DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema5b and Sema2a

DIOPT Version :9

Sequence 1:	XP_006521932.1	Gene:	Sema5b / 20357	MGIID:	107555	Length:	1122	Species:	Mus musculus
Sequence 2:	NP_477507.1	Gene:	Sema2a / 36846	FlyBaseID:	FBgn0011260	Length:	724	Species:	Drosophila melanogaster

Alignment Length:	744	Identity:	237/744 - (31%)
Similarity:	351/744 - (47%)	Gaps:	144/744 - (19%)

- Green bases have known domain annotations that are detailed below.

Mouse     7 LALSLLLSSLTLLVSHLSSSQDIASESSS-----EQQMCTRREHPIVAFEDLKPWVFNFTY---- 62
            |.||.||:.|.||.|  |.|:..|...::     |:..||..:..            |..|
  Fly     4 LQLSPLLALLLLLCS--SVSETAADYENTWNFYYERPCCTGNDQG------------NNNYGKHG 54

Mouse    63 -PGVRDFS-------QLALDPSRNQLIVGARNYLFRLSLANVSLLQAT-EWASSEDTRR---SCQ 115
             ..||:|:       ...::..|:.|.|||.:.:||::|.|:|..... :..:.|.||.   ||.
  Fly    55 ADHVREFNCGKLYYRTFHMNEDRDTLYVGAMDRVFRVNLQNISSSNCNRDVINLEPTRDDVVSCV 119

Mouse   116 SKGKTE-EECQNYVRVL--IVSGRKVFMCGTNAFSP--VCSSRQVGNLSRTIEKIN---GVARCP 172
            ||||:: .:|:|:|||:  :..|.::::|||||.:|  ......:.:|.|:...|.   |:|:||
  Fly   120 SKGKSQIFDCKNHVRVIQSMDQGDRLYVCGTNAHNPKDYVIYANLTHLPRSEYVIGVGLGIAKCP 184

Mouse   173 YDPRHNSTAVISSQGE------LYAATVIDFSGRDPAIYRS---LGSGPPL-----RTAQYNSKW 223
            |||..||||:....|.      ||:.|..:|:..|..|:|:   ..|...|     ||.:|:|||
  Fly   185 YDPLDNSTAIYVENGNPGGLPGLYSGTNAEFTKADTVIFRTDLYNTSAKRLEYKFKRTLKYDSKW 249

Mouse   224 LNEPNFVAAFDIGLFAYFFLRENAVEH-DCGRTVYSRVARVCKNDVGGRFLLEDTWTTFMKARLN 287
            |::||||.:||||.:.|||.||.|||: :||:.||||:|||||.||||:.||...|.|::|||||
  Fly   250 LDKPNFVGSFDIGEYVYFFFRETAVEYINCGKAVYSRIARVCKKDVGGKNLLAHNWATYLKARLN 314

Mouse   288 CSRPGEVPFYYNELQSAFHLP-EQDLIYGVFTTNVNSIAASAVCAFNLSAISKAFNGPFRYQENP 351
            ||..||.|||:||:||.:.|| ::...:..|||:.|.:..||||:|:::.|..||||.|:.|.:.
  Fly   315 CSISGEFPFYFNEIQSVYQLPSDKSRFFATFTTSTNGLIGSAVCSFHINEIQAAFNGKFKEQSSS 379

Mouse   352 RAAWLPIANP-IPNFQCGTLPETGPNENLTERSLQDAQRLFLMSEAVQPVTPEPCVTQDSVRFSH 415
            .:||||:.|. :|..:.||.  .....||.:..|...:...||.:||......|...:..:.|:.
  Fly   380 NSAWLPVLNSRVPEPRPGTC--VNDTSNLPDTVLNFIRSHPLMDKAVNHEHNNPVYYKRDLVFTK 442

Mouse   416 LVVDLVQAKDTL---YHVLYIGTESGTILKALSTASRSLRGCYLEELHVLPPGRLEPLRSLRILH 477
            ||||.::. |.|   |.|.|:||..|.|.|.:...........|.::..:.|.  |.::.:.|..
  Fly   443 LVVDKIRI-DILNQEYIVYYVGTNLGRIYKIVQYYRNGESLSKLLDIFEVAPN--EAIQVMEISQ 504

Mouse   478 SARALFVGLSDRVLRVPLERCS-AYHSQGACLGARDPYCGWDGKRQLC-----STLEDSSNMSLW 536
            :.::|::|...|:.::.|..|: .|.:...|:  ||||||||.:...|     ..|:|.:|.:..
  Fly   505 TRKSLYIGTDHRIKQIDLAMCNRRYDNCFRCV--RDPYCGWDKEANTCRPYELDLLQDVANETSD 567

Mouse   537 IQNITTCPVRNVTRDG-----GFGPWSP-----------------------WKPCEHLDGDNSGS 573
            |.:.:....:.|...|     |.....|                       :.|.::::....|.
  Fly   568 ICDSSVLKKKIVVTYGQSVHLGCFVKIPEVLKNEQVTWYHHSKDKGRYEIRYSPTKYIETTERGL 632

Mouse   574 CLCRARSCDSPRPRC---GGLECLGPSIHIA---------NCSRN-----GAW--------TAWS 613
            .:......|..|..|   |.|.|   |.:|.         |.|.:     ..|        ||..
  Fly   633 VVVSVNEADGGRYDCHLGGSLLC---SYNITVDAHRCTPPNKSNDYQKIYSDWCHEFEKYKTAMK 694

Mouse   614 SW----AQCSTSCGIGFQVRQRSCSNPAP 638
            ||    |||||        ||...||..|
  Fly   695 SWEKKQAQCST--------RQNFSSNQHP 715

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema5b	XP_006521932.1	Sema	60..496	CDD:387663	173/479 (36%)
		PSI	497..544	CDD:366642	16/52 (31%)
		TSP1	609..662	CDD:214559	15/42 (36%)
		TSP1	667..742	CDD:214559
		TSP1	827..879	CDD:214559
		TSP1	884..936	CDD:214559
		TSP_1	940..981	CDD:387593
Sema2a	NP_477507.1	Sema_2A	66..523	CDD:200499	169/461 (37%)
Sema2a	NP_477507.1	Ig_Semaphorin_C	573..664	CDD:143180	14/93 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9633
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840