DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema5a and Sema1b

DIOPT Version :9

Sequence 1:	NP_033180.2	Gene:	Sema5a / 20356	MGIID:	107556	Length:	1074	Species:	Mus musculus
Sequence 2:	NP_001163178.1	Gene:	Sema1b / 37007	FlyBaseID:	FBgn0016059	Length:	770	Species:	Drosophila melanogaster

Alignment Length:	503	Identity:	180/503 - (35%)
Similarity:	255/503 - (50%)	Gaps:	52/503 - (10%)

- Green bases have known domain annotations that are detailed below.

Mouse    54 NAVDFSRLTFDPGQKELVVGARNYLFRLELEDLSLIQAVEWECDEATKKACYSKGKSKEECQNYI 118
            |:.|:.:: .|...:.::|||::.::.:.|..|..|..:||...:|.::.|..|||.:.:|.||:
  Fly    56 NSTDYFKI-LDHNDEFVLVGAKDVIYNVSLNGLKEIARLEWHSTDADRELCALKGKHEWDCHNYL 119

Mouse   119 RV--LLVGGDRLFTCGTNAFTPVCTIRSLSNLT---------------EIHDQISGMARCPYSPQ 166
            ||  |...|:.|. ||||::.|.|...:...::               |:...:.....|||||.
  Fly   120 RVYALRPNGEVLL-CGTNSYKPRCRHYTPVEVSSEEAGSAGHAHAMRYEVSRDVEAQGLCPYSPA 183

Mouse   167 HNSTALLTASGELYAATAMDFPGRDPAIYRSLGTLPPLRTAQYNSKWLNEPNFVSSYDIGNFTYF 231
            ||||... |.|.||:||..||.|.||.|||.     .|||.||:.|.||:|:||.:.:...:..|
  Fly   184 HNSTYAF-ADGHLYSATVADFSGGDPLIYRE-----NLRTEQYDLKQLNQPDFVGAIERNGYVLF 242

Mouse   232 FFRENAVE-HDCGKTVFSRAARVCKNDIGGRFLLEDTWTTFMKARLNCSRPGEVPFYYNELQGTF 295
            ||||.::| .:.||.|:||.|||||||.||.:....:||:|:|||||||.|||.|||::|:|...
  Fly   243 FFRELSMEVMNFGKAVYSRVARVCKNDRGGPYSHGKSWTSFLKARLNCSVPGEFPFYFDEIQAIS 307

Mouse   296 FLPE---LDLIYGIFTTNVNSIAASAVCVFNLSAISQAFNGPFKYQENSRSAWLP-----YPNPN 352
            .:.|   ..|||.:|||:||:|..||||.||:..|..||:|.||.|::|:|.|||     .|.|.
  Fly   308 PIVESGSKSLIYAVFTTSVNAIPGSAVCAFNVDDILAAFDGEFKSQKDSQSHWLPVEREQVPKPR 372

Mouse   353 PNFQCGTMDQGLYVNLTERNLQDAQKFILMHEVVQPVTTVPSFMEDNSRFSHLAVDVVQGRETL- 416
            |. ||....:    .||...:...:...||.|.|..|...|...:.|......|:.|....::|
  Fly   373 PG-QCVEDSR----TLTSIAVNFIKNHPLMEEAVPAVHGRPLLTKVNLHHRLTAIAVHPQVKSLS 432

Mouse   417 ---VHIIYLATDYGTIKKVRAPLSQSSGS-------CLLEEIELFPERRSEPIRSLQILHSQSVL 471
               ..:||..||.|.:.|....||....|       .::.|:::.|  ...|||.|.|..|::.|
  Fly   433 GAYYDVIYSGTDDGKVTKFINILSTHPNSTVDRLKTVVISEMQVLP--LGTPIRELVISTSKNSL 495

Mouse   472 FVGLQEHVAKIPLKRCHFHQTRSACIGAQDPYCGWDAVMKKCTSLEES 519
            .|.....:..:||..|........|:..|||.|.||....:|.:|..|
  Fly   496 VVVSDGSLVSVPLHHCSHIVDCLGCLSLQDPICAWDLQTHECKNLATS 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema5a	NP_033180.2	Sema_5A	50..485	CDD:200524	168/467 (36%)
		PSI	486..533	CDD:396154	11/34 (32%)
		TSP1	544..595	CDD:214559
		TSP1	598..651	CDD:214559
		TSP1	656..702	CDD:214559
		TSP1	787..839	CDD:214559
		TSP1	853..896	CDD:214559
		TSP1	899..940	CDD:214559
Sema1b	NP_001163178.1	Sema_1A	55..511	CDD:200498	169/469 (36%)
Sema1b	NP_001163178.1	PSI	510..>537	CDD:214655	8/26 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810