DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema6a and Sema1a

DIOPT Version :9

Sequence 1:	XP_006525789.1	Gene:	Sema6a / 20358	MGIID:	1203727	Length:	1048	Species:	Mus musculus
Sequence 2:	NP_001260265.1	Gene:	Sema1a / 34192	FlyBaseID:	FBgn0011259	Length:	1131	Species:	Drosophila melanogaster

Alignment Length:	1141	Identity:	294/1141 - (25%)
Similarity:	452/1141 - (39%)	Gaps:	381/1141 - (33%)

- Green bases have known domain annotations that are detailed below.

Mouse    28 SISHGNYTKQYPVFVGHKPGRNTTQRHRLD-------IQMIMIM--------------------- 64
            |.|:.||.|.:.:.:.....:.|..:|:|.       :|:.:::
  Fly    13 SASNSNYNKGHKMHLKSATAKATIMKHKLSKFYGYGWMQVFLLLTVLVIGNQSAWQENIRPKLYV 77

Mouse    65 --------------------------NRTLYVAARDHIYTVDIDTSHTEEIYCSKKLTWKSRQAD 103
                                      ..:|.:.||:.::.:.|     .::...::|.|.|.:.|
  Fly    78 ELGPEDVLKFVGNESVVDHFKLVTKDGNSLLIGARNTVFNLSI-----HDLVEQQRLVWTSPEDD 137

Mouse   104 VDTCRMKGKHKDECHNFIKVLLKKNDDTLFVCGTNAFNPSCRNYRV-DTLETFGDEFSGMARCPY 167
            ...|.:|||.::.|.|:|::::..:...|||||||:|.|.|..|.: |:..|.....:|.|.|||
  Fly   138 TKMCLVKGKDEEACQNYIRIMVVPSPGRLFVCGTNSFRPMCNTYIISDSNYTLEATKNGQAVCPY 202

Mouse   168 DAKHANIALFADGKLYSATVTDFLAIDAVIYRSLGDSPTLRTVKHDSKWLKEPYFVQAVDYGDYI 232
            |.:|.:.::.||.:|||.||.||...|.:|||.     .|:|.::||..|..|.||.:...||::
  Fly   203 DPRHNSTSVLADNELYSGTVADFSGSDPIIYRE-----PLQTEQYDSLSLNAPNFVSSFTQGDFV 262

Mouse   233 YFFFREIAVEYNTMGKVVFPRVAQVCKNDMGGSQRVLEKQWTSFLKARLNCSVPGDSHFYFNILQ 297
            ||||||.|||:...||.::.|||:|||.|.||..| ...:||||||:|||||:|||..||||.:|
  Fly   263 YFFFRETAVEFINCGKAIYSRVARVCKWDKGGPHR-FRNRWTSFLKSRLNCSIPGDYPFYFNEIQ 326

Mouse   298 AVTDVIRINGR------DVVLATFSTPYNSIPGSAVCAYDMLDIANVFTGRFKEQKSPDSTWTPV 356
            :.:::  :.|:      .::...|:||.||||||||||:.:.|||:.|.|:||||...:|.|.||
  Fly   327 SASNL--VEGQYGSMSSKLIYGVFNTPSNSIPGSAVCAFALQDIADTFEGQFKEQTGINSNWLPV 389

Mouse   357 PDERVPKPRPGCCAGSSSLEKYATSNEFPDDTLNFIKTHPLMDEAVPSIINRPWFLRTMVRYRLT 421
            .:.:||.||||.|        :..|...||.||||||||.||||.||:..::|..:||...||.|
  Fly   390 NNAKVPDPRPGSC--------HNDSRALPDPTLNFIKTHSLMDENVPAFFSQPILVRTSTIYRFT 446

Mouse   422 KIAVD----NAAGPYQNHTVVFLGSEKGIILKFL-ARIGSSGFLNGSLFLEEMNVY--------- 472
            :||||    ...|  :.:.|:|:|::.|.|:|.: |....|.....|:.:||::|.
  Fly   447 QIAVDAQIKTPGG--KTYDVIFVGTDHGKIIKSVNAESADSADKVTSVVIEEIDVLTKSEPIRNL 509

Mouse   473 ---------NPEKCSYDGVEDKRIMGMQLDRASGSLYVAFSTCVIKVPLGRC--ERHGKCKKTCI 526
                     .|:..|||               .|.|.:...:.|:.:.|.||  ::...|.: |:
  Fly   510 EIVRTMQYDQPKDGSYD---------------DGKLIIVTDSQVVAIQLHRCHNDKITSCSE-CV 558

Mouse   527 ASRDPYCGWVRESGSC-AHLSP--LSRLTFEQDIERGNTDGLGDCHNSFVALNDISTPLPDYEMS 588
            |.:||||.|.:.:|.| :|.:|  |....|.|::..|.
  Fly   559 ALQDPYCAWDKIAGKCRSHGAPRWLEENYFYQNVATGQ--------------------------- 596

Mouse   589 FNRVYGHASSLYPSTTTSDSASRDGYESRGGMLDWNDLLEAPGSTDPLGAVSSHNHQDKKGVIRE 653
                  ||:.  ||...:...:..| |.:|...|. |||::             ..|.|...|.:
  Fly   597 ------HAAC--PSGKINSKDANAG-EQKGFRNDM-DLLDS-------------RRQSKDQEIID 638

Mouse   654 SYLKS-----------NDQLVPVTLLAIAVILAFVMGAVFSGIIVYCVCDHRRKDVAVVQRKEKE 707
            :..|:           |.|....||     ::|.:.|::||.::.:
  Fly   639 NIDKNFEGPQISADIINAQYTVETL-----VMAVLAGSIFSLLVGF------------------- 679

Mouse   708 LTHSRRGSMSSVTKLSGLF-GDTQSKDPKPEAILTPLMHNGKLATPSNTAKMLIKADQHHLDLTA 771
                          .:|.| |....||....
  Fly   680 --------------FTGYFCGRRCHKDEDDN---------------------------------- 696

Mouse   772 LPTPESTPTLQQKRKPNRGSREWERNQNIINACTKDMPPMGSPVIPTDLPLRASPSHIPSV---- 832
            ||.|::.            ...:|:.||:.:             .|:...::..|..:|.|
  Fly   697 LPYPDTE------------YEYFEQRQNVNS-------------FPSSCRIQQEPKLLPQVEEVT 736

Mouse   833 ----VVLPITQQGYQHEYVDQPKMSEVVAQMALEDQAATLEYKTIKEHLSSKSPNHGVNLVENLD 893
                |:||            ||....                   |.|    ||.:.:.
  Fly   737 YAEPVLLP------------QPPPPN-------------------KMH----SPKNTLR------ 760

Mouse   894 SLPPKVPQREASLGPPGTSLSQ---TGLSKRLEMQHSSSYGLEYKRSYPTNSLTRSHQ------- 948
                |.|..:...||...:|.|   .|.:.:...:...::|           ..||||
  Fly   761 ----KPPMHQMHQGPNSETLFQFQPDGYNTQQSYRGRDNFG-----------TLRSHQVMGDNYR 810

Mouse   949 -------TTTLKR--NNTNSSNSSHLSRNQSFGRGDNPPPAPQRVDSIQVHSSQPSGQAVTVSRQ 1004
                   |.::|:  ||||       :||:|.||....||   |...:..|.|....|....|:|
  Fly   811 RGDGFSTTRSVKKAVNNTN-------TRNRSLGRARRQPP---RHGIVTQHRSNSPQQQQQQSQQ 865

Mouse  1005 PSLNAYNSLTRSGLKRTPSLKPDVPPKPSFAPLSTS 1040
            |..::.:|...|....:|: .|...|.|..:|.:.|
  Fly   866 PHSSSGSSPVMSNSSSSPA-PPSSSPSPQESPKNCS 900

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema6a	XP_006525789.1	Sema_6A	48..513	CDD:200527	183/548 (33%)
Sema6a	XP_006525789.1	PSI	514..>546	CDD:366642	13/34 (38%)
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	180/492 (37%)
Sema1a	NP_001260265.1	PSI	545..>579	CDD:214655	13/34 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	317	1.000	Domainoid score	I1262
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	370	1.000	Inparanoid score	I2107
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000892
OrthoInspector	1	1.000	-	-		mtm8703
orthoMCL	1	0.900	-	-		OOG6_101616
Panther	1	1.100	-	-	LDO	PTHR11036
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4157
SonicParanoid	1	1.000	-	-		X415
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.850