DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema6b and Sema1a

DIOPT Version :9

Sequence 1:	NP_001123928.1	Gene:	Sema6b / 20359	MGIID:	1202889	Length:	886	Species:	Mus musculus
Sequence 2:	NP_001260265.1	Gene:	Sema1a / 34192	FlyBaseID:	FBgn0011259	Length:	1131	Species:	Drosophila melanogaster

Alignment Length:	1065	Identity:	296/1065 - (27%)
Similarity:	445/1065 - (41%)	Gaps:	272/1065 - (25%)

- Green bases have known domain annotations that are detailed below.

Mouse    13 LSFFLLLLLGV--TYGLFPEEPPP---LSVAPRDYLSHYPVFVGSGPGRLTAAEGAEDLNIQRVL 72
            :..||||.:.|  ....:.|...|   :.:.|.|.|.    |||:        |...| :.:.|.
  Fly    50 MQVFLLLTVLVIGNQSAWQENIRPKLYVELGPEDVLK----FVGN--------ESVVD-HFKLVT 101

Mouse    73 RVNRTLFIGDRDNLYQVELEPSTSTELRYQRKLTWRSNPSDIDVCRMKGKQEGECRNFVKVLLLR 137
            :...:|.||.|:.::.:.:.     :|..|::|.|.|...|..:|.:|||.|..|:|:::::::.
  Fly   102 KDGNSLLIGARNTVFNLSIH-----DLVEQQRLVWTSPEDDTKMCLVKGKDEEACQNYIRIMVVP 161

Mouse   138 DESTLFVCGSNAFNPICANYSM-DTLQLLGDSISGMARCPYDPKHANVALFSDGMLFTATVTDFL 201
            ....|||||:|:|.|:|..|.: |:...|..:.:|.|.|||||:|.:.::.:|..|::.||.||.
  Fly   162 SPGRLFVCGTNSFRPMCNTYIISDSNYTLEATKNGQAVCPYDPRHNSTSVLADNELYSGTVADFS 226

Mouse   202 AIDAVIYRSLGDRPTLRTVKHDSKWFKEPYFVHAVEWGSHVYFFFREIAMEFNYLEKVVVSRVAR 266
            ..|.:|||.     .|:|.::||.....|.||.:...|..|||||||.|:||....|.:.|||||
  Fly   227 GSDPIIYRE-----PLQTEQYDSLSLNAPNFVSSFTQGDFVYFFFRETAVEFINCGKAIYSRVAR 286

Mouse   267 VCKNDVGGSPRVLEKQWTSFLKARLNCSVPGDSHFYFNVLQAVTGVV-----SLGGRPVILAVFS 326
            |||.|.|| |.....:||||||:|||||:|||..||||.:|:.:.:|     |:..: :|..||:
  Fly   287 VCKWDKGG-PHRFRNRWTSFLKSRLNCSIPGDYPFYFNEIQSASNLVEGQYGSMSSK-LIYGVFN 349

Mouse   327 TPSNSIPGSAVCAFDMNQVAAVFEGRFREQKSPESIWTPVPEDQVPRPRPGCCAAPGMQYNASSA 391
            ||||||||||||||.:..:|..|||:|:||....|.|.||...:||.||||.|      :|.|.|
  Fly   350 TPSNSIPGSAVCAFALQDIADTFEGQFKEQTGINSNWLPVNNAKVPDPRPGSC------HNDSRA 408

Mouse   392 LPDEILNFVKTHPLMDEAVPSLGHSPWIVRTLMRHQLTRVAVDVGAGPWGNQT--IVFLGSEAGT 454
            |||..|||:|||.||||.||:....|.:|||...::.|::|||......|.:|  ::|:|::.|.
  Fly   409 LPDPTLNFIKTHSLMDENVPAFFSQPILVRTSTIYRFTQIAVDAQIKTPGGKTYDVIFVGTDHGK 473

Mouse   455 VLKFLVKPNASVSGTTGPSIFLEEFETYRPDRCGRPSSAGEWGQRLLSLEL----------DAA- 508
            ::| .|...::.|.....|:.:||.:....            .:.:.:||:          |.:
  Fly   474 IIK-SVNAESADSADKVTSVVIEEIDVLTK------------SEPIRNLEIVRTMQYDQPKDGSY 525

Mouse   509 -SGGLLAAFPRCVVRVPVARC--QLYSGCMKNCIGSQDPYCGWAP-DGSCIFLRPGTSATFEQ-- 567
             .|.|:......||.:.:.||  ...:.| ..|:..|||||.|.. .|.|  ...|.....|:
  Fly   526 DDGKLIIVTDSQVVAIQLHRCHNDKITSC-SECVALQDPYCAWDKIAGKC--RSHGAPRWLEENY 587

Mouse   568 ---------------------DVSGASTSGLGDCTGLL--RASLSDDR---------------AG 594
                                 |.:.....|..:...||  |....|..               |.
  Fly   588 FYQNVATGQHAACPSGKINSKDANAGEQKGFRNDMDLLDSRRQSKDQEIIDNIDKNFEGPQISAD 652

Mouse   595 LVSVNLLVTSSVAAFVVGAVVS---GFSVGWFVGLRERRELARRKDKEAILAHGGSE-------- 648
            :::....|.:.|.|.:.|::.|   ||..|:|.|.|      ..||::..|.:..:|
  Fly   653 IINAQYTVETLVMAVLAGSIFSLLVGFFTGYFCGRR------CHKDEDDNLPYPDTEYEYFEQRQ 711

Mouse   649 ---AVLSVSRLGERRGTGPGGRGGAGGGP-----GGPPEALLAPLMQNGWTKAAL--LHGGPHDL 703
               :..|..|:.:.....|.........|     ..||..:.:|  :|...|..:  :|.||:.
  Fly   712 NVNSFPSSCRIQQEPKLLPQVEEVTYAEPVLLPQPPPPNKMHSP--KNTLRKPPMHQMHQGPNS- 773

Mouse   704 DT---------------------GLLPTPE-------------QTPLPQKRLPTPHPHAHALG-S 733
            :|                     |.|.:.:             .|...:|.:...:....:|| :
  Fly   774 ETLFQFQPDGYNTQQSYRGRDNFGTLRSHQVMGDNYRRGDGFSTTRSVKKAVNNTNTRNRSLGRA 838

Mouse   734 RAWDHSHALLSASASTSLLLLAPARASEQPQVP---------------------AEPGPESRLCA 777
            |.....|.:::...|.|     |.:..:|.|.|                     :.|.|:.   :
  Fly   839 RRQPPRHGIVTQHRSNS-----PQQQQQQSQQPHSSSGSSPVMSNSSSSPAPPSSSPSPQE---S 895

Mouse   778 PRSCR-------ASHPGDFPL----TPHASPDRRRVVSAPTGPLDPSVGDGLPGPWSPPATSSLR 831
            |::|.       ..:....||    :.||.|..:   |.| .||.|      |||.:|||....|
  Fly   896 PKNCSYIYRDXLICNTKSMPLIQAQSTHAQPHPQ---SHP-HPLPP------PGPTTPPAQPRAR 950

Mouse   832 RP---------------GPHGP----PTAALRRTH----TFNSGEARPGGHRPRRH--------- 864
            .|               .|..|    |:..|...|    ||:.|:..........|
  Fly   951 SPMIGRTYAKSMPVTPVQPQSPLAETPSYELYERHSDAATFHFGDEDDDDDDEHDHEDTSSLAMI 1015

Mouse   865 ---PPADSTHLLPCGTGERTAPPVP 886
               ||.|:.||:       .:||:|
  Fly  1016 TPPPPYDTPHLI-------ASPPLP 1033

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema6b	NP_001123928.1	Sema_6B	58..526	CDD:200528	181/487 (37%)
		PSI	527..573	CDD:214655	15/71 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	655..677		3/26 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	697..731		8/67 (12%)
		PHA03269	708..>875	CDD:165527	49/247 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	761..886		41/191 (21%)
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	181/486 (37%)
Sema1a	NP_001260265.1	PSI	545..>579	CDD:214655	12/36 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	317	1.000	Domainoid score	I1262
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	370	1.000	Inparanoid score	I2107
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000892
OrthoInspector	1	1.000	-	-		mtm8703
orthoMCL	1	0.900	-	-		OOG6_101616
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X415
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.820