDLHPAKDSEGVDIMLGVCASGLLVYRDKLRINRFAWPKILKISYKRH 268

Human   358 NFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEPPPKG--FLVMGSKFRY 420
            :|||||||||:||:||||||||.|||:||:|||.|:||||||||::|||..|.  |.|.||.:||
  Fly   269 HFYIKIRPGEFEQYESTIGFKLANHRAAKKLWKSCVEHHTFFRLMTPEPVSKSKMFPVFGSTYRY 333

Human   421 SGRTQAQTRQASALIDRPAPFFERSSSKRYTMSRSLDG---AEFSRPASVSENHDAGPDGDKRDE 482
            .|||||::  .:..:||..|.|.|:.|.....|||:|.   ||..:.|..|...|...|   |:.
  Fly   334 KGRTQAES--TNTPVDRTPPKFNRTLSGARLTSRSMDALALAEKEKVARKSSTLDHRGD---RNA 393

Human   483 DGESGGQRSEAEEGEVRTPTKIKELKPEQETTPRHKQEFLDKPEDVLLKHQASINELKRTLKEPN 547
            ||::          ..|:|.|.|            |::..||        :|.:.|.|:..||..
  Fly   394 DGDA----------HSRSPIKNK------------KEKDADK--------EAKLREKKQKEKEEK 428

Human   548 SKLIHRDRDWERERR--------LPSSPASPSPKGTPEKANESQRTQDISQRDLVPEPGAAAGLE 604
            .:.....|:.|.:::        |.:..|:.:.....::.|:|.::...|.|         .|:.
  Fly   429 ERKEREKRELEEKKKAEKAAKAALAAGAAAGAAVNGNDELNDSNKSDKSSGR---------RGVG 484

Human   605 VFT--QKSLAASP-------EGSEHWVFIEREYTRPEELGLLKVTTM---QQEERQAGLAGILAN 657
            :|:  :||.:.||       .|.:.    ::|..|   |||:..:.:   ||::.....|...|.
  Fly   485 IFSSGRKSKSGSPSKDGKDKSGKDK----DKEVGR---LGLVVTSGLGDNQQDQNLDEAARNAAK 542

Human   658 GRLSKVDVLVDKFKVEVATEEMVGN----RRANTQQQGKMIASPEDFESVGEEG-----PWIRES 713
            .|.|....:..:::..|..:   ||    |::.|....:....|...:| |.:|     |..::.
  Fly   543 NRGSTTPGVTRQYEYAVDND---GNTSPTRKSYTPGGFRYDQDPNSRKS-GADGQEQLSPTSQQK 603

Human   714 PGGAAL--ASG-----RTLAEKLLEGSELRADTREATIRNRCMSDGQPEGQTELRKGLEEPHTCG 771
            ..|.|.  |.|     :..||||..| :|...|::...|.:.    .|:.:.:|   |::|
  Fly   604 KIGLAFNYAPGNENALKETAEKLKAG-QLSPRTQDKLNRGQL----SPKSRAKL---LQDP---- 656

Human   772 RPTAPGTRPAEVDVLSPASDKGGLQSFLLDPAHAEARAELSNETDTSF------------AERSF 824
                         :|||.: :..||...:|    .|...||:....|:            |..|:
  Fly   657 -------------LLSPTT-RAKLQGSAVD----AAAVPLSDSQKRSYSPTKGPQGYSSGAPGSY 703

Human   825 ---------YLNYEEKDSEDQVLPPPLEERKGRLDAPPG----GEPRPTLNSLDLRVSAAASSRS 876
                     :|..:..:.|...:.|...:....|....|    |.|..|........:|||:..:
  Fly   704 KPISDPTADFLESQRYNKEPGYVGPSKADVAAGLAGAAGSKKPGSPTKTGKGAPGAAAAAAAGAA 768

Human   877 KDEAHMTSPKE------------GAGTPKNHGGPGDLKGSPAGQTFAEGWEDAQWGV----EGEF 925
            ...|....||:            ...|.:.....|.::.|......|.|..|.::||    :|..
  Fly   769 GAAAAAAKPKKRRVKIMVITSKFDPSTKRIDAENGSIEHSTGILDPATGLIDTKYGVIDPKKGTL 833

Human   926 PHLTASAAREEGTPVSGDLLGKAEESPTEELKKHPPHRGQGVHPDPQ-----------ACALPRA 979
            ..|.....::|  ...||:.||     |..|     |...|| .||:           .|..|:.
  Fly   834 EALNTKTGKKE--VFQGDVDGK-----TGNL-----HLVSGV-ADPKTGRLDDTLGQIVCITPQD 885

Human   980 IPL----NVRKPVKPDRGNFPP-------------KERGVVPTQKGGAELKDREASAFLHMEVII 1027
            .|:    .:...:.|..|....             .:.|::.|:.|  |:..|...
  Fly   886 NPVVELTVITSRIDPATGKIDTVNGDVERSLGVLNLDTGLLDTKYG--EINTRTGE--------- 939

Human  1028 PLPASPGHSEDLAALEEASPSPTSHGSGEPSELR--EPFLRHVHLSKASPEPKD--QVGFVVSPA 1088
             |.|....|..:...:.....|   |:|:.:.|.  :|     ..:|..|....  :||..:.|.
  Fly   940 -LKAIDPKSGKIVVSKNVKVDP---GTGQITILGIVDP-----KTNKIDPNQGRLIEVGQQIDPI 995

Human  1089 TGGERRPPPITSRKPRVVPEEAEGRIPLGFGFPSGKRREMTSFQAGDQEGSLEDISKT------- 1146
            ...........|::..:.|:.|:..       .||.:.:..:.:...:.|.::.:..|
  Fly   996 VEVTSLAGKFDSKRNIIDPKTAQVE-------TSGGQFDPKAGKIDTKYGQIDLVKHTITFNDPK 1053

Human  1147 ---SVANKIRIFETHGAETRRMSEGEARSLPN----------------DVSSEAPVGQ--AEQQR 1190
               :|...|:|..|.|....:.......:.|:                |.:::||:.:  |.:.:
  Fly  1054 SGKTVTRDIKIEPTTGQIVLKNQVNPKNNKPDKDYARIISLRIVQQRVDPATKAPITEVSASKDK 1118

Human  1191 STLSDLGFAQLQPPGDFASPKATH-----STVIP----LATRHFREDTSASYQEAHTELEP---- 1242
            ..:.|....|:..|.....|....     |:|.|    :.|.:...|...:..:..|:|:|
  Fly  1119 DIVVDPKSNQIWVPTGATDPATKEQQYISSSVDPKTGYVITIYGYLDPKTNEIKKQTKLDPNTIK 1183

Human  1243 VSPNSGCETT----LAEATG--------------------------TG-----RAGLREGSEEKV 1272
            :.|.||...|    :.:|||                          ||     |..|...::|:.
  Fly  1184 IEPTSGKIYTATGEVDQATGEPLYAATQVDPESGEVYTKLARVDPKTGKIVIVRILLISKTDERG 1248

Human  1273 KPPR--PRAPESD-----------------------TGDEDQDQERDTVFLKDNHLAIERKCSSI 1312
            :|..  |...|.|                       ||:..|....|..|..          :..
  Fly  1249 RPEEIDPSTCEIDPVSGRVLKFFNKTVYVYNMIDPVTGEIVQVDPNDPRFAG----------ART 1303

Human  1313 TVSSTSSLEAEVDFTVIGDYHGSAFEDFSRSLPELDRDKSDSD---------------------- 1355
            ||:.|.:|..|:| .|.|... |.:.|...:..::|...:.:|
  Fly  1304 TVTHTMTLTGEID-PVTGRIK-SEYGDIDPNTGDIDPATAVTDPVTGKLILNYAQIDPSHFGKQA 1366

Human  1356 -----TEGLLFSRD--------LNKGAPSQDDESGGIED----------------SPDRGA---- 1387
                 ||.:..:|.        ::|||..:|.|....:|                ||...|
  Fly  1367 QVQTTTETVPITRQQFFDGVKHISKGALRRDSEGSSDDDMTAQYGADQVNEILIGSPAGQAGGKL 1431

Human  1388 ---CSTPDMPQFEPVKTET---------------------------------------------- 1403
               .|||.:     |||.|
  Fly  1432 GKPVSTPTV-----VKTTTKQVLTKNIDGVTHNVEEEVRNLGTGEVTYSTQEHKADATPTDLSGA 1491

Human  1404 -MTVSSLAIR--------------KKIEPEAVLQTRVSAMDNTQQVDGSASVGREFIATTPSITT 1453
             :|.:::..|              :::|.:.|..||....:..||     .|..:.:.||.::|:
  Fly  1492 YVTATAVTTRTATTHEDLGKNAKTEQLEEKTVATTRTHDPNKQQQ-----RVVTQEVKTTATVTS 1551

Human  1454 -------ETISTTMENSLKSGKGAAAMIPGPQTVATEIRS---LSP-----------------II 1491
                   :::|:|      |...:...|.||...|:.:|:   .||                 ::
  Fly  1552 GDQYQRRDSVSST------SSGDSGTPIDGPYDGASVVRTDNQKSPLFTTSATTGPHVESTRVVL 1610

Human  1492 GKDVLTSTYGATAETLSTSTTTHVTKTV--------KGGFSETRIEKRIIITGDED-VDQDQALA 1547
            |:|  |..:....|.:||.|.:..|:||        :.|..|||:|::|.|..|.| :|.|:|||
  Fly  1611 GED--TPGFSGHGEIISTQTVSSKTRTVETITYKTERDGIVETRVEQKITIQSDGDPIDHDKALA 1673

Human  1548 LAIKEAKLQHPDMLVTKAVVYRET 1571
            .||:||...:|||.|.|..:.::|
  Fly  1674 EAIQEATAMNPDMTVEKIEIQQQT 1697

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EPB41L1	XP_011526969.1	B41	124..313	CDD:214604	107/189 (57%)
		FERM_N	126..189	CDD:286467	24/62 (39%)
		FERM_M	208..313	CDD:278785	71/105 (68%)
		FERM_C_4_1_family	308..401	CDD:270005	78/92 (85%)
		FA	410..450	CDD:285894	17/41 (41%)
		SAB	518..>549	CDD:282265	8/30 (27%)
		4_1_CTD	<1495..1572	CDD:283537	32/86 (37%)
cora	NP_523791.2	B41	34..224	CDD:214604	107/189 (57%)
		FERM_N	36..98	CDD:286467	24/61 (39%)
		FERM_M	116..224	CDD:278785	72/107 (67%)
		FERM_C_4_1_family	219..312	CDD:270005	78/92 (85%)
		FA	323..363	CDD:285894	17/41 (41%)
		PQQ_2	829..>972	CDD:290097	31/170 (18%)
		4_1_CTD	1612..1698	CDD:283537	33/88 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151661
Domainoid	1	1.000	168	1.000	Domainoid score	I3823
eggNOG	1	0.900	-	-		E1_KOG3530
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	519	1.000	Inparanoid score	I1279
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001068
OrthoInspector	1	1.000	-	-		otm41652
orthoMCL	1	0.900	-	-		OOG6_101605
Panther	1	1.100	-	-	LDO	PTHR23280
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4459
SonicParanoid	1	1.000	-	-		X1151
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.780